The underlying principle of Dr. Greenfield’s research is to study the cellular and molecular mechanisms that regulate clinically important aspects of bone biology. The long-term goal is to understand these processes in sufficient detail to help develop novel diagnostics and therapeutics. With this goal in mind, Dr. Greenfield have three active areas of research:
- Osseointegration and aseptic loosening of orthopaedic implants. These studies focus on determining whether bacteria impair osseointegration and whether bacteria contribute to aseptic loosening. Dr. Greenfield also conducts studies to develop counter-measures for impaired osseointegration.
- The balance between the catabolic and anabolic effects of parathyroid hormone. These studies focus on the regulation by Protein Kinase Inhibitor gamma of intracellular signaling pathways induced by parathyroid hormone.
- Tumorigenesis and metastasis in osteosarcoma. These studies focus on the roles of tyrosine kinases and miRNAs.