New position available in the translational lab of Dr. Afshin Dowlati, M.D., focused on small cell lung cancer (SCLC) research. This new project centers on the role of epigenetics and alternative splicing in determining the SCLC phenotype and chemo-response. The goal is to identify genetic signatures which may stratify patients with the potential to predict tumor behavior and/or therapeutic responses. Both cell culture and PDX models of SCLC will be used in these investigations. Candidate should have hands-on experience with most cell and molecular biological procedures basic to tumor cell biology: cell culture, western blotting, cell proliferation, migration and apoptosis assays, RNA/DNA isolation, qPCR, luciferase assays, FACS, CHIPs, etc. Knowledge of bioinformatics and/or epigenetic techniques a must. Experience with xenograft and PDX models of tumor growth desired. Future directions may include opportunities to develop a SCLC GEMM. The research environment is outstanding and is based in the Case Comprehensive Cancer Center. The candidate is expected to secure independent funding within 3 years. Immediately prior to the candidate applying to their own independent grant the position will be promoted to a research scientist.
- Communicate/discuss experimental approach/plans with the principal investigator and program manager (10%)
- Independently carry out complex research assignments of a non-routine nature. Evaluate adequacy of techniques; develop and test new procedures and analyze data (70%)
- Help prepare grant and manuscript submissions (5%).
- May supervise rotating students and research assistants (5%).
- Willing to work with mice and perform tumor growth experiments (5%).
Expected to work after hours/weekends if required by experiments (5%).
Perform other duties as assigned.
Department: Routine contact with program manager (daily) and PI (twice per week).
University: Occasional contact with university collaborators and research cores (monthly).
External: Maintain and develop contacts with external collaborators (as needed).
Students: Contact with rotating graduate students (as needed).
May supervise rotating graduate students and research assistants.
Experience: 5+ years of post-doctoral experience required.
Education/Licensing: Ph.D. degree required.
- Candidate must be a self-motivated, critical thinker with a good work ethic and a collaborative demeanor.
- Has knowledge of commonly-used concepts, practices, and procedures within a research lab.
- Cell culture experience.
- Experience with bioinformatics and/or epigenetic methods.
- Must have excellent written and oral communication skills.
- Initially will be expected to contribute to manuscript and grant writing.
- Will be expected to apply for own funding within three years.
General laboratory environment. Must be willing to work with mice.
Interested candidates should email a resume/CV and a cover letter to Gary Wildey at firstname.lastname@example.org
Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.
In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.