Mukesh Jain, MD

Department of Medicine
School of Medicine
Cardiovascular Research Institute
School of Medicine
Department of Physiology and Biophysics
School of Medicine
Developmental Therapeutics Program
Case Comprehensive Cancer Center

Research Information

Research Interests

I have been involved in cardiovascular research as Principal Investigator for 13 years. My laboratory is recognized for studies highlighting the role of a family of factors termed Kruppel-like factors (KLFs) in diverse biological processes. Specifically, our efforts have identified key regulatory roles for KLFs in cardiovascular biology, systemic metabolic homeostasis, and innate immunity. These discoveries have opened new areas of investigation and contributed to growing appreciation that KLFs are nodal regulators of cellular homeostasis and tissue function. This work has led to publications in top-tier journals including Nature, Cell Metabolism, Nature Communications, Science Translational Medicine, Immunity, PNAS, Journal of Clinical Investigation, and Journal of Experimental Medicine.

I also have a long track record of successfully training independent investigators. I have had the opportunity to successfully mentor a number of individuals, many of whom have been fortunate recipient of NIH K-grants (total 16), and numerous AHA post-doctoral fellowships/NIH F32/foundation fellowships. Many of these individuals have established independent research programs with R-level funding at leading academic medical centers including Harvard Medical School, University of Massachusetts, University of Pittsburgh, Ohio State University, Case Western Reserve University, and the University of Tokyo. I am recipient of mentoring awards from Harvard Medical School and Case Western Reserve University. I have also served as PI of an NIH T32 grant focused on training of pre-doctoral and post-doctoral candidates.

Finally I have had a number of leadership roles both locally and nationally. At my home institution I current serve as Chief Scientific Officer for University Hospital Health System and Vice-Dean for Medical Sciences at Case Western Reserve University. Nationally, I recently served as President of the America Society for Clinical Investigation (ASCI), one of the oldest and most prestigious honorific societies for physician-scientists.

Professional Memberships

National Academy of Medicine, 2016
President, American Society for Clinical Investigation, 2014
President-elect, American Society for Clinical Investigation, 2013
Vice President, American Society for Clinical Investigation, 2012

External Appointments

Chief Scientific Officer
Harrington Discovery Institute, University Hospitals
Chief Research Officer
University Hospitals Harrington Heart & Vascular Institute
Chief Academic Officer
University Hospitals Health System
Founding Director
University Hospitals Research Division
  • 2010: Chair, Vascular Cell and Molecular Biology, Study Section, NIH
  • 2004-2006: Assistant Professor, Cardiovascular Division, Brigham & Women's Hospital, Harvard Medical School
  • 2004-2006: Director, Program in Cardiovascular Transcriptional Biology, Brigham & Women's Hospital, Harvard Medical School
  • 2000-2004:  Instructor, Cardiovascular Division, Brigham & Women's Hospital, Harvard Medical School


View All Publications

Below are the original four publications that provided the early links between KLFs and metabolism, cardiovascular biology, and innate immunity. In the section of “Contributions to Science” I provide a more detailed summary and more recent publications.

Selected List of Publications


Doctor of Medicine
University of Buffalo School of Medicine
Bachelor of Science
University of Buffalo

Residencies, Internships and Fellowships

Cardiology Fellow
Cardiovascular Division, Brigham & Women's Hospital, Harvard Medical School
Research Fellow
Harvard School of Public Health, Harvard Medical School
Beth Israel Hospital, Dept. of Medicine, Harvard Medical School