Science Café Cleveland presents


"A Rational Approach to Finding a

Cure for Arthritis"



MAY 12, 2014





Dr. Charles Malemud

Arthritis Research Laboratory, Department of Medicine, Division of Rheumatic Diseases, CWRU, School of Medicine

and University Hospitals Case Medical Center




Rheumatoid arthritis (RA) is an autoimmune disease stemming from underlying genetic, socio-demographic and environmental factors, some of which are modifiable (e.g. smoking). The CDC estimates that RA ranges from 0.5% to 1.0% of the US population. In 2005, an estimated 1.5 million adults aged 18 or older were diagnosed with RA, down from 2.1 million in 1990. The characteristics of RA, which can be confirmed by radiographic analysis, are the destruction of articular cartilage and bone erosion that generally begins in the first year after the diagnosis of RA is confirmed. There is no known cure for RA. At the present time, RA is treated using a variety of first-line interventions such as non-steroidal anti-inflammatory drugs. Starting around 1998, the medical therapy of RA was revolutionized with the introduction of biologic drugsdrugs that target specific molecules intimately involved in the pathology of RA. Additional biologic drugs have since been developed following a rational approach to identifying and altering the activity of various elements involved in RA. Future drug development for RA is likely to require a more detailed understanding of the pathobiology involved in the genesis and progression of RA.







The Tasting Room at Great Lakes Brewing Company

2701 Carroll Avenue

Cleveland, Ohio 44113



May 12, 2014

Doors open 5:30 - 9:30 PM

(Limited menu available for purchase before and during the event. Not to mention beer! Last call is at 8:45 PM)

Discussion starts around 7:00 p.m.


*Please Note* A few of our cafes have approached capacity and/or standing room only. If you want to be 100% sure to get in and get a good seat, you might want to arrive a bit early.


WHO: Sponsored by Case Western Reserve University chapter of Sigma Xi, WCPN ideastream, and Great Lakes Brewing Company