GI Cancer Genetics

Program Focus Areas

The GI Cancer Genetics Program is organized around three broad scientific Focus Areas:

  • Discovery and clinical translation of genetic alterations in GI cancers
  • Discovery and clinical translation of epigenetic changes in GI cancers
  • Development of novel methods and models to facilitate basic and translational GI cancer research

These Focus Areas intersect with a specific disease emphasis on gastrointestinal cancers, particularly colon cancers and adenocarcinomas of the esophagus, but have also led to significant advances in understanding other tumors including human sarcomas, brain and breast tumors.

Program Information

The leaders of the GI Cancer Genetics Program established an internationally recognized team science-oriented program deciphering the genetic origins of cancers with a focus particularly in colon cancers and adenocarcinomas of the esophagus, but have also led to significant advances in understanding other tumors including human sarcomas.

The Program is supported by numerous multi-investigator grants, including a newly awarded GI SPORE, and program members have made multiple seminal observations and discoveries that include finding: causative genes for colon cancer, a molecular screening test for colon cancer, and alterations in histone methylation at target gene enhancers that acts as an epigenetic signature of colon cancer.

Program Members

  • Portrait of Andrew Blum

    Andrew Blum, MD, PhD

    Assistant Professor
    Department of Medicine
    School of Medicine
    Member
    GI Cancer Genetics Program
    Case Comprehensive Cancer Center

    Email: andrew.blum@case.edu

    Phone: 216.791.3800

  • Image of Henri Brunengraber

    Henri Brunengraber, MD, PhD

    Professor
    Department of Nutrition
    School of Medicine
    Professor
    Department of Biochemistry
    School of Medicine
    Member
    Case Comprehensive Cancer Center

    Email: henri.brunengraber@case.edu

    Phone: 216.368.6548

  • Portrait of Amitabh Chak, MD

    Amitabh Chak, MD

    Professor
    Department of Medicine
    School of Medicine
    Member
    GI Cancer Genetics Program
    Case Comprehensive Cancer Center

    Email: Amitabh.Chak@uhhospitals.org

    Phone: 216.844.3217

  • Portrait of Stephen Fink

    Stephen P. Fink, PhD

    Assistant Professor
    Case Comprehensive Cancer Center
    Member
    GI Cancer Genetics Program
    Case Comprehensive Cancer Center

    Email: stephen.fink@case.edu

    Phone: 216.368.5657

  • Portrait of Claudio Fiocchi

    Claudio Fiocchi, MD

    Professor
    Department of Molecular Medicine
    School of Medicine
    Professor
    Department of Inflammation and Immunity
    School of Medicine
    Member
    GI Cancer Genetics Program
    Case Comprehensive Cancer Center

    Email: fiocchc@ccf.org

    Phone: 216.445.0895

  • Portrait of Kishore Guda
    David Schwartz Photography

    Kishore Guda, DVM, PhD

    Associate Professor
    Case Comprehensive Cancer Center
    Associate Professor
    Digestive Health Research Institute
    School of Medicine
    Member
    GI Cancer Genetics Program
    Case Comprehensive Cancer Center

    Email: gkishore@yahoo.com

    Phone: 216.368.5665

  • Emina Huang, MD

    Professor
    Department of Surgery
    School of Medicine
    Member
    GI Cancer Genetics Program
    Case Comprehensive Cancer Center

    Email: huange2@ccf.org

    Phone: 216.442.5097

  • Image of headshot of Sudha K. Iyengar

    Sudha K. Iyengar, PhD

    Professor and Vice Chair for Research
    Department of Population and Quantitative Health Sciences
    School of Medicine
    Professor
    Department of Genetics and Genome Sciences
    School of Medicine
    Professor
    Department of Ophthalmology and Visual Sciences
    School of Medicine
    Member
    GI Cancer Genetics Program
    Case Comprehensive Cancer Center

    Email: sudha.iyengar@case.edu

    Phone: 216.368.4388

  • Matthew Kalady, MD

    Professor
    Department of Surgery
    School of Medicine
    Member
    GI Cancer Genetics Program
    Case Comprehensive Cancer Center

    Email: kaladym@ccf.org

  • Portrait of Mehmet Koyuturk

    Mehmet Koyutürk , PhD

    Professor
    Department of Electrical Engineering and Computer Science
    Case School of Engineering
    Member
    GI Cancer Genetics Program
    Case Comprehensive Cancer Center

