Rose Chu Beck, MD, PhD

Assistant Professor
Department of Pathology
School of Medicine
Member
Hematopoietic and Immune Cancer Biology Program
Case Comprehensive Cancer Center

Research Information

Research Interests

Clinical

  • Hematopathology
  • Molecular Hematology
  • Laboratory Hematology

Research

  • Molecular/genetic findings in hematopoietic neoplasms
  • Flow cytometry diagnosis of hematopoietic neoplasms

External Appointments

Director
UHLSF-Westlake, UH Cleveland Medical Center
Director, Hematopathology Fellowship program
UH Cleveland Medical Center

Publications

View All Publications

  1. Griffin JP, Chu R, Harding CV: Early endosomes and a late endocytic compartment generate different peptide-class II MHC complexes via distinct processing mechanisms.  J Immunol 1997; 158:1523-1532.
  2. Chu RS, Targoni OS, Krieg AM, Lehmann PV, Harding CV: CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J Exp Med 1997; 186:1623-1631.
  3. Chu RS, Askew D, Noss EH, Tobian A, Krieg AM, Harding CV: CpG oligodeoxynucleotides down-regulate macrophage class II MHC antigen processing.  J Immunol  1999; 163:1188-1194.
  4. Ramachandra L, Chu RS, Askew D, Noss EH, Canaday DH, Potter NS, Johnsen A, Krieg AM, Nedrud JG, Boom WH, Harding CV: Phagocytic antigen processing and effects of microbial products on antigen processing.  Immunological Rev 1999; 168: 217-239.
  5. Chu RS, Askew D, Harding CV: CpG DNA switches on Th1 immunity and modulates antigen presenting cell function.  Curr Top Microbiol Immunol  2000; 247:199-210.
  6. Chu RS, Krieg AM, Greenspan NS, Schreiber JR, Harding CV: CpG oligodeoxynucleotides act as adjuvants for polysaccharide-protein conjugate vaccines and selectively enhance anti-polysaccharide IgG2a and IgG3.  Infect and Imm 2000; 68:1450-1456.
  7. Askew D, Chu RS, Krieg AM, Harding CV: CpG DNA induces maturation of dendritic cells with distinct effects on nascent and recycling MHC-II antigen processing mechanisms. J Immunol 2001; 165:6889-6895.
  8. Beck RC, Tubbs RR, Hussein M, Pettay J, Hsi ED: Automated colorimetric in situ hybridization (CISH) detection of immunoglobulin (Ig) light chain mRNA expression in plasma cell (PC) dyscrasias and non-Hodgkin lymphoma. Diag Mol Pathol 2003; 12:14-20.
  9. Beck RC, Stahl S, O’Keefe CL, Maciejewski JP, Theil KS, Hsi, ED: Detection of mature T cell leukemias by flow cytometry using anti-T cell receptor Vbeta antibodies. Am J Clin Pathol 2003; 120:785-94.
  10. Beck RC, Kohn DJ, Tuohy MJ, Prayson RA, Yen-Lieberman B, Procop GW: Detection of polyoma virus in brain tissue of patients with progressive multifocal leukoencephalopathy by real-time PCR and pyrosequencing. Diag Mol Pathol 2004; 13:15-21.
  11. Beck RC, Wlodarski M, Theil KS, Tuthill RJ, Bolwell B, Maciejewski JP: Efficient identification of T-cell clones associated with graft-versus-host disease in target tissue allows for subsequent detection in peripheral blood. Brit J Haematol 2005; 129:411-419.
  12. Procop GW, Beck RC, Pettay JD, Kohn DJ, Tuohy MJ, Yen-Lieberman B, Prayson RA, Tubbs RR. JC virus chromogenic in situ hybridization in brain biopsies from patients with and without PML.  Diagn Mol Pathol 2006; 15:70-3.
  13. Kelley TW, Beck RC, Absi, A, Jin, T, Pohlman, B, Hsi, ED. Biologic predictors in follicular lymphoma: Importance of markers of the immune response.  Leuk Lymphoma 2007; 48:2403-2411.
  14. Beck RC, Padival MP, Yeh D, Ralston J, Cooke KC, and Lowe JB.  The Notch ligands Jagged2, Delta1, and Delta4 induce differentiation and expansion of functional human NK cells from CD34+ cord blood hematopoietic progenitor cells.  Biol Blood Marrow Transplant 2009; 15:1026-103
  15. Beck RC. Production of cytotoxic, KIR-negative NK cells from CD34+ cord blood cells with the use of Notch signaling.  Transfusion 2011;51(SUPPL. 4):145S-152S.
  16. Richardson ET, Shukla S, Nagy N, Boom WH, Beck RC, Zhou L, Landreth GE, Harding CV.  ERK signaling is essential for macrophage development.  PLoS One. 2015 Oct 7;10(10). PMID:26445168
