Chad Zender, MD

Associate Professor
Department of Otolaryngology
School of Medicine
Associate Professor
Department of Biological Sciences
School of Dental Medicine
Cancer Prevention
Control & Population Research Program
Case Comprehensive Cancer Center

Dr. Zender is a surgeon in the UH Ear, Nose & Throat Institute at University Hospitals and has dual appointment as an Associate Professor in the Schools of Medicine and Dental Medicine. His research interests involve clinical trials utilizing non-surgical treatment of HPV-related head and neck cancer, targeted therapies as adjuvant therapy after surgery, and identifying biomarkers for targeted therapies and identification of cancerous and precancerous lesions in the head and neck.

Research Information

Research Interests

  • Head and Neck Cancer
  • Microvascular Surgery
  • TransOral Laser Microsurgery, Melanoma
  • Skull Base Surgery
  • TransOral Robotic Surgery (TORS)
  • Head and Neck Reconstruction
  • Thyroid Cancer

External Appointments

Surgeon, UH Ear, Nose & Throat Institute, Department of Otolaryngology, Head and Neck
University Hospitals Seidman Cancer Center


View All Publications

Selected Publications

Wick, C. C., Rezaee, R. P., & Zender, C. A. (2012). Piezoelectric BoneScalpel osteotomies in osteocutaneous free flaps. Laryngoscope. 2013 Mar;123(3):618-21. doi: 10.1002/lary.23740. Epub 2012 Sep 24. PMID:23007609

Schmitt AR, Zender CA, Bordeaux JS:  A new oral anticoagulant in the setting of dermatologic surgery. J Am Acad Dermatol. 2013 May;68(5):869-70. doi: 10.1016/j.jaad.2012.07.036. PMID:23602176

Zender CA, Mehta V, Pittman AL, Feustel PJ, Jaber JJ. Etiologic causes of late osteocutaneous free flap failures in oral cavity cancer reconstruction. Laryngoscope. 2012 Mar 28. doi: 10.1002/lary.23326. [Epub ahead of print] PMID:22565542

Yao, M., Lu, M., Savvides, P. S., Rezaee, R., Zender, C. A., Lavertu, P., ... & Machtay, M. (2011). Distant metastases in head-and-neck squamous cell carcinoma treated with intensity-modulated radiotherapy. International Journal of Radiation Oncology* Biology* PhysicsPMID:22169673

Leonetti, J.P., Marzo, S.J., Zender, C.A., et al., Temporal Bone Osteoradionecrosis After Surgery and Radiotherapy for Malignant Parotid Tumors. Otology & Neurotology:  June 2010 - Volume 31 - Issue 4 - pp 656-659 PMID:20964249

Jaber, J. J., Clark, J. I., Muzaffar, K., Ruggiero, F. P., Feustel, P. J., Frett, M. J. and Zender, C. A. , Evolving treatment strategies in thin cutaneous head and neck melanoma: 1 institution's experience. Head Neck. 2011 Jan;33(1):7-12. doi: 10.1002/hed.21403. PMID:20848424

John P. Leonetti, MD, Chad A. Zender, MD, Daryl Vandevender, MD, and Sam J. Marzo, MD Long-term results of microvascular free-tissue transfer reanimation of the paralyzed face: three cases Ear Nose Throat J. 2008 Apr;87(4):226-9, 233. PMID:18478799

Schrementi ME, Ferreira AM, Zender C, Dipietro LA.  Site-specific production of TGF-beta in oral mucosal and cutaneous wounds.  Wound Repair Regen. 2008 Jan-Feb;16(1):80-6. PMID:18086295

Sitole S, Zender CA, Ahmad AZ, Hammadeh R, Petruzzelli GJ. Lacrimal sac melanoma.  Ophthal Plast Reconstr Surg. 2007 Sep-Oct;23(5):417-9. PMID:17882000

Zender CA, Petruzzelli GJ: Why do patients with head and neck carcinoma develop distant metastasis, and can they be prevented? Current Opinion in Oto-H&N Surg.  2005, 13:101-104.

Zender CA, Petruzzelli GJ: The Skull Base, Paranasal Sinuses and Related Malignancies. Current Oncology Reports 2003 5:147-151 PMID:12583832

Marzo, Sam J; Zender, Chad A; Leonetti, John P. Facial nerve schwannoma. Current Opinion in Otolaryngology & Head & Neck Surgery:  October 2009 - Volume 17 - Issue 5 - p 346-350 PMID:19561500

Zender CA, Petruzzelli GJ: Skin grafting in oral cavity reconstruction. Operative Techniques in Oto-H&N Surg. 2005, 16:24-27

Provost TL. Juarez de Ku LM. Zender C. Meserve LA. Dose- and age-dependent alterations in choline acetyltransferase (ChAT) activity, learning and memory, and thyroid hormones in 15- and 30-day old rats exposed to 1.25 or 12.5 PPM polychlorinated biphenyl (PCB) beginning at conception. [Journal Article] Progress in Neuro-Psychopharmacology & Biological Psychiatry. 23(5):915-28, 1999 Jul.


Doctor of Medicine
Wright State University Boonshoft School of Medicine
Master of Science
Bowling Green State University

Residencies, Internships and Fellowships

Fellowship, Microvascular Surgery
Vanderbilt University Medical Center
Residency, Otolaryngology
Loyola University Medical Center

Additional Information


American Board of Otolaryngology