Science Café Cleveland presents


New Discoveries in the Biology and Treatment of Breast Cancer


APRIL 13, 2015




Ruth Keri, PhD

Professor and Vice Chair, Department of Pharmacology, Associate Director for Basic Research, Case Comprehensive Cancer Center




William P. Schiemann, PhD

Professor, General Medicine Sciences (Oncology), Case Western Reserve University, Co-Leader, Breast Cancer Program, Case Comprehensive Cancer Center






The story of breast cancer treatment is one that swings between hope and disappointment. While mammography and chemotherapy produced a dramatic 24% decrease in breast cancer mortality between 1990-2000, this positive trend in survival plateaued over the last decade, and metastatic breast cancer remains the 2nd most prevalent cancer-related killer of women in the United States, annually accounting for more than 40,000 deaths and 227,000 new case of invasive breast cancer.
In discussing the treatment of breast cancer, Hippocrates stated that “Those diseases that medicines do not cure are cured by the knife. Those that the knife does not cure are cured by fire. Those that fire does not cure must be considered incurable.” Metastatic disease is typically incurable and highly resistant to contemporary “fire” treatments and chemotherapies, leading legendary cancer biologist Dr. Robert A. Weinberg to pronounce metastasis as “The Last Frontier in Cancer Research.”
The presentation will explore several critical issues related to breast cancer metastasis, such as: Why do breast cancers metastasize and often remain dormant in a ‘suspended state of animation’ for many years before awakening as incurable lesions? Is there a logical evolution to treatment resistance, and if so, can we use this knowledge to personalize patient treatments? Are there co-conspirators that aid and abet breast cancer cells during metastasis, and if so, can their inactivation by novel treatments improve the overall survival of breast cancer patients?




The Tasting Room at Great Lakes Brewing Company

2701 Carroll Avenue

Cleveland, Ohio 44113



April 13, 2015

Doors will be open 5:30 - 9:00 PM (Last call at 8:45PM). Presentation and discussion is 7:00 - 8:00 PM. The Tasting Room will also host a limited menu before and during the event. Not to mention beer! (Click here to view menu).


*Please Note* A few of our cafes have approached capacity and/or standing room only. If you want to be 100% sure to get in and get a good seat, you might want to arrive a bit early.


WHO: Sponsored by Case Western Reserve University chapter of Sigma Xi, WCPN ideastream, and Great Lakes Brewing Company



Click here to download a pdf flyer of the event