  17. Wang W, Zimmerman G, Huang X, Yu S, Myers J, Wang Y, Moreton S, Nthale J, Awadallah A, Beck R, Xin W, Wald D, Huang AY, Zhou L.  Aberrant Notch signaling in the bone marrow microenvironment of acute lymphoid leukemia suppresses osteoblast-mediated support of hematopoietic niche function. Cancer Res 2016 Mar 15;76(6):1641-52. PMID:26801976
  18. Parameswaran R, Ramakrishnan P, Moreton SA, Xia Z, Hou Y, Lee DA, Gupta K, deLima M, Beck RC, Wald DN. Repression of GSK3 restores NK cell cytotoxicity in AML patients.  Nat Commun 2016 Apr 4;7:11154. PMID:27040177
  19. Tashkandi, H, Meyerson, HJ, and RC Beck.  Circulating atypical T-lymphocytes in a 21-year old female.  Am J Clin Pathol Case Reports 2016.
  20. Vatsayan A, Gupta A, Ahuja S, Egler R, Beck RC, and Matloub Y.  Epstein-Barr Virus-associated mucocutaneous ulcer in a patient with T-cell acute lymphoblastic leukemia: importance of accurate diagnosis and conservative management.  J Pediatr Hematol Oncol  2017 Aug;39(6):e338-e341. PMID: 27879545
  21. Dosani T, Covut F, Beck R, Driscoll JJ, de Lima M, Malek E. Significance of the absolute lymphocyte/monocyte ratio as a prognostic immune biomarker in newly diagnosed multiple myeloma. Blood Cancer J 2017 Jun 30;7(6):e579. doi: 10.1038/bcj.2017.60. PMID: 28665418
  22. Tang F, Schmotzer C, and Beck RC.  A new monoclonal protein detected in a myeloma patient undergoing elotuzumab therapy.  JAMA Oncol 2017, Sep 7,  doi: 10.1001/jamaoncol.2017.2665. PMID: 28880973
  23. Tang F, Malek E, Math S, Schmotzer C, and Beck RC.  Interference of therapeutic monoclonal antibodies with routine serum protein electrophoresis and immunofixation in myeloma patients: frequency and duration of detection of daratumumab and elotuzumab.  Am J Clin Pathol, 2018 Jul 3;150(2):121-129. PMID: 29901687
  24. Van Hedent S, Hokamp N, Laukamp KR, Buls N, Kessner R, Beck R, Ros P, and Jordan D. Differentiation of hemorrhage from iodine using spectral detector CT: A Phantom Study. Am J Neuroradiol 2018 Dec; 39(12):2205-2210. doi: 10.3174/ajnr.A5872. PMID: 30409850
  25. Hamadeh F, Meyerson H, and Beck RC.  Flow cytometry identifies a spectrum of maturation in myeloid neoplasms having plasmacytoid dendritic cell differentiation.  Cytometry B Clin Cytom. 2019 Jan 5. doi: 10.1002/cyto.b.21761. [Epub ahead of print]. PMID: 30614203
  26. Ye R, Driscoll J, Kundrapu S, Beck R, Gerson S, Ali N, Lou G, Landgren O, Van Heeckeren W, Kroeger N, Caimi P, de Lima M, and Malek E.  Immune signatures associated with clonal isotype switch after autologous stem cell transplant for multiple myeloma.  Clin Lymphoma, Myeloma and Leukemia, 2019, Jan 3. pii: S2152-2650(18)31189-3.  PMID: 30878316
  27. Soma L, Kovach AE, Siddon AJ, Beck R, Gibson SE, Swerdlow SH, Kim AS, Wu D, Jones D, Cook JR, Prakash S, Rosado F, Crane G, Bradley K, Weinberg O, and Sargent RL.  Molecular and cytogenetic education in Hematopathology fellowship.  Am J Clin Pathol 2019 May 29. pii: aqz048. doi: 10.1093/ajcp/aqz048. [Epub ahead of print]. PMID: 31141139
  28. Kalisz K, Alessandrino F, Beck R, Smith D, Kikano E, Ramaiya NH, Tirumani SH.  An update on Burkitt lymphoma: a review of pathogenesis and multimodality imaging assessment of disease presentation, treatment response, and recurrence.  Insights Imaging 2019 May 21;10(1):56.  PMID: 31115699
  29. Liput J, Smith DA, Beck R, Ramaiya NH.  Myeloproliferative neoplasms: a primer for radiologists.  J Comput Assist Tomogr 2019 Jul/Aug; 43(4):652-663. PMID: 31268881
  30. Vicioso Y, Gram H, Beck R, Asthana A, Zhang K, Wong D, Letterio J, Parameswaran R.  Combination therapy for treating advanced drug resistant acute lymphoblastic leukemia.  Cancer Immunol Res. 2019 Jul;7(7):1106-1119. doi: 10.1158/2326-6066.CIR-19-0058. Epub 2019 May 28.  PMID: 31138521
  31. Pfau D, Smith DA, Beck R, Gilani KA, Gupta A, Caimi P, and Ramaiya NH. Primary mediastinal large B cell lymphoma: a primer for radiologists.  Am J Radiol, 2019, in press.

Education

Doctor of Medicine
Case Western Reserve University
2001
Doctor of Philosophy
Case Western Reserve University
2001
Bachelor of Arts
Mary Baldwin College
1992

Residencies, Internships and Fellowships

Fellowship in Hematopathology
The Cleveland Clinic Foundation
2005
Residency in Clinical Pathology
The Cleveland Clinic Foundation
2004

Additional Information