I was recruited to Case Western Reserve University (CWRU) in 2014 as an Assistant Professor (now Associate Professor) in the Department of Population and Quantitative Health Sciences with cross-appointment to the Systems Biology and Bioinformatics Program. I now direct or co-direct the genomics activities of several large cores or consortia, including my own CWRU Applied Functional Genomics Core (AGFC), the Miami Center for AIDS Research (Inter-CFAR) Bioinformatics Network, the CWRU CFAR Experimental and Analytic Systems Biology Core, the international Early Treated Perinatally Infected individuals: Improving Children’s Lives with an HIV Vaccine (EPIICAL) Bioinformatics Platform (Rome, Italy), and the Applied Meta-Omics Core of the Psoriasis Center for Research Translation.
As primarily a team scientist, I work with diverse clinicians and researchers to further build and apply omic workflows, including cancer researchers at CWRU and University Hospitals, the Case Comprehensive Cancer Center, and the Cleveland Clinic. I also conduct traditional grant-based research in applying an amassed interferon versus inflammatory signaling signature database to the further identification of correlates (biomarkers) of protection/pathogenesis in chronic inflammatory illnesses that could be used in specific immunotherapy or vaccine design. My goal coming to CWRU was to build a collaboratory with an international reach designed to harness diverse projects and funding mechanisms in infectious and chronic disease/cancer research.
I established the Applied Functional Genomics Core (AFGC) at CWRU, an independent university-level core that partners closely with the CWRU Genomics Core, to build these collaborations from the ground up and have worked with many cancer investigators at the Center and Cleveland Clinic. The AFGC has processed over 4,700 samples since its inception, however I have eschewed being regarded as a core service and have instead parleyed core engagements into collaborative grants and independent systems projects born from integrating data across very different data types and diseases as evidenced in my >70 peer-reviewed publications in a wide variety of scientific fields. My group has become one of the go-to experts in clinical transcriptomics and analytics on campus, from study design to NGS library generation from difficult clinical samples, to application of highly standardized, report driven, bioinformatic analysis.
Role of interferon signaling genes and the inflammasome in regulating innate and adaptive immune responses.