CanSUR Mentors

Cancer Cell Signaling

Eli Bar, PhD
Assistant Professor, Neurological Surgery
Research Focus: Signal transduction, glioma cell biology, stem-like glioma cells

Susann Brady-Kalnay, PhD
Professor, Molecular Biology and Microbiology
Research Focus: Receptor protein tyrosine phosphatases and cell adhesion, novel imaging agents for glioma

Matthias Buck, PhD
Professor, Physiology and Biophysics
Research Focus: Protein-protein interactions in cell signaling of small GTPases, Plexin and Eph receptors

Fabio Cominelli, MD, PhD
Professor, Gastroenterology
Research Focus: Intestinal inflammation and colitis-associated tumorigenesis

David Danielpour, PhD
Professor, General Medical Sciences-Oncology
Research Focus: Role of TGF-β1 signaling as a mediator androgen-withdrawal induced apoptosis and the mechanism by which AR controls TGF-β signaling

Clark W. Distelhorst, MD
Professor, Hematology and Oncology
Research Focus: Chronic lymphocytic leukemia (CLL); BCl2 blockade

Thomas T. Egelhoff, PhD
Professor, Cellular and Molecular Medicine
Research Focus: Cytoskeleton; wound healing; metastasis; cell migration; breast cancer invasion

Charis Eng, MD, PhD
Professor, Genomic Medicine
Research Focus: Genetics, signaling pathways and mouse modeling of inherited PTEN mutations as they predispose to cancer and autism, leading to gene-enabled risk assessment, genetic counseling and management; microbiome as a modifier of disease

Paul L. Fox, PhD
Professor, Cellular and Molecular Medicine
Research Focus: Angiogenesis; cell migration; endothelial cells; iron metabolism; macrophages; translational control VEGF-Ax as a cancer inhibitor, translation mechanism.

Clifford V. Harding, MD, PhD
Professor, Pathology
Research Focus: Cell biology of antigen presenting cells (APCs) and their regulation by Toll-like receptors

Mark W. Jackson, PhD
Associate Professor, Pathology
Research Focus: Cellular transformation; Tumor microenvironmental cytokines and cancer cell plasticity; JAK/STAT, EGFR, RAS signaling

Ruth A. Keri, PhD
Professor, Pharmacology
Research Focus: genomic and signaling mechanisms that control mammary gland development and cancer

Justin D. Lathia, PhD
Assistant Professor, Cellular and Molecular Medicine
Research Focus: Glioblastoma; role of CSCs in tumorigenesis, cell to cell communication; in vivo imaging

Xiaoxia Li, PhD
Professor, Immunology
Research Focus: IL-1 receptor/Toll-like receptor (IL-1R-TLR) signaling mechanisms

Shigemi Matsuyama, PhD
Associate Professor, Hematology and Oncology
Research Focus: Role of bcl2, Bax and Ku70 in cell survival and cell death

Monica M. Montano, PhD
Associate Professor, Pharmacology
Research Focus: Identification of factors in breast and prostate cancer critical in the transition to hormone-independence, resistance to cancer therapeutics, and ability to metastasize

Agne Petrosiute, MD
Assistant Professor, Hematology and Oncology
Research Focus: Immune checkpoint regulation and tumor immunology

Parameswaran Ramakrishnan, PhD
Assistant Professor, Pathology
Research Focus: Signal transduction in autoimmunity and inflammation as well as immunometabolism

Ofer Reizes, PhD
Assistant Professor, Cellular and Molecular Medicine
Research Focus: Obesity; breast cancer; leptin; cancer stem cell; nanog; cancer stem cells

William P. Schiemann, PhD
Professor, General Medical Sciences-Oncology
Research Focus: "TGFβ Paradox" and its relationship to the initiation of epithelial-mesenchymal transition and cancer stem cell

Nima Sharifi, MD
Associate Professor, Cancer Biology
Research Focus: Steroid metabolism and prostate cancer resistance to hormonal therapies

