Estimation of excitatory and inhibitory input rate from a single voltage trace

Ryota Kobayashi

For better understanding the computational mechanism in neural circuits, it is
essential to determine excitatory and inhibitory synaptic inputs to a neuron
in vivo.  It is necessary to develop a method for estimating the synaptic
inputs based on experimental data, because their direct measurement is beyond
the current technology.  Here, we have developed a method for estimating the
synaptic input rates from a single voltage trace based on the
Ornstein-Uhlenbeck model.  Next, the proposed method is extended for more
realistic models, i.e., Hodgkin-Huxley type models.  It is demonstrated that
the method can estimate not only the synaptic input but also the ion channel
state from a voltage trace.  This work is joint work with Petr Lansky, Shigeru
Shinomoto, and Yasuhiro Tsubo.