Pushpa Pandiyan, PhD

Assistant Professor
Biological Sciences
School of Dental Medicine

Research Information

Research Interests

  • Tregs
  • Th17 Cells
  • Candidiasis
  • HIV
  • Candida Infection
  • Inflammation
  • IBD

Research Projects

Optimal immune responses are required to fight infections. However, if the immune responses are not regulated appropriately, they can cause inflammatory disorders. I am studying the mechanisms by which unwanted immune responses are regulated. I am focusing on how regulatory T cells (Tregs) and cytokine networks control inflammatory cells in different disease settings.

Awards and Honors

Performance Award for Special Achievement
2012
National Institute of Allergy and Infectious Diseases
Performance Award for Special Achievement
2011
National Institute of Allergy and Infectious Diseases
Performance Award for Special Achievement
2010
National Institute of Allergy and Infectious Diseases
Post-doctoral Fellow Award
2008
International Cytokine Society
Paper of the Year
2007
National Institutes of Health Cytokine Interest Group
Travel Award
2008
American Association of Immunologists
Invitrogen Trainee Achievement Award
2008
American Association of Immunologists
Travel Grant
2003
National Institutes of Health Keystone Conference
Travel Grant
2003
Humboldt University
PhD Fellowship Grant
2001
Humboldt University

Publications

Pandiyan, P., Gartner, D., Soezeri, O., Radbruch, A., Schulze-Osthoff, K., and Brunner-Weinzierl, M. C.: CD152 (CTLA-4) determines the unequal resistance of Th1 and Th2 cells against activation-induced cell death by a mechanism requiring P13’kinase function. J. Exp. Med. 199: 831-842, 2004.

Pandiyan, P., Hegel, J.K., Krueger, M., Quandt, D., and Brunner-Weinzierl, M.C.: High IFN-gamma production of individual CD8 T lymphocytes is controlled by CD152 (CTLA-4). J. Immunology. 178: 2132-2140, 2007.

Pandiyan, P., Zheng, L., Ishihara, S., Reed, J., and Lenardo, M.: CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation–mediated apoptosis of effector CD4+ T cells. Nature Immunology. 8: 1353-1362, 2007. (RESEARCH HIGHLIGHTS in Science, NEWS & VIEWS in Nature Immunology).

Pandiyan, P., Conti HR, Zheng L, Peterson AC, Mathern DR, Hernández-Santos N, Edgerton M, Gaffen SL and Lenardo MJ. CD4+ CD25+ Foxp3+ regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model. Immunity. 34(3): 422-34. March 2011. (highlighted in RESEARCH HIGHLIGHTS - in Immunity and Nature Review Immunology., Vol 11, 2011).

Pandiyan, P., Yang, X, Saravanamuthu S, Ishihara S, Zheng, L, O’Shea J and Lenardo MJ. The role of IL-15 in activating STAT5 and fine-tuning IL-17A production in CD4 T lymphocytes. J Immunol. 89(9): 4237–4246. 2012.

Education

Postdoctoral Fellowship
National Academy of Sciences
2009
Doctor of Philosophy
Immunology
Humboldt University
Master of Science
Microbiology
Bharathidasan University