Research in the Tolbert Group endeavors to understand the molecular mechanisms RNA viruses use to express their genomes. Nuclear magnetic resonance (NMR) spectroscopy and other solution biophysical methods are used to determine 3D structures and physiochemical properties of viral RNA regulatory elements both free and bound to their cognate host proteins. Their primary focus has been to understand how the HIV regulates RNA processing events, with other projects including the molecular mechanisms of Enterovirus 71 (EV71), the etiological agent of Hand, Foot, and Mouth Disease. This year, Tolbert has turned his virtuosity toward the SARS-2 coronavirus and will explain what his work here means for understanding the virus.
Friends of the Institute for the Science of Origins & Emeritus Faculty are eligible for the member rate for this program.