Robert H. Silverman, PhD
Professor, Cancer Biology
Research Focus: Molecular pathways of the anti-viral and anti-cancer activities of interferon

George R. Stark, PhD
Professor Emeritus, Cancer Biology
Research Focus: Interferons; JAK/STAT signaling; EGFR; NFkB; drug resistance; DNA repair; lung, breast, prostate brain cancer

Vinay Varadan, PhD
Assistant Professor, General Medical Sciences-Oncology
Next-generation sequencing, computational systems biology, functional genomics and genomics-enabled clinical trial development

Bingcheng Wang, PhD
Professor, Nephrology and Hypertension
Research Focus: Eph/ephrin systems in mammalian physiology and tumorigenesis

Aaron Weinberg, DMD, PhD
Professor, Biological Sciences
Research Focus: Fusobacterium in human colon cancer

Jennifer Yu, MD, PhD
Associate Professor, Regional Oncology
Research Focus: Glioblastoma cancer stem cells, DNA repair, radiotherapy.

Youwei Zhang, PhD
Associate Professor, Pharmacology
Research Focus: Chk1, 53BP1 regulation of DSB repair and chromosome stability

Saba Valadkhan, PhD
Assistant Professor, General Medical Sciences-Oncology
Research Focus: Non-coding RNAs in disease, and in metastasis progression

Experimental Therapeutics

Paolo Caimi, MD
Assistant Professor, Hematology and Oncology
Research Focus: Investigator-initiated clinical trials; AML relapse after stem cell transplant; lymphoma

Marcos de Lima, MD
Professor, Hematology and Oncology
Research Focus: Hematopioetic Stem Cell Transplant, NK cell immunotherapy

Chris G. Dealwis, PhD
Associate Professor, Pharmacology
Research Focus: Development of novel ribonucleotide reductase inhibitors.

Stanton L. Gerson, MD
Professor, Hematology and Oncology
Research Focus: Hematopoietic stem cell (HSC) survival, drug resistance and leukemic transformation; targeting DNA repair pathways can enhance the anti-cancer effect of DNA damaging agents; stem cells and DNA repair

Sanjay Gupta, MS, PhD
Professor, Urology
Research Focus: Development of biomarkers for early detection and prognosis of prostate cancer; identification of novel targets to monitor the efficacy of treatment with chemopreventive or therapeutic agents

Chao-Pin Hsiao, PhD, RN
Assistant Professor, Nursing
Research Focus: Molecular-genetic mechanisms of cancer-related fatigue; stress responses, symptoms, symptom distress, and symptom self-management in localized prostate cancer

Alex Huang, MD, PhD
Associate Professor, Hematology and Oncology
Research Focus: Pediatric hematology oncology; tumor immunology and immune-mediated cancer therapy

Vijay Krishna, PhD
Assistant Professor, Molecular Medicine
Research Focus: Nanotechnology-based approaches for cancer treatment and prevention

John Letterio, MD
Professor, Hematology and Oncology
Research Focus: Adolescent and young adult cancers; drug discovery and preclinical development; targeting CDK5 and TGF-beta to alter PD-L1 and PD-1 expression

Jaroslaw Maciejewski, MD, PhD
Professor, Translational Hematology and Oncology Research
Research Focus: Molecular disease mechanisms of bone marrow failure syndromes, including myelodysplastic syndrome (MDS)

Folashade Otegbeye, MD, MPH
Assistant Professor, Hematology and Oncology
Research Focus: Ex-vivo manipulation of donor natural killer cells to produce sufficient therapeutic cell doses and highly activated/cytotoxic cells for infusion

John Pink, PhD
Assistant Professor, General Medical Sciences-Oncology
Research Focus: novel targets for cancer therapy

Reshmi Parameswaran, PhD, MS
Assistant Professor, Pathology
Research Focus: Cell therapy for various hematological malignancies using Natural Killer (NK) cells; development of novel therapeutic trials

