Annual Scientific Retreat Agenda

Thursday, JULY 22

All are welcome to attend. Please register to receive virtual retreat access.

12:00 – 12:15 PM

"Year of Accomplishments"
Stan Gerson, MD
Director, Case Comprehensive Cancer Center 

12:15 – 1:15

TED-style Talks

"Becoming a More Inclusive Leader"
Diana Bilimoria, PhD
KeyBank Professor and Chair, Organizational Behavior, Weatherhead School of Management, Case Western Reserve University

"Purpose with Pure Intent"
Daniel E. Spratt, MD
Vincent K. Smith Chair in Radiation Oncology, Seidman Cancer Center, University Hospitals

"Generations and Medicine"
Serpil Erzurum, MD
Chief Research & Academic Officer, Cleveland Clinic

1:15 – 1:25 Break
1:25 – 2:30

Session I: Metabolomics

Moderators: Abhishek Chakraborty, PhD
Planning Committee Member, Cancer Genomics Program, Case Comprehensive Cancer Center, Cleveland Clinic
Kristina Austin
Director of Community Engagement, Case Comprehensive Cancer Center

"Cyclin D1 and Glutamine Dependence in Cancer"
Alan Diehl, PhD
Deputy Director and Chief Operating Officer, Case Comprehensive Cancer Center

Trainee Invited Presentation: "Glioblastoma Acquires Mitochondria from the Tumor Microenvironment that Augment Tumorigenicity"
Dionysios Watson, MD, PhD
Mentor: Justin Lathia, PhD, Cleveland Clinic

"Malignant ER Proteostasis in Breast Cancer"
Maria Hatzoglou, PhD 
Member, Molecular Oncology Program, Case Comprehensive Cancer Center, Case Western Reserve University

Panel/Q&A

2:30 – 4:00

Poster Session

Poster Presenters have been split into 2 sessions (2:30-3:15 and 3:15-4:00pm). To join the Poster Session, go to the Agenda on the left-hand menu in Whova and find the Poster Session listed on Day One. You then ‘View Session’ to choose which Poster Session you would like to join. This will then take you to the Zoom to interact with the Poster Presenters in Breakout Rooms.

*Posters and abstracts are available for viewing at any time in Whova, so check out which poster presenters you would like to visit with during the poster session!

Friday, JULY 23

Members and trainees only. Please register to receive virtual retreat access.

8:00 – 8:30 AM

"Strategic Directions"
Stan Gerson, MD
Director, Case Comprehensive Cancer Center 

8:30 – 9:35

Session II: Therapeutic Translation

Moderators: Omar Mian, MD, PhD
Member, Developmental Therapeutics Program, Case Comprehensive Cancer Center, Cleveland Clinic
Francis Mills
Member, Community Advisory Board, Case Comprehensive Cancer Center

"Role of Piwil1 in Glioma Stem Cell Maintenance and Glioblastoma Progression"
Jennifer Yu, MD, PhD
Co-Leader, Developmental Therapeutics Program, Case Comprehensive Cancer Center, Cleveland Clinic

Trainee Invited Presentation: ''Therapeutic Targeting of Protein Disulfide Isomerase PDIA1 in Multiple Myeloma"
Metis Hasipek, PhD
Mentor: Babal Jha, PhD, Cleveland Clinic

"Select Stabilization of a Tumor Suppressive PP2A Heterotrimer"
Derek Taylor, PhD
Member, Developmental Therapeutics Program, Case Comprehensive Cancer Center, Case Western Reserve University

Panel/Q & A

9:35 – 9:45 Break
9:45 – 10:50

Session III: Immuno-oncology

Moderators: Lily Wang, PhD
Planning Committee Member, Case Comprehensive Cancer Center, Case Western Reserve University
Michele Seyranian
Member, Community Advisory Board, Case Comprehensive Cancer Center

"BG34-200 Engagement with Integrin CD11b Inducing Myeloid Cell Modulation for Immunotherapy of Pancreatic Ductal Adenocarcinoma"
Mei Zhang, PhD
Member, Developmental Therapeutics Program, Case Comprehensive Cancer Center, Case Western Reserve University

Trainee Invited Presentation: "Sequential Single-cell Transcriptional and Protein Marker Profiling Reveals TIGIT as a Marker of CD19 CAR-T Cell Dysfunction in Patients with Non-Hodgkin’s Lymphoma"
Zachary Jackson, PhD
Mentor: David Wald, MD, PhD, University Hospitals

"Single-Cell Sequencing Defines a High OXPHOS CD8+ T cell Subset Predictive of Immunotherapy Resistance"
Brian Gastman, MD
Member, Immune Oncology Program, Case Comprehensive Cancer Center, Cleveland Clinic

Panel/Q & A

10:50 – 11:40

Keynote Presentation: "Targeting GARP-TGFB-beta Pathway for Cancer Immunotherapy: Opportunities and Challenges"

Zihai Li, MD, PhD
Founding Director, Pelotonia Institute for Immuno-Oncology and the Klotz Chair in Cancer Research, The Ohio State University

11:40 – 12:55

Research Program/Trainee Breakouts

Registered attendees will be assigned to breakout rooms in Zoom for their programs.

12:55 – 2:00

Session IV: Local/Global Risks 

Moderators: Jennifer Cullen, PhD, MPH
Planning Committee Member, Associate Director for Cancer Population Sciences, Case Comprehensive Cancer Center, Case Western Reserve University 
Cheryl Davis
Member, Community Advisory Board, Case Comprehensive Cancer Center

"Uganda-Tanzania-CWRU HIV-associated Cancer Research Program"
Robert Salata, MD
Member, Population and Cancer Prevention Program, Case Comprehensive Cancer Center, University Hospitals

Trainee Invited Presentation: "Investigating Geographic Patterns of Aggressive Tumor Subtypes: Integrating social and environmental mechanisms to understand biological outcomes"
Anna Miller, PhD
Mentor: Stefanie Avril, MD, University Hospitals

Kristine Zanotti, MD
Member, Population and Cancer Prevention Program, Case Comprehensive Cancer Center, University Hospitals

Panel/Q & A

2:00 – 2:10 Break
2:10 – 3:15

Session V: Epigenetics/Genetics

Moderators: Hanna Heemers, PhD
Member, Developmental Therapeutics Program, Case Comprehensive Cancer Center, Cleveland Clinic
Gina Chicotel
Member, Community Advisory Board, Case Comprehensive Cancer Center

"Chromatin Drivers in Cancer"
Berkley Gryder, PhD
Assistant Professor, Case Comprehensive Cancer Center, Case Western Reserve University

Trainee Invited Presentation: "The Extraction and Validation of the Cisplatin Sensitivity Signature"
Jessica Scarborough, MS
Mentor: Jacob Scott, MD, PhD, Cleveland Clinic

"Therapeutic Targeting of Malignant Cell Vulnerabilities"
Babal Jha, PhD
Member, Developmental Therapeutics Program, Case Comprehensive Cancer Center, Cleveland Clinic

Panel/Q & A

3:15 – 3:30 Wrap-up
3:30 – 4:30 Program Leaders/Executive Committee closed session