Request for Proposals for the GI SPORE Career Enhancement Program Award (CEP)

The Case Comprehensive Cancer Center's Specialized Program of Research Excellence in Gastrointestinal Malignancies (GI SPORE) invites all faculty members to submit proposals to be considered for the SPORE Career Enhancement Program Award (CEP). All proposals must be directed toward translational research of a GI malignancy with at least one specific aim that involves the direct study of patients or human materials.

Awards may be funded up to $50,000 in direct costs for one year each with the possibility of second-year funding pending outstanding progress and development, subject to competitive review with all other CEP proposals submitted at that time.

Proposal Guidelines

  1. Biographical sketch of the applicant with bibliography in NIH format
  2. Personal statement of long-term career goals, interests in translational research and past experience including abstract of dissertation, post-doctoral and/or clinical fellowship training (2 pages)
  3. Research Proposal (5 pages maximum) excluding references
    • Specific aims (1 page)
    • Background and significance (1 1/2 pages)
    • Experimental design and methods (2 1/2 pages)
    • Literature cited (does not count toward the 5-page limit)
  4. NIH biographical sketch of the research mentor
  5. Letter of commitment from research mentor to the translational research project and research mentoring
  6. Letter from department head with commitment to faculty position with 75% protected time for research and training for 2 years as SPORE Career Enhancement Research Scholar
  7. Letters of Recommendation from 3 individuals knowledgeable about the candidate's clinical, research performance, commitment to a research career and potential for a successful career in GI cancer translational research. One letter must be from the anticipated department head at Case Western Reserve University (CWRU)

Project Eligibility

  1. Individuals with junior faculty appointments at all CWRU affiliated institutions, including Cleveland Clinic (CCF), University Hospitals Cleveland Medical Center (UHCMC), MetroHealth and VA, at the instructor or assistant professor level who have not previously served as principal investigator on a NIH Research Program Grant (i.e., R01s), first awards (i.e., R24s), or comparative development awards (i.e., K01, K07, K08, K12, K23); or,
  2. Advanced post-doctoral or clinical fellows with commitments to independent faculty appointments at CWRU by the beginning of CEP award
  3. Established investigators with faculty appointments at CWRU who seek to refocus their research on GI translational cancer research
  4. Individuals in any of the above categories at other institutions must secure a commitment to a CWRU faculty position by the time program participation is scheduled to begin
  5. All candidates must hold a terminal degree, MD, DO, PhD or equivalent and have completed training by the time program participation is scheduled to begin
  6. Candidates must provide a letter from their department chair that guarantees they will have a minimum of 75% full-time professional effort protected for research and training in the CEP during the period of this award.
  7. All candidates must be US citizens or non-citizen nationals or must be lawfully admitted for permanent residence and possess an Alien Registration Receipt card or other verification of legal admission as a permanent resident of the United States. Foreign nationals and individuals in temporary or student visas are not eligible.


Completed proposals must be submitted via InfoReady by May 15, 2021. Previously submitted SPORE pilot/scholar applications are welcome to be resubmitted. For questions, please contact

View application instructions

More information on the GI SPORE