- Th17 Cells
- Candida Infection
Optimal immune responses are required to fight infections. However, if the immune responses are not regulated appropriately, they can cause inflammatory disorders. I am studying the mechanisms by which unwanted immune responses are regulated. I am focusing on how regulatory T cells (Tregs) and cytokine networks control inflammatory cells in different disease settings.
Awards and Honors
Pandiyan, P., Gartner, D., Soezeri, O., Radbruch, A., Schulze-Osthoff, K., and Brunner-Weinzierl, M. C.: CD152 (CTLA-4) determines the unequal resistance of Th1 and Th2 cells against activation-induced cell death by a mechanism requiring P13’kinase function. J. Exp. Med. 199: 831-842, 2004.
Pandiyan, P., Hegel, J.K., Krueger, M., Quandt, D., and Brunner-Weinzierl, M.C.: High IFN-gamma production of individual CD8 T lymphocytes is controlled by CD152 (CTLA-4). J. Immunology. 178: 2132-2140, 2007.
Pandiyan, P., Zheng, L., Ishihara, S., Reed, J., and Lenardo, M.: CD4+CD25+ Foxp3+ Tregs cause cytokine deprivation apoptosis of effector CD4 T cells. Nature Immunology. 8: 1353-1362, 2007. (RESEARCH HIGHLIGHTS in Science, NEWS & VIEWS in Nature Immunology).
Pandiyan, P., Conti HR, Zheng L, Peterson AC, Mathern DR, Hernández-Santos N, Edgerton M, Gaffen SL and Lenardo MJ. CD4+ CD25+ Foxp3+ regulatory T cells up-regulate Th17 cytokines in vitro and promote host resistance in mouse Candida albicans Th17 infection model. Immunity. 34: March 2011. (highlighted in RESEARCH HIGHLIGHTS - in Immunity and Nature Review Immunology., Vol 11, 2011).
Pandiyan, P., Yang, X, Saravanamuthu S, Ishihara S, Zheng, L, O’Shea J and Lenardo MJ. The role of IL-15 in activating STAT5 and fine-tuning IL-17A production in CD4 T lymphocytes. In press, Journal of Immunology, 2012.