Yogen Saunthararajah, MD
Professor, Hematology and Medical Oncology
Research Focus: Molecular targets for p53-independent, non-cytotoxic cancer therapy

David Wald, MD, PhD
Assistant Professor, Pathology
Research Focus: Acute myeloid leukemia (AML), cancer model systems and drug development

Zhenghe (John) Wang, PhD
Professor, Genetics and Genome Sciences
Research Focus: Novel therapeutic approaches to target PIK3CA-mutant colorectal cancers

Cancer Genetics

Nathan Berger, MD
Professor, Hematology and Oncology. Co-Investigator
Research Focus: GI malignancies; obesity and aging-related cancers

J. Mark Brown, PhD
Assistant Professor, Cellular and Molecular Medicine
Research Focus: lipid metabolism; lipoprotein metabolism; microenvironment; high fat diet-induced hepatocellular carcinoma (HCC)

Amitabh Chak, MD
Professor, Gastroenterology
Research Focus: Genetics of Familial Barrett's Esophagus

Jeffery Coller, PhD
Associate Professor, General Medical Sciences
Research Focus: Regulation of mRNA degradation and translation

Stephen Fink, PhD
Assistant Professor, Hematology and Oncology
Research Focus: Colon cancer biomarker discovery; targeting 15-PGDH in colorectal cancer prognosis, prediction, prevention, and treatment

Kishore Guda, DVM, PhD
Assistant Professor, General Medical Sciences-Oncology
Research Focus: Genetic mechanisms underlying colon and esophageal cancer risk

Ahmad Khalil, PhD
Assistant Professor, Genetics and Genome Sciences
Research Focus: Long intergenic non-coding (linc)RNAs as that contribute to cancer initiation, progression and metastasis

Byron Lee, MD, PhD
Assistant Professor, Surgery
Research Focus: urologic malignancies, bladder cancer, epigenetics, chromatin biology, single-cell sequencing, radical cystectomy.

Sanford Markowitz, MD, PhD
Professor, Hematology and Oncology
Research Focus: GI SPORE; Colon cancer genetics; 15-PGDH

Brian P. Rubin, MD, PhD
Professor, Anatomic Pathology
Research Focus: Genetics and biology of sarcomas with particular interest in identification and validation of therapeutic biomarkers and targets

Peter Scacheri, PhD
Associate Professor, Genetics and Genome Sciences
Research Focus: Novel methods for analysis of gene enhancers, predict drug response in colon cancers

Derek Taylor, PhD
Assistant Professor, Pharmacology
Research Focus: Induction of cancer cell death by telomerase-mediated DNA mis-incorporation

Joseph Willis, MD
Professor, Pathology
Research Focus: Genetics of colon carcinogenesis; somatic mutation differences between colon cancers in African Americans and Caucasian Americans

Imaging

James Basilion, PhD
Associate Professor, Radiology
Research Focus: Program Leader Cancer Imaging; Molecular imaging and development of novel imaging probes and paradigms to image cancers non-invasively and in real time

Agata A. Exner, PhD
Professor, Radiology
Research Focus: Deeply penetrable ultrasound contrast agents; molecular detection of prostate specific membrane antigen (PSMA) for detection and biopsy guidance in prostate cancer

Chris A. Flask, PhD
Assistant Professor, Radiology
Research Focus: Development of new preclinical and clinical MRI acquisition and analysis techniques to assess disease mechanisms in vivo; breast, lung, and brain cancer

Mark A. Griswold, PhD
Professor, MRI
Research Focus: Magnetic resonance fingerprinting (MRF); Imaging hardware design and optimization

Zheng-Rong Lu, PhD
Professor, Biomedical Engineering. Research Focus
Research Focus: Design and development of novel contrast agents MRI; imaging tumor microenvironment

Anant Madabhushi, PhD, MS
Professor, Biomedical Engineering
Research Focus: Informatics; developing efficient computational and pattern recognition methods, the existence and correspondence of biological patterns across heterogeneous data such as cancer biopsies.