ISSACS is a member of CESMII, the Smart Manufacturing Institute, a US government funded, non-profit organization to drive Smart Manufacturing.

CESMII's mission is to "radically accelerate the development and adoption of advanced sensors, controls, platforms, and models, to enable Smart Manufacturing (SM) to become the driving sustainable engine that delivers real-time business improvements in U.S. manufacturing."

In recognition of CWRU's strong expertise in Smart Manufacturing combined with outstanding location industry partnerships, the US Department of Energy and CESMII selected ISSACS to lead a Smart Manufacturing Innovation Center (SMIC) in Cleveland.