Dr. Corey's research and clinical interests in the molecular basis of pediatric cancers began as a pediatric hematology-oncology fellow at Boston Children’s Hospital and in David G. Nathan’s lab with his studies on the newly isolated and produced blood growth factors. Taking a post-doctoral fellowship in Lew Cantley’s lab, Dr. Corey identified the coupling of the Src kinase Lyn with PI 3’kinase in myeloid cells. As a new investigator at the University of Pittsburgh, Dr. Corey focused on G-CSF signaling and used gene targeting as an approach to studying cell signaling. Through this experimental model, he was able to establish the specific contributions of Lyn and PI 3’kinase to G-CSF-induced cell cycle progression and survival. The overriding rationale for his studies is to understand basic biology of inherited bone marrow failure syndromes and myeloid malignancies and translate them into novel therapies.
Department of Molecular Medicine
School of Medicine
Cancer Genomics and Epigenomics Program
Case Comprehensive Cancer Center