Dr. Ming Li is an Associate Professor in the Department of Population and Quantitative Health Sciences and a faculty biostatistician at Center for Proteomics and Bioinformatics at Case Western Reserve University since 2014. Currently, Dr. Li is the Director of Biostatistics and Bioinformatics Shared Resource at Case Comprehensive Cancer Center and serves as a full member of the Case Comprehensive Cancer Center Protocol Review and Monitoring Committee. She is also the Director of Biostatistics Core in the Department of Population and Quantitative Health Sciences.
- Cancer Biostatistics
- Proteomic data analysis
- High dimensional data
- Statistical consulting
Dr. Li’s research interests include proteomics data analysis, cancer biostatistics, statistical and bioinformatics methods for high dimensional data and statistical consulting. With more than 15 years’ experience working in biostatistics field, she has devoted her efforts to two major areas. (1) Collaborative research with principle investigators, during the collaboration, Dr. Li played a key role in multiple aspects, including designing experiments, analyzing data, supervising staff statisticians, interpreting results, drafting manuscripts, and writing statistical sections for grants. (2) High dimensional data analysis, especially methods and software development for proteomics data. Dr. Li is considered a statistician with expertise in proteomics data analysis and has contributed to a significant paper and package on the processing of such data in Bioinformatics and analysis of shotgun proteomics data in Journal of Proteome Research. Recently, she has expanded her collaboration work to construct cophosphorylation networks for phosphor-proteomic data.
- Ayati, M, Wiredja, D, Schlatzer, D, Maxwell, S, Li, M, Koyutürk, M, Chance, MR. CoPhosK: A method for comprehensive kinase substrate annotation using co-phosphorylation analysis. PLoS Comput. Biol. 2019; 15 (2): e1006678. PubMed PMID:30811403 PubMed Central PMC6411229.
- Wiredja, DD, Tabler, CO, Schlatzer, DM, Li, M, Chance, MR, Tilton, JC. Global phosphoproteomics of CCR5-tropic HIV-1 signaling reveals reprogramming of cellular protein production pathways and identifies p70-S6K1 and MK2 as HIV-responsive kinases required for optimal infection of CD4+ T cells.Retrovirology 2018; 15 (1): 44. PubMed PMID:29970186 PubMed Central PMC6029029.
- Kenyon, JD, Sergeeva, O, Somoza, RA, Li, M, Caplan, AI, Khalil, AM, Lee, Z. Analysis of -5p and -3p Strands of miR-145 and miR-140 During Mesenchymal Stem Cell Chondrogenic Differentiation. Tissue Eng Part A 2019; 25 (1-2): 80-90. PubMed PMID:29676203 PubMed Central PMC6352508.
- Yang, LF, Cai, LM, Li, M, Liu, JT, Wang, ZN, Wang, WH, Yang, QT, Chen, ZG. A 10-year retrospective study of alterative aeroallergens sensitization spectrum in urban children with allergic rhinitis. Ther Clin Risk Manag 2018; 14 : 409-416. PubMed PMID:29520147 PubMed Central PMC5834172.
- Karim, AF, Sande, OJ, Tomechko, SE, Ding, X, Li, M, Maxwell, S, Ewing, RM, Harding, CV, Rojas, RE, Chance, MR, Boom, WH. Proteomics and Network Analyses Reveal Inhibition of Akt-mTOR Signaling in CD4+ T Cells by Mycobacterium tuberculosis Mannose-Capped Lipoarabinomannan. Proteomics 2017; 17 (22): . PubMed PMID:28994205 PubMed Central PMC5725663.
- Yu, S, Parameswaran, N, Li, M, Wang, Y, Jackson, MW, Liu, H, Xin, W, Zhou, L. CRABP-II enhances pancreatic cancer cell migration and invasion by stabilizing interleukin 8 expression. Oncotarget 2017; 8 (32): 52432-52444. PubMed PMID:28881741 PubMed Central PMC5581040.
- Wang, W, Yu, S, Myers, J, Wang, Y, Xin, WW, Albakri, M, Xin, AW, Li, M, Huang, AY, Xin, W, Siebel, CW, Lazarus, HM, Zhou, L. Notch2 blockade enhances hematopoietic stem cell mobilization and homing. Haematologica 2017; 102 (10): 1785-1795. PubMed PMID:28729299 PubMed Central PMC5622863.
- Rahman, SMJ, Ji, X, Zimmerman, LJ, Li, M, Harris, BK, Hoeksema, MD, Trenary, IA, Zou, Y, Qian, J, Slebos, RJ, Beane, J, Spira, A, Shyr, Y, Eisenberg, R, Liebler, DC, Young, JD, Massion, PP. The airway epithelium undergoes metabolic reprogramming in individuals at high risk for lung cancer. JCI Insight 2016; 1 (19): e88814. PubMed PMID:27882349 PubMed Central PMC5111517.
- Yang, X, Li, M, Haghiac, M, Catalano, PM, O'Tierney-Ginn, P, Hauguel-de Mouzon, S. Causal relationship between obesity-related traits and TLR4-driven responses at the maternal-fetal interface. Diabetologia 2016; 59 (11): 2459-2466. PubMed PMID:27535280 PubMed Central PMC5583648.
- Hutton, JE, Wang, X, Zimmerman, LJ, Slebos, RJ, Trenary, IA, Young, JD, Li, M, Liebler, DC. Oncogenic KRAS and BRAF Drive Metabolic Reprogramming in Colorectal Cancer. Mol. Cell Proteomics 2016; 15 (9): 2924-38. PubMed PMID:27340238 PubMed Central PMC5013308.