Nima Sharifi, MD

Professor
Department of Molecular Medicine
School of Medicine
Co-Leader
GU Malignancies Program
Case Comprehensive Cancer Center

Research Information

Research Projects

Our laboratory is focused on steroid metabolism and androgen receptor (AR) function as it relates to prostate cancer. The first line of therapy for metastatic prostate cancer is androgen deprivation therapy (ADT), which blocks the release of gonadal testosterone and suppresses intratumoral concentrations of the most potent androgen, dihydrotestosterone (DHT).  However, metastatic disease eventually becomes resistant to ADT. Prostate cancer that progresses in the face of ADT is termed castration-resistant prostate cancer (CRPC) and is frequently driven by tumors acquiring the capability of making their own DHT.  We study how this process occurs.  Our most important discoveries include identification of the first mutation in the androgen synthesis machinery that is responsible for increasing DHT synthesis in CRPC and demonstration that DHT synthesis in patients with CRPC follows a pathway that circumvents testosterone.  We are currently applying these findings to the study of CRPC as it occurs in patients.

External Appointments

Staff, Department of Cancer Biology
Lerner Research Institute, Cleveland Clinic

Publications

Additional Information