Senior Research Associate - Center for Global Health and Diseases

Date: January 9, 2020

Title: Senior Research Associate/Mass Spectrometry Scientist

Department: Center for Global Health and Diseases, Department of Pathology

School: Medicine

Location: BRB

Supervisor Name and Title: Adam Burgener, Ph.D., Professor of Pathology

POSITION OBJECTIVE

The person who holds this position will work independently as a Senior Research Associate/Mass Spectrometry Scientist in the Burgener research lab. This will include daily management and operation of the latest Thermo Orbitrap systems, including an Eclipse Tribrid, Q-Exactive HF-X, and related mass spetrometry instrumentation.

This also includes operation of advanced liquid chromatography instrumentation. The Mass Spectrometry Scientist, in coordination with the Bioinformatics Unit, will oversee mass spectrometry data processing and bioinformatic pipelines related to proteomics and metabolomics. This will also include managing QC of instrumentation, troubleshooting instrument issues, and servicing of instruments with Thermo engineers, in coordination with staff and scientists at the Center for Proteomics and Bioinformatics. This person will develop methodologies and analytical pipelines for metabolomic analysis for clinical studies, as well as metaproteomics for microbiome studies. The Mass Spectrometry Scientist will provide guidance to technicians, students, and other staff in the lab for mass spectrometry-related projects, and ensure that study milestones are completed according to agreed standards and timelines. The Mass Spectrometry Scientist will have opportunity to present selected data at international meetings with collaborators or conferences. Other responsibilities of this position will include, in coordination with the Bioinformatics Unit, development of R-based tools for management of mass spectrometry data, the generation of reports to support the aims of the CIHR and NIH awards, carry out smaller components of collaborative research projects, assist in the publication of results from other lab members and the development of new hypotheses for grant applications.

 

A strong candidate has been identified.

 

ESSENTIAL FUNCTIONS

l . Manage the mass spectrometry unit (75%)

Carries out technical duties related to mass spectrometry and liquid chromatography, as required by research projects and lab priorities. Supervise all phases of analysis from sample preparation, mass spectrometry analysis, data processing and quality control through final analytical results and reporting

Assists technical support staff and graduate students with the planning of mass spectrometry-related research projects. Co-ordinates research projects with external clinical trials groups and research labs that relate to assigned research projects. Work collaboratively with all functional areas to facilitate teamwork and communication that will support the success of the research studies.

Develop and implement existing methodologies for shotgun metabolomic and proteomic analysis.

Assist in the implementation and development of bioinformatic tools and workflows to process, analyze and integrate mass spectrometry data

 

Develop and implement training for staff related to metabolomic and proteomic experiments

Co-develop research objectives and direction in metabolomics and proteomics with principal investigator.

Maintain and organize data repository for the lab in coordination with Bioinformatics Unit. Assist and support Faculty scientists in their research programs for the exploration of proteomics and metabolomics to study host immunity and disease

  1. Prepare data analysis reports, assist in writing of research manuscripts, and grant applications. (15%)
  2. Lead analysis on selected collaborative research projects, generate data outputs and interpret data for reports and publications, and coordinate with team members to deliver data analysis on assigned projects. (10%)

NONESSENTIAL FUNCTIONS

1. Perform other duties as assigned.

CONTACTS

Department: Daily contact with PI, Frequent contact with Department Administration

University: Frequent contact with other CWRU collaborating Departments including other basic science departments, and ITS

External: Frequent contact with Thermo vendors and other collaborating institutions

Staff/Students: Daily contact with staff and students

SUPERVISORY RESPONSIBILITY

2 junior technical staff (Tech 1-2).

QUALIFICATIONS

Experience: Minimum of 5 years’ experience in mass spectrometry, including instrument operation and proteomic/metabolomic data analysis. Experience in human clinical proteomics, metabolomics, and microbiome studies.

Education/Licensing: Ph.D. required in Chemistry, Biology, Physics, or related field.

REQUIRED KNOWLEDGE, SKILLS and ABILITIES

  1. Detailed knowledge of hybrid orbitrap instrumentation, including operation, servicing, and interpretation of mass spectrometry data.
  2. Demonstrated expertise in Proteomics and Metabolomics
  3. Demonstrated knowledge of application of mass spectrometry to study human disease.
  4. Demonstrated knowledge of liquid chromatography and related chemistry.
  5. Professional and effective oral and written communication skills; and good interpersonal skills with the ability to work and communicate with various individuals within and external to the University. Must be able to clearly relay information to the PI and other researchers and prepare written documents for grant submissions, including experience writing manuscripts, publications, etc.
  6. Strong organization skills; ability to multi-task, prioritize and meet deadlines. Must demonstrate attention to detail and accuracy, time management skills, and follow-through.
  7. Effective management skills; ability to lead, train, work with, and elicit cooperation from team members and staff.
  8. Ability to work effectively independently and collaboratively within a team. Must be highly motivated, responsible, dependable and a self-starter. Must demonstrate a strong desire to learn and to advance research.
  9. Effective problem-solving skills; must demonstrate excellent analytical skills, sound judgment and good decision-making.
  10. Must demonstrate flexibility and ability to work under pressure; must be able and willing to conform to shifting priorities, demands and timeline.
  11. Willingness to follow protocols and provide suggestions to the Pl.
  12. Ability to operate laboratory equipment.
  13. Good computer skills; must demonstrate proficiency in Microsoft Office, data management, knowledge of programming languages, including R, specifically in analysis of proteomic and metabolomic data.

WORKING CONDITIONS

Employee will be working in a standard research lab environment, including but not limited to exposure to infectious agents, blood-borne pathogens, human serum/plasma and human blood cells, repetitive motion, chemicals, UV light, fumes, dust, others. The employee will need to be able to lift up to 20 lbs. The employee will perform DOT shipping/receiving of infectious materials.

May need to work nights and weekends if necessary to complete data processing. Will need to complete all necessary DOES safety trainings.

DIVERSITY STATEMENT

In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.

 

HOW TO APPLY

Qualified applicants should send their CV to adam.burgener@case.edu with a copy to mll6@case.edu.