Senior Research Associate - Genetics & Genome Sciences


Title: Senior Research Associate

Department: Genetics & Genome Sciences

School: Medicine

Location: BRB

Supervisor Name and Title: Christopher D McFarland, PhD, Assistant Professor


Please email your CV/Resume to



This position is a senior level position. The Sr. Research Associate will collaborate with faculty, department staff, post-doctoral fellows, students and technicians in the performance and analysis of complex and advanced research studies. The individual in this position will use computational biology, quantitative health statistics, mathematical and systems biology modeling, and molecular genetics as part of ongoing projects related to the study of human cancer from an evolutionary perspective. 


  1. Devise, design, and code new algorithms and evolutionary simulations of tumor progression and drug response. 25% 
  2. Use analytical mathematical approaches to understand fitness landscapes of tumor progression and their ability to be inferred from massive, publicly-available genomic screens in cancer. 15% 
  3. Serves as an advisor and provides mentorship to other researchers in the conduct and analysis of research studies. 10% 
  4. Manages and maintains a shared lab software base for the modeling of tumor progression and analysis of next generation sequencing data. 5% 
  5. Work with and guide others in the lab to develop mathematical models, process sequencing data, and perform statistical genomic analyses. 10% 
  6. Collaborate with PI in preparation of manuscripts. 10% 
  7. Carry out all computational biology techniques, including but not limited to model design, algorithm optimization, software management (code review, refactoring, deployment on high-performance computing clusters), statistical analysis of simulated and real data, and data visualization. 10% 
  8. Analyze all data and co-author research manuscripts with lab research teams. 5% 
  9. Conducts literature searches and generates date for the development of grant proposals. 5% 
  10. Help PI supervise graduate students. 5% 


NON-ESSENTIAL FUNCTIONS (Marginal or infrequent functions)

  1. Perform other duties as assigned. 
  2. The lab also performs DNA barcoding and multiplexed gene-editing techniques in mice, and so any experience analyzing mouse models of tumorigenesis is a plus. 


CONTACTS (indicate frequency (daily, weekly, etc.); position contacted; frequency; and purpose of contact)

Will meet weekly with Principal Investigator (schedule permitting) to plan and discuss research progress. 

Department: Daily contact with supervisor.

University: Occasional contact with other departments.

External: Limited or no contact with vendors to exchange information.

Students: Contact with student employees.



May supervise students and technicians



Experience: 5+ years of postdoctoral training required.

Education/Licensing: PhD in Physics or any quantitative scientific field of study.

Must have extensive experience in computational biology, bioinformatics, systems biology, and mathematical modeling. Must have multiple first author publications in peer reviewed journals.
Must have leadership experience. 



  1. Knowledge and understanding of commonly-used concepts, practices, and procedures within the field of systems biology. 
  2. Ability to code, develop and deploy mathematical models of tumor progression. 
  3. Demonstrated ability to statistically analyze next generation DNA sequencing and ‘omics’ datasets. 
  4. Excellent oral and written communication skills and interpersonal skills; must demonstrate the ability to effectively and professionally communicate and work with various individuals from a broad spectrum of disciplines, technical and educational backgrounds within the department, School and University, and with individuals outside the University. 
  5. Good/Strong organization skills; ability to multi-task, prioritize and meet deadlines. Must demonstrate attention to detail and accuracy, time management skills, and follow-through. 
  6. Effective management skills; ability to lead, train, work with, and elicit cooperation from team members and staff. 
  7. Ability to work effectively independently and collaboratively within a team. Must be highly motivated, responsible, dependable and a self-starter. 
  8. Ability to work with sensitive information and maintain confidentiality. 
  9. Effective problem-solving skills; must demonstrate excellent analytical skills, sound judgment and good decision-making. 
  1. Must demonstrate flexibility and ability to work under pressure; must be able and willing to work in a fast-paced, changing environment, and conform to shifting priorities, demands and timeline. 
  2. Willingness and ability to rely on and follow instructions and pre-established guidelines to perform the functions of the job. 
  3. Ability to operate laboratory equipment. 
  4. Must demonstrate willingness to learn new techniques, procedures, processes, and computer programs as needed. 


General laboratory environment: The lab is an open floor plan with abundant space. Ample desk space with computers are also provided. 



In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity.  Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.