Fengchun Ye, PhD

Assistant Professor
Biological Sciences
School of Dental Medicine

Research Information

Research Interests

  • Kaposi Sarcoma (KS)
  • KSHV
  • HIV
  • Periodontal Bacteria
  • Angiogenesis 
  • Inflammation
  • Oral Cancer

Research Projects

My research area is pathogenesis of oncogenic viruses such as Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV). I am currently working on how periodontal bacteria enhance viral replication in the oral cavity to promote oral cancer in HIV/AIDS patients. I also work on how KSHV infection promotes angiogenesis, inflammation, and tumor growth.

Professional Memberships

American Society of Microbiology
Center for AIDS Research, CWRU


Fengchun Ye, Lattif AA, Xie J, Weinberg A, and Gao S. Nutlin-3 Induces apoptosis, disrupts viral latency and inhibits expression of angiopoietin-2 in Kaposi sarcoma tumor cells. Cell Cycle. 2012, 11(7): 1393-9.

Greene W, Zhang W, Witt C, Fengchun Ye, and Gao S-J. The ubiquitin/proteasome system mediates entry and endosomal trafficking of Kaposi's sarcoma-associated herpes virus in endothelia cells. PLoS Pathogens, 2012, 8(5): e1002703.

Jones T*, Fengchun Ye1,3*, Bedolla, R *, Huang YF, Meng J, Qian LW, Pan H, Moody R, Wagner B, Arar M, Zhou F, and Gao S-J. Direct and efficient cellular transformation of primary rat mesenchymal precursor cells by KSHV. J. Clin. Investigation. 2012, 122 (3): 1076-81.

Fengchun Ye, Zhou FC, Bedolla R. G, Junes T, Lei XF, Kang T, Guadalupe M, and Gao S-J. Reactive oxygen species hydrogen peroxide mediates Kaposi's sarcoma-associated herpesvirus reactivation from latency. PLoS Pathogens, 2011, 7 (5): e1002054.

Lei XF, Bai ZQ, Fengchun Ye, Xie JP, Kim CG, Huang YF, and Gao S-J. Regulation of NF-κB inhibitor IκBα and viral replication by a KSHV microRNA. Nature Cell Biol, 2010, 12: 193-199.


Doctor of Philosophy
Molecular Microbiology
University of Bordeaux II
Master of Science
Molecular Microbiology
University of Bordeaux
Bachelor of Science
Huazhong Agricultural University