GU Malignancies

Program Themes

  • Discover mechanisms of response and resistance in prostate and renal cancer
  • Develop novel biomarkers across GU malignancies
  • Ascertain the immunomodulatory environment and develop novel immunotherapeutic clinical trials 

Program Information

The overarching goal of the GU Malignancies Program is to explore fundamental biologic pathways of critical importance to the development and progression of prostate and renal cancer and to foster translational, investigator-initiated clinical trials to advance therapeutic options.

To provide additional structure and promote cohesion within the larger Program, investigators have been further organized around two scientific focus areas:

  • Prostate Cancer - includes genetic susceptibility and molecular basis, chemoprevention, molecular biomarkers of prognosis and therapeutic targeting of the IGF and PI3K/Akt/mTOR axis
  • Renal Cancer - includes molecular and clinical biomarkers of prognosis, response and resistance; immunomodulatory effects of treatment, and therapeutic targeting of angiogenesis and the PI3K/Akt/mTOR axis

Program Members

  • Portrait of Tatiana Byzova

    Tatiana V. Byzova, PhD

    Assistant Professor
    Department of Molecular Medicine
    School of Medicine
    Member
    GU Malignancies Program
    Case Comprehensive Cancer Center

    Email: byzovat@ccf.org

    Phone: 216.445.4312

  • Portrait of Abhishek Chakraborty

    Abhishek A. Chakraborty, PhD

    Assistant Professor
    Department of Molecular Medicine
    School of Medicine
    Member
    GU Malignancies Program
    Case Comprehensive Cancer Center

    Email: chakraa@ccf.org

    Phone: 216.445.6620

  • Claudia M. Diaz-Montero, PhD

    Adjunct Assistant Professor
    Department of Molecular Medicine
    School of Medicine
    Member
    GU Malignancies Program
    Case Comprehensive Cancer Center

    Email: diazc@ccf.org

  • Image of headshot of Ann Harris

    Ann Harris, PhD

    Vice Chair of Research
    Department of Genetics and Genome Sciences
    School of Medicine
    Professor
    Department of Genetics and Genome Sciences
    School of Medicine
    Member
    GU Malignancies Program
    Case Comprehensive Cancer Center

    Email: ann.harris@case.edu

    Phone: 216.368.6651

  • Portrait of Tae Hyun Hwang

    Tae Hyun Hwang, PhD

    Assistant Professor
    Molecular Medicine
    School of Medicine
    Member
    GU Malignancies Program
    Case Comprehensive Cancer Center

    Email: hwangt@ccf.org

    Phone: 216.442.5565

  • Byron Lee, MD, PhD

    Assistant Professor
    Department of Surgery
    School of Medicine
    Member
    GU Malignancies Program
    Case Comprehensive Cancer Center

    Email: leeb4@ccf.org

  • Robert H. Silverman

    Robert H. Silverman , PhD

    Professor
    Department of Molecular Medicine
    School of Medicine
    Professor
    Department of Biochemistry
    School of Medicine
    Member
    GU Malignancies Program
    Case Comprehensive Cancer Center

    Email: silverr@ccf.org

    Phone: 216.445.9650

  • Portrait of Angela Ting

    Angela H. Ting, PhD

    Associate Professor
    Department of Molecular Medicine
    School of Medicine
    Assistant Professor
    Department of Genetics and Genome Sciences
    School of Medicine
    Member
    GU Malignancies Program
    Case Comprehensive Cancer Center

    Email: tinga@ccf.org

    Phone: 216.444.0682