The Department of Molecular Biology and Microbiology at Case Western Reserve University School of Medicine seeks a highly motivated Research Scientist to conduct research in the laboratory of Dr. Jonathan Karn, Reinberger Professor of Molecular Biology and Microbiology; Chair, Department of Molecular Biology and Microbiology; Director, CWRU/UH Center for AIDS Research.
The responsibilities of this position include planning and executing projects on the epigenetic regulation of HIV transcription in T cells and microglial cells. There are a variety of ongoing projects including studies of lncRNA, nuclear receptors, impact of drugs of abuse and use of CRISPRs to eradicate HIV. The Research Scientist will perform data analysis utilizing statistical and bioinformatics tools, prepare manuscripts and contribute preliminary data, background and significance and experimental design for grant proposals, and write, submit and serve as Principal Investigator or key personnel on grants and manuscripts. In addition, this project will require advanced experimental skills in molecular virology including next generation sequencing and the use of advanced flow cytometry. The successful applicant will develop and present workshops on research methods and scientific findings, and will participate in the CWRU/UH Center for AIDS Research.
Key responsibilities will include (1) design, carry out and troubleshoot experiments using molecular virological biological, biochemical, genetic, and advanced cell and molecular imaging techniques; (2) develop new protocols and techniques as needed, and (3) collect and analyze data, amend research direction as dictated by the results and developments in the field. The Research Scientist may supervise and collaborate with other group members including postdocs, research associates, and graduate students in conducting sample preparation, experimental design and data analysis of a variety of projects.
The ideal candidate will have (1) advanced molecular virological biological, biochemical, genetic, and cell and molecular imaging techniques, including the use of ChIP and EDITS assays; (2) strong expertise in the biochemistry of transcription, molecular virology and/or gene expression in mammalian cells; (3) experience in the biochemistry of transcription, molecular virology and/or gene expression in mammalian cells; (4) advanced experimental skills in biochemistry and molecular biology related to DNA cloning, quantitative PCR, next generation sequencing, and detection of gene expression, and (5) knowledge of next generation sequencing and advanced flow cytometry. Experience using single cell analysis methods including flow cytometry and single cell sequencing is preferred.
The applicant must have a PhD in Molecular Virology, Biochemistry or Genetics, more than 9 years of experience in Cell and Molecular Virology of HIV, with an excellent record of multiple publications.
Please send inquiries containing a cover letter, CV with a list of publications, and contact information of 3 references to Brinn Omabegho re: Research Scientist Position via email: 33940RS@case.edu . Review of applications will begin immediately and continue until the position is filled.
In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.
Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.