Senior Research Associate, Medicine, Division of Pulmonary, Critical Care and Sleep Medicine

Title:

Senior Research Associate

Department:

Medicine, Division of Pulmonary, Critical Care and Sleep Medicine

School:

Medicine

Location:

Biomedical Research Building, Room 347

Supervisor Name and Title:

Rodney J. Folz, MD, PhD, Professor of Medicine

POSITION OBJECTIVE

Working both independently and within a research team, the senior research associate will carry out complex and high level research associated with furthering our understanding of mechanisms and pathways by which oxidative stress and redox active biomolecules regulate and/or control cardiopulmonary function both in healthy and diseased states. In addition, the senior research associate will be responsible for helping Dr. Folz securing additional funding on related topics.

ESSENTIAL FUNCTIONS

  1. Conduct and oversee laboratory research activities to examine oxidative stress and redox control mechanisms of cardiopulmonary function in both animal models and in human samples.        

  2. Perform ELISA measurements of sputum biomarkers; perform sputum cell counts and differential analyses. 

  3. Assess immunological responses to asthma and other disease states using a variety of methods including ELISA, immunofluorescence microscopy, real time PCR, and protein analyses techniques.  

  4. Consent human subjects and collect research samples from these subjects.

  5. Organize and analyze all data resulting from these studies

  6. Write and submit grants for independent funding, author and co-author research projects, present results at national meetings.

  7. Utilize new and innovative research techniques involving a high degree of skill and training.

  8. Anticipate, troubleshoot and correct potential difficulties in carrying out research projects.

  9. Read and stay up to date in current scientific reports concerning research topics related to the laboratory’s projects.

  10. Monitor the laboratory budget, consult with supervisor and administrator to ensure laboratory funds are well managed.

  11. Supervise post-doctoral and graduate students, as well as pulmonary fellows who rotate through the lab.

  12. Prepare and modify protocols for performance of human and animal research. Prepare reports for maintenance of these approvals.

  13. Instruct new lab personnel in the techniques and procedures necessary to carry out the research projects of the laboratory.

NONESSENTIAL FUNCTIONS

  1. Perform routine maintenance within the laboratory, including cleaning of equipment and lab ware, discarding biohazardous waste, and order supplies.

  2. Maintain laboratory certifications for general lab safety, biohazard handling, chemical safety, and handling of infectious pathogens.

  3. Assist in preparation and modification of protocols for performance of human and animal research (IRB and IACUC protocols), and in preparing periodic reports for maintenance of these approvals.

  4. Perform other duties as necessary.

CONTACTS

Department: Regular contact with Pulmonary Division chief (supervisor), other division personnel and laboratory staff; occasional interaction with department officials involved in protocol review and approval

University: Regular interaction with internal collaborators and other investigators, and moderate interactions with university officials involved in supervising laboratory safety, in budgets, purchasing, and subject reimbursement, and in approving protocols for human subjects and animal research

External: Moderate interaction with outside collaborators, and with suppliers and manufacturers of materials used in the laboratory

Students: Infrequent interactions with students other than those who may work in the laboratory.

SUPERVISORY RESPONSIBILITY

May supervise post-doctoral associates, graduate students and/or research assistants who work in the laboratory.

QUALIFICATIONS

Experience: 5 years of experience conducting independent research projects in cell biology, physiology, genetics or related topics.

Education/Licensing: MD and/or PhD in cell biology, physiology, genetics or related area required.

REQUIRED SKILLS

  1. Knowledge, understanding of and proficiency in commonly-used concepts, practices, and procedures within the fields of cell biology, physiology and human sample handling, including but not limited to mouse breeding, maintenance and experimentation, ELISA’s, use of adeno-viral vectors in mice as a gene-delivery system, lung analyses (morphometry, inflammation, fibrosis, apoptosis), RNA analysis and protein expression in lungs, RT-qPCR, taqman assays, immunohistochemistry, immunofluorescence, isolation, culturing and analysis of different types of primary alveolar cells, development of multiple assays for detection of protein post-translational modifications in vitro and in vivo, analysis of protein disulphide isomerase modification, enzymatic activity assays in cells, cigarette smoke exposure to animals. 

  2. Basic laboratory skills including, but not limited to, pipetting, centrifugation, aliquoting, preparation of media and culture plates, typical laboratory mathematic calculations

  3. Must be compliant with Animal Resource Center (ARC) policies and procedures and with regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines and other applicable regulatory guidelines for animal research.

  4. Must demonstrate familiarity with Institutional Review Board (IRB) policies and with principals and procedures involving human subjects and human samples used in research.

  5. Strong organization skills; ability to multi-task, prioritize and meet deadlines. Must demonstrate attention to detail and accuracy, time management skills, and follow-through.

  6. Strong interpersonal skills; ability to work and communicate with various individuals from a broad spectrum of disciplines, technical and educational backgrounds within the department, school and university, and with individuals outside the university.

  7. Ability to work effectively independently and collaboratively within a team. Must be highly motivated, responsible, and dependable.

  8. Effective problem-solving skills; must demonstrate excellent analytical skills, sound judgment and good decision-making.

  9. Good computer skills (database applications, graphics and presentations, internet)

  10. Must demonstrate willingness to learn new techniques, procedures, processes, and computer programs as needed in order to progress research projects

  11. Professional and effective verbal and written communication skills.

WORKING CONDITIONS

The position requires work in a basic science laboratory. It also requires work with human subjects and samples as well as with research animals. The position, therefore, requires annual retraining in handling of blood borne pathogens, protection of human subjects, and principles of performing animal research. This is an exempt position and hours are not limited to 40 hours/week. Travel to present research results at scientific meetings will be required.

Interested applicants, please send a copy of their CV and three professional references to Dr. Rodney Folz at rodney.folz@case.edu

In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity.  Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.

Case Western Reserve University provides reasonable accommodations to applicants with disabilities.  Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation.  Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.