Dr. Barnholtz-Sloan is multi-disciplinary researcher trained in biostatistics, population genetics, and human genetics. Her role in team science has been essential for multiple, successful multi-disciplinary research projects.
She is the PI of the Ohio Brain Tumor Study (OBTS), which has served as a multi-site tissue source site for The Cancer Genome Atlas (TCGA). She is also the scientific PI of the Central Brain Tumor Registry for the United States (CBTRUS). She has extensive experience with multi-site, brain tumor, patient recruitment and bio specimen collection, storage, and clinical annotation. She has multiple roles in the Case Western (CWRU) School of Medicine and the University Hospitals Health System (UHHS), which all focus on optimizing the use of data and analytics to advance health care.
At CWRU, she is the Associate Director for Data Sciences at the Case Comprehensive Cancer Center and the Associate Director for Translational Informatics for the Cleveland Institute of Computational Biology. In these roles, she advances research endeavors by advocating for and assisting researchers in obtaining access to and using large health datasets (publicly available or controlled access) to answer research questions. Dr. Barnholtz-Sloan also aids investigators in the use of secure database infrastructure needed for human subjects’ research, the implementation of robust study designs, as well as the interpretation of results. These efforts aim to reduce the burden and barriers researchers may encounter in gaining access to and analyzing “big data”, enabling them to think about and perform research that has previously not been pursued.
As the Director for Research Health Analytics and Informatics at UHHS, she facilitates access to and analysis of UHHS data. Dr. Barnholtz-Sloan’s efforts focus on aiding clinicians in utilizing “big data” to impact clinical outcomes modeling that can drive both health operations and clinical decision making.
Dr. Barnholtz-Sloan is also Director of the Cleveland Center for Health Outcomes Research (CCHOR), which was established in the summer of 2018. The goal of the CCHOR is to integrate, innovate, and optimize the use of “big data”. CCHOR facilitates access to datasets and helps support analysis to test hypotheses and drive discoveries, facilitating understanding and impact on health.
Together, all of these roles draw upon her extensive experience in hypothesis development, study design and statistical analysis for studies of various phenotypes in humans and animals, and analysis of all types of high throughput “omics” and clinical outcomes data.
Central Brain Tumor Registry of the United States (CBTRUS)
Scientific Principal Investigator https://cbtrus.org
The Central Brain Tumor Registry of the United States (CBTRUS) is a not-for-profit corporation established to provide a resource for descriptive statistical data on all primary brain tumors irrespective of behavior. The CBTRUS database contains the largest aggregation of population-based data on the incidence of all primary brain and central nervous system tumors in the United States. This database has been developed by compiling data from state cancer registries that include information on both malignant and non–malignant primary brain tumors.
Dr. Barnholtz-Sloan with her team works with CBTRUS staff to coordinate data acquisition, develop and manage data sets, and conduct data analyses. She also collaborates on interpreting and disseminating brain and central nervous system tumor data by producing statistical reports and scholarly publications, presentations, responding to data request, and developing grant applications for scientific utilization of the data sets.
Cleveland Institute for Computational Biology (CICB)
Associate Director for Translational Informatics http://www.icompbio.net/
The ICB advances our fundamental knowledge of human biology through the application of computational methods to large and diverse datasets. Further, the CICB promotes the translation of this knowledge into better diagnosis, prognosis, treatment, prevention, and delivery of healthcare. Key elements of our mission include:
- Promoting collaboration through shared resources
- Improving healthcare using electronic health records (EHR)
- Developing new methods to integrate and analyze Big Data
- Supporting educational opportunities in big data and the data sciences.
- Neuro-Oncology, Associate Editor
- Journal of Neuro-Oncology, Associate Editor
- Journal of Clinical Gastroenterology, Associate Editor for Statistics
- Journal of Clinical Oncology Cancer Clinical Informatics, Associate Editor