- Kaposi Sarcoma (KS)
- Periodontal Bacteria
- Oral Cancer
My research area is pathogenesis of oncogenic viruses such as Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV). I am currently working on how periodontal bacteria enhance viral replication in the oral cavity to promote oral cancer in HIV/AIDS patients. I also work on how KSHV infection promotes angiogenesis, inflammation, and tumor growth.
Fengchun Ye, Lattif AA, Xie J, Weinberg A, and Gao S. Nutlin-3 Induces apoptosis, disrupts viral latency and inhibits expression of angiopoietin-2 in Kaposi sarcoma tumor cells. Cell Cycle. 2012, 11(7): 1393-9.
Greene W, Zhang W, Witt C, Fengchun Ye, and Gao S-J. The ubiquitin/proteasome system mediates entry and endosomal trafficking of Kaposi's sarcoma-associated herpes virus in endothelia cells. PLoS Pathogens, 2012, 8(5): e1002703.
Jones T*, Fengchun Ye1,3*, Bedolla, R *, Huang YF, Meng J, Qian LW, Pan H, Moody R, Wagner B, Arar M, Zhou F, and Gao S-J. Direct and efficient cellular transformation of primary rat mesenchymal precursor cells by KSHV. J. Clin. Investigation. 2012, 122 (3): 1076-81.
Fengchun Ye, Zhou FC, Bedolla R. G, Junes T, Lei XF, Kang T, Guadalupe M, and Gao S-J. Reactive oxygen species hydrogen peroxide mediates Kaposi's sarcoma-associated herpesvirus reactivation from latency. PLoS Pathogens, 2011, 7 (5): e1002054.
Lei XF, Bai ZQ, Fengchun Ye, Xie JP, Kim CG, Huang YF, and Gao S-J. Regulation of NF-κB inhibitor IκBα and viral replication by a KSHV microRNA. Nature Cell Biol, 2010, 12: 193-199.