The Cancer Disparities SPORE consists of two main Research Projects that place an emphasis on colon adenoma, precursor lesion of colorectal cancer (CRC), and on breast cancer, which are the two leading causes of cancer death in the United States and the industrialized world.
Epigenetic Age Acceleration, Neighborhood Disadvantage, and Racial Disparities in Risk of Colon Adenoma
This highly transdisciplinary project investigates the complex interplay of neighborhood contextual factors, personal lifestyle, and colonic tissue epigenetic aging in racial disparities and development of colon neoplasia.
Role of MYC-MIZ1 signaling and the inflammatory immune microenvironment in Triple-Negative Breast Cancer Racial Disparities
This project focuses on testing the hypothesis that racial differences in tumor MYC-MIZ1 signaling and the inflammatory immune microenvironment jointly contribute to triple-negative breast cancer outcome disparities.
Developmental Research Program
Through the support of translational research-focused pilot projects, the Developmental Research Program (DRP) fosters the development of new investigators and new approaches to cancer disparities research. These projects will contribute to improved prevention, early detection, diagnosis, and/or treatment of cancers found to disproportionately affect populations who experience cancer health disparities.
Functional Immune-Phenotypes underlying Racial Disparities in Endometrial Cancer
Awardee: Stefanie Avril, MD
A Stress Biomarker Mediator of a Bridges Out of Poverty CA Control Intervention
Awardee: Heidi Gullett, MD, MPH
Role of Methylation in Prostate Cancer Health Disparity
Exploration of the Relationship between Social and Demographic Factors with Epigenetic Drivers in Race Associated Colon Cancer Disparities
Awardee: Joseph Willis, MD