The Protocol Review and Monitoring Committee (PRMC) is responsible for the Case Comprehensive Cancer Center's Protocol Review and Monitoring System. The PRMC reviews all new cancer-related trials conducted at the institutions affiliated with the Case CCC, and also provides feedback to assist in protocol development. All trials that include drugs, devices and behavioral interventions, as well as prospective observational studies, such as survey studies, are required to be submitted and reviewed by the PRMC. Studies that involve prospective tissue research also require review by the PRMC. (Further definitions for study types can be found on the PRMC application, question 13).
The PRMC plays a critical role in protocol review and monitoring to assure that clinical trials are scientifically sound, and that approved studies maintain adequate patient accrual and scientific progress.
PRMC membership represents a variety of disciplines including medical oncology, pediatric oncology, gynecologic oncology, radiation oncology, surgical oncology, psychosocial oncology, nursing, investigational pharmacy, cancer prevention and control, social and behavioral, data management, biostatistics, and laboratory science, with representations from each consortium institution. The Committee also includes community representatives.
PRMC Meeting Documents (password protected)
PRMC Forms for Investigators and Study Teams
PRMC Documents for Disease Teams
PRMC Forms for Reviewers
- Primary Review Sheet (full for IIT)
- Primary Review Sheet (limited for Pharma)
- Statistical Sign-off Sheet
- Pharmacy Review
- Nursing Sign-off Sheet
- Patient Advocate Review Sheet