Date: October 2021
Title: Research Scientist
Supervisor Name and Title: Stephen J. Lewis, Professor
The Research Scientist will work closely and in collaboration with Dr. Stephen Lewis to plan, implement, and lead research work that focuses on understanding the mechanisms by which opioids depress breathing and the mechanisms by which a novel series of thiol ester drugs reverse the negative effects of opioids on ventilatory parameters without affecting analgesia. The laboratory employs whole animal, in vitro electrophysiological techniques, and molecular biological approaches in their investigations. The technology includes whole-body and two-chamber head-out plethysmography, implantable telemetry devices for monitoring arterial blood pressure, Doppler flow probes for monitoring vascular blood flows and resistances, implantable electrodes to record and/or stimulate peripheral autonomic nerves, implantable electrodes to record diaphragmatic and genioglossus muscle electromyograms and an array of microelectrode recording techniques to monitor single cell activity. . The Research Scientist will manage laboratory personnel, providing scientific oversight, guidance, and mentorship to other research personnel in the lab. The Research Scientist will be expected to independently write and submit grants and serve as the PI on grant-funded projects.
Applications should be emailed to Dr. Stephen J. Lewis Ph.D. firstname.lastname@example.org .
- Perform advanced research into signaling pathways that pertain to central and peripheral cardiorespiratory control systems using techniques such as in vivo surgical preparations requiring recording of peripheral nerve activities and hemodynamic monitoring; whole-cell patch clamp electrophysiology; whole-body plethysmography, and molecular biological approaches. (20%)
- Perform data collection and applying advanced statistical analyses including repeated measures ANOVA with multiple comparison tests using statistical packages such as SigmaPlot. (20%)
- Co-Author manuscripts and review articles for publication in peer-reviewed journals. Prepare abstracts for scientific conferences. Attend and present findings at national and international scientific meetings, as well as department seminars. (20%)
- Develop their own research directions, design experiments, manage issues of scientific method (including controls, reproducibility, sample size estimate valuation, trends, troubleshooting and refining techniques into Standard Operating Procedures for lab and lab staff. (10%)
- Coordinate experiments performed by other lab members, ensuring adequate resources, assisting with experimental design and analysis. Oversee progress of research projects and provide regular progress reports to the PI, and provide input and recommendation to the principal investigator regarding significant developments in research projects. Ensure the PI is informed about the results of lab members, and ensure the PIs experimental strategy is explored by lab members and through independent experiments by the Research Scientist. (10%)
- Supervise research assistants and technicians. Supervise the research and technical work performed by other lab members ensuring proper lab procedures are followed, and their safety, and ensuring adequate resources are provided for lab work. Train junior and other senior laboratory personnel. Ensure careful documentation for all lab staff. Provide overall management of more than five ongoing projects in the laboratory. (10%)
- Independently write and apply for grants as Principal Investigator. Submit subsequent grant applications as needed to maintain independent research funding. (5%)
- Operate laboratory equipment. Assist other lab members with general lab maintenance and help oversee and maintain inventory of scientific reagents. Manage inventory and stock of mice, rats and other animals in conjunction with the Animal Resource Center. (5%)
- Perform other duties as assigned (%).
Department: Frequent contact with PI and lab members, may work with other faculty for collaboration of research projects, contact with administrative staff as needed
University: Regular/Occasional contact with other labs for collaboration, Regular/Occasional contact with the Animal Resource Center, Contact with other departments as needed
External: Supply vendors, other institutions, funding agencies, etc. as needed
Students: Undergraduate and graduate student employees working in the lab
SUPERVISORY RESPONSIBILITY: Train and oversee rotation of students and lab personnel. Provide essential technical advice at bench and take part in discussions with them. The holder of the position will have supervisory responsibility including recommending reward or discipline of the individuals they will have responsibility for directing, including a research team consisting of graduate students and a research assistant.
Experience: Minimum of 5 years of related postdoctoral experience in the fields of electrophysiology of peripheral and central neurons and whole-body plethysmography in rats and mice. Demonstrated experience in neurophysiology and neuropharmacology with background in advanced electrophysiological and molecular biology required. Less experience and demonstrated expertise in a particular field of study will be considered. Must demonstrate a proven track record in publications in the field of cardiorespiratory research and contributions to successful grant applications
Education/Licensing: PhD, MD or other terminal degree in in Physiology/Biophysics or Neuropharmacology.
REQUIRED KNOWLEDGE, SKILLS and ABILITIES
- Ability to effectively perform and train others in S-nitrosothiol signaling mechanisms.
- Demonstrated (published) expertise in whole-body plethysmography.
- Demonstrated (published) expertise in the dissection of nuclei from the brains of rats and mice.
- Excellent oral and written communication skills and interpersonal skills; must demonstrate the ability to effectively and professionally communicate and work with various individuals within and external to the University.
- Strong organization skills; ability to multi-task, prioritize and meet deadlines. Must demonstrate attention to detail and accuracy, time management skills, and follow-through. Must be able to work under pressure and conform to shifting priorities, demands and timeline.
- Effective management skills; ability to lead, train, work with, and elicit cooperation from team members and staff.
- Ability to work effectively independently and collaboratively within a team. Must be highly motivated, responsible, dependable and a self-starter.
- Effective problem-solving skills; must demonstrate innovation and creativity, excellent analytical skills, sound judgment and good decision-making.
- Excellent computer skills, including database management, constructing graphs and diagrams, and advanced statistical analyses.
- Must demonstrate compliance with CWRU animal research and care (ARC) policies and procedures and compliance to regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines and other applicable regulatory guidelines.
- Must demonstrate compassion for animals within CWRU facilities and dedication to the Animal Resource Center’s mission. Must handle animals with care and respect at all times.
- Must be able and willing to maintain a high standard of personal cleanliness and utilize protective gear to protect the health the animals.
General laboratory environment. Will require working at the bench in a laboratory with mice and other animal models in the laboratory and in the animal facility. When needed, working outside standard working days or hours as required by the needs of a given experiment. May have exposure to chemical hazards. Will be working with animals in a research setting.
Case's animal facilities are accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC) and is managed according to the "Guide for the Care and Use of Laboratory Animals” appropriate Federal Animal Welfare Regulations, and the Public Health Service “Policy on the Humane Care and Use of Laboratory Animals." This position, and all animal research personnel, are subject to internal compliance to SOM Animal Resource Center Standard Operating Procedures and to compliance regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines, the State of Ohio Veterinary Practice Act, Federal Drug Enforcement Administration regulatory guidelines, US Food and Drug Administration Center for Veterinary Medicine regulations and other applicable regulatory guidelines.
In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.