Michael Lederman, MD

Scott R Inkley Professor of Medicine
Department of Medicine
School of Medicine
Department of Pathology
School of Medicine
Department of Molecular Biology and Microbiology
School of Medicine
Department of Bioethics
School of Medicine
Department of Environmental Health Sciences
School of Medicine
Division of Infectious Diseases & HIV Medicine
Center for AIDS Research
School of Medicine
Cancer Prevention
Control & Population Research Program
Case Comprehensive Cancer Center
Principal Investigator
CWRU/UHC AIDS Clinical Trials Unit

Dr. Lederman has served as intern, resident, and chief resident in Medicine and Fellow in Infectious Diseases at Case Western Reserve University, where he joined the faculty in 1980. He is a member of the American Association of Immunologists, the Infectious Diseases Society of America, the HIV Medicine Association and is a councilor of the Clinical Immunology Society. He is also on the editorial boards of AIDS, the Journal of AIDS and Clinical Immunology.

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External Appointments

Associate Director, Center for AIDS Research
University Hospitals Cleveland Medical Center


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Selected Publications

Lederman MM, Veazey R, Hartley O, Mosier D, Dufour J, Mefford M, Piatak M Jr. Salkowitz JR, Rodriguez B, Blauvelt A, Offord R. Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5. Science 306:485-7, 2004.

Salkowitz JR, Sieg SF, Harding CV, Lederman MM. In vitro human memory CD8 T cell expansion in response to cytomegalovirus requires CD4+ T cell help. J Inf Dis 204:971-83, 2004.

Lange CG, Lederman MM, Medvik K, et al. Nadir CD4+ T-cell count and numbers of CD28+ CD4+ T-cells predict functional responses to immunizations in chronic HIV-1 infection. Aids. Sep 26 2003;17(14):2015-2023.

Quinones-Mateu ME, Lederman MM, Feng Z, et al. Human epithelial beta-defensins 2 and 3 inhibit HIV-1 replication. Aids. Nov 7 2003;17(16):F39-48.

Sieg SF, Bazdar DA, Lederman MM. Impaired TCR-mediated induction of Ki67 by naive CD4+ T cells is only occasionally corrected by exogenous IL-2 in HIV-1 infection. J Immunol. Nov 15 2003;171(10):5208-5214.

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