Rafick-Pierre Sékaly, PhD

Department of Pathology
The Center for Systems Immunology
School of Medicine
Hematopoietic and Immune Cancer Biology Program
Case Comprehensive Cancer Center

Dr. Rafick-Pierre Sekaly is the Richard J. Fasenmyer Professor of Immunopathogenesis, Co-Director of the Center of Systems Immunology (CSI), and Co-director of the Center for AIDS Research (CFAR) Proteomics and Systems Biology Core at Case Western Reserve University.

 His research group has been continuously funded since 1988 by federal and nonfederal grants. He is the principal investigator on numerous grants from the National Institutes of Health, the Bill and Melinda Gates Foundation, the American Foundation for AIDS Research, the Fred Hutchinson Cancer Research Center, Gilead Sciences Incorporation, Merck Sharp & Dohme Corporation, and more.

His focus on HIV disease immune pathogenesis, immune virology, and immunotherapies has generated pioneering findings that highlight the impact of HIV infection on thymic output, T cell memory, mechanisms of CD4 and CD8 T cell dysfunction, and on innate immunity and mechanisms of HIV persistence. He has also pioneered the use of transcriptomics and bioinformatics to identify predictors/correlates of immune responses that lead to protection from viral infections, including HIV, SIV and flaviviruses, protection from disease progression and successful immune interventions including adjuvants, licensed preventative and therapeutic vaccines.  

 Dr. Sekaly’s efforts resulted in novel approaches to cancer and HIV vaccines and have led to more than 340 peer-reviewed articles in scientific journals and 25 patents in Adjuvants, PD-1 and vaccine vectors.