Title: Research Associate/Senior Research Associate
Department: Molecular Biology and Microbiology
This NIH funded position is to study HIV-1 interaction with the host cell, with a focus on discovery and characterization of new restriction factors that inhibit early steps in HIV-1 infection. Discovery tools include a variety of high throughput approaches including a combination of biochemical and proteomic techniques, transcriptome analyzes etc. Target validation tools include innovative biochemical, cell biology and virologic methods to interrogate the role of candidate restriction factors on HIV-1 replication. The RA/SRA will work in context of team engaged in two national collaborations.
1. Perform independent original studies in the area of molecular, biochemical and cell-based characterization of virus-host cell interaction using virologic and/or molecular/biochemical approaches. Maintain meticulous records of experiments. (75%)
2. Collaborate with and/or supervise other group members in experimental design and data analysis, coordinate external collaborations, as required. (10%)
3. Write research papers and reviews. Present research results at national and international conferences. (10%)
No supervisory responsibilities
Experience: Minimum 3-5 (RA – SRA) years of experience in virology/HIV research; multiple publications
Education/Licensing: PhD in Molecular Virology, Biochemistry or Genetics.
1. Working knowledge of molecular cloning, RNA, DNA, protein techniques, cell culture,
2. Virus production, gene transfer approaches using transfections, retroviral transduction.
3. Analytical techniques including flow cytometry, real time PCR, virus replication assays.
The employee will be working in a laboratory in the Department of Molecular Biology and Microbiology. Experiments using retroviral vectors and viruses will be carried out under BSL2/BSL2+ conditions. There are no unusual hazards; possible exposure to the usual hazards in the form of general chemicals, bloodborne pathogens, paraformaldehyde, phenol, chloroform, methanol, ethidium bromide, ultraviolet light, sonication, and potentially, to radioisotopes. Required personal protective equipment includes a standard lab coat, gloves and safety glasses when appropriate. The employee will need to be able to lift up to 25 lbs, bend/stoop, crouch, push, pull and reach above shoulders. The employee will use repetitive motion, including the use of a keyboard and computer mouse while performing job duties
Send inquiries containing a cover letter, CV with list of publications and contact information for three references to firstname.lastname@example.org. Review of applications will begin immediately and continue until the position is filled.
In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.
Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.