    Email: mxk331@case.edu

    Phone: 216.368.2963

  • Headshot Thomas LaFramboise

    Thomas LaFramboise, PhD

    Associate Professor
    Department of Genetics and Genome Sciences
    School of Medicine
    Member
    GI Cancer Genetics Program
    Case Comprehensive Cancer Center

    Email: thomas.laframboise@case.edu

    Phone: 216.368.0150

  • Portrait of Sanford Markowitz

    Sanford Markowitz, MD, PhD

    Ingalls Professor of Cancer Genetics
    Department of Medicine
    School of Medicine
    Professor
    Department of Genetics and Genome Sciences
    School of Medicine
    Professor
    Department of Molecular Biology and Microbiology
    School of Medicine
    Principal Investigator
    Case GI SPORE
    Case Comprehensive Cancer Center
    Co-Leader
    GI Cancer Genetics Program
    Case Comprehensive Cancer Center

    Email: sxm10@case.edu

    Phone: 216.844.3951

  • Headshot of Christopher McFarland

    Christopher McFarland, PhD

    Assistant Professor
    Department of Genetics and Genome Sciences
    School of Medicine
    Assistant Professor
    Case Comprehensive Cancer Center
    School of Medicine
    Member
    GI Cancer Genetics Program
    Case Comprehensive Cancer Center

    Email: christopher.mcfarland@case.edu

    Phone: 216.368.3286

  • Alexander Miron, PhD

    Alexander Miron, PhD

    Director
    Genomics Core
    School of Medicine
    Associate Professor
    Department of Genetics and Genome Sciences
    School of Medicine
    Member
    GI Cancer Genetics Program
    Case Comprehensive Cancer Center

    Email: alexander.miron@case.edu

    Phone: 216.368.2791

  • Headshot of Peter Scacheri

    Peter C. Scacheri, PhD

    Professor
    Department of Genetics and Genome Sciences
    School of Medicine
    Member
    GI Cancer Genetics Program
    Case Comprehensive Cancer Center

    Email: peter.scacheri@case.edu

    Phone: 216.368.3458

  • Head shot of Paul Tesar

    Paul J. Tesar, PhD

    Professor
    Department of Genetics and Genome Sciences
    School of Medicine
    Professor
    Department of Neurosciences
    School of Medicine
    Member
    GI Cancer Genetics Program
    Case Comprehensive Cancer Center
    Member
    Molecular Oncology Program
    Case Comprehensive Cancer Center
    Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics
    Department of Genetics and Genome Sciences
    School of Medicine

    Email: paul.tesar@case.edu

    Phone: 216.368.6225

  • Image of Vinay Varadan.

    Vinay Varadan, PhD

    Assistant Professor
    Case Comprehensive Cancer Center
    Member
    GI Cancer Genetics Program
    Case Comprehensive Cancer Center

    Email: vxv89@case.edu

    Phone: 216.368.2194

  • Portrait of Zhenghe John Wang

    Zhenghe J Wang, PhD

    Vice Chair for Faculty Development
    Department of Genetics and Genome Sciences
    School of Medicine
    Dale H. Cowan M.D. – Ruth Goodman Blum Professor of Cancer Research
    Professor
    Department of Genetics and Genome Sciences
    School of Medicine
    Co-Leader
    GI Cancer Genetics Program
    Case Comprehensive Cancer Center

    Email: zhenghe.wang@case.edu

    Phone: 216.368.0446

  • Anthony Wynshaw-Boris, MD, PhD Professor of Genetics and Chair, Department of Genetics and Genome Sciences at Case Western Reserve University School of Medicine; Director of ICARE

    Anthony Wynshaw-Boris, MD, PhD

    Professor and Chair
    Department of Genetics and Genome Sciences
    School of Medicine
    James H. Jewell MD ’34 Professor of Genetics
    Department of Genetics and Genome Sciences
    School of Medicine
    Professor
    Department of Neurosciences
    School of Medicine
    Professor
    Department of Pediatrics
    School of Medicine
    Member
    GI Cancer Genetics Program
    Case Comprehensive Cancer Center

    Email: anthony.wynshaw-boris@case.edu

    Phone: 216.368.0581

  • Dr. Lan Zhou

    Lan Zhou, MD, PhD

    Professor
    Department of Pathology
    School of Medicine
    Member
    GI Cancer Genetics Program
    Case Comprehensive Cancer Center

    Email: lan.zhou@case.edu

    Phone: 216.368.1671