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Donald D. Anthony, M.D., Ph.D.

Associate Professor of Medicine, Case Western Reserve University

Division of Rheumatology & Division of Infectious Diseases & HIV Medicine

Email : dda3@case.edu
Office Phone : 216.368.3540


  • B.S. : Biochemistry, Case Western Reserve University, 1982-1986
  • M.D./ Ph.D. : Case Western Reserve University, 1986-1993
  • Internship & Residency : Internal Medicine, University Hospitals of Cleveland, 1993-1996
  • Fellowship : Rheumatology, University Hospitals of Cleveland, 1996-1999

Clinical Interests

  • Extrahepatic manifestations of chronic HCV infection.
  • Autoimmune disease.

Research Interests

Dr. Anthony's primary research interests are in : 1) mechanisms of Immune Activation during chronic HCV and HIV infection; 2) dendritic cell-NK cell interactions in the settings of HCV and HIV infections as they relate to disease stage and response to therapy; 3) immune predictors of response to HBV vaccine in the setting of HCV and HIV infection; 4) development of newer methods to evaluate human dendritic cells in the context of disease; and 5) mechanisms of B cell activation underlying HCV associated cryoglobulinemic vasculitis.

Selected References

  • Sugalski JM, Rodriguez B, Moir S, and Anthony DD (2010). Peripheral blood B cell subset skewing is associated with altered cell cycling, intrinsic resistance to apoptosis and reflects a state of immune activation in chronic HCV infection. J Immunol, 185, 3019-3027 PMID: 20656924.
  • Yonkers NL, Sieg S, Rodriguez B, Anthony DD (2011). Reduced naïve CD4 T-cell numbers and impaired induction of CD27 in response to TCR stimulation reflect a state of immune activation in chronic HCV infection. J Infect Dis. 203, 635-645 PMID: 21220773.
  • Canaday DH, Burant CJ, Jones L, Aung H, Woc-Colburn L, Anthony DD (2011). Preserved MHC-II antigen processing and presentation function in chronic HCV infection. Cellular Immunol (266, 187–191 PMID: 21055734).
  • Anthony DD, Umbleja T, Aberg JA, Kang M, Medvik K, Lederman MM, Peters MG, Koziel MJ and Overton ET. (2011) Lower peripheral blood CD14+ monocyte frequency and higher CD34+ progenitor cell frequency are associated with HBV vaccine induced response in HIV infected individuals. Vaccine (29, 3558-3563).
  • Anthony DD, Conry SJ, Medvik K, Sandhya Rani MR, Falck-Ytter Y, Blanton RE, Lederman MM, Rodriguez B, Landay AL, Sandberg JK (2012) Baseline levels of soluble CD14 and CD16+56- NK cells are negatively associated with response to IFN/Ribavirin therapy during HCV-HIV-1 co-infection. J Infect Dis. doi: 10.1093/infdis/jis434.
  • Schlatzer DM, Sugalski JM, Chen Y, Barnholtz-Sloan J, Davitkov P, Hazlett FE, Funderburg N, Rodriguez B, Lederman MM, Sieg SS, Chance MR, Anthony DD (2013). Plasma proteome reflects overlapping, yet distinct mechanisms of immune activation comparing chronic HCV and HIV infection. J AIDS (63, 563-571) NIHMS465038, PMC3762939
  • Meng Q, Sandhya Rani MR, Judge CJ, Phat S, Rodriguez B, Blanton RE, Anthony DD (2014) During chronic HCV infection NCR dependent NK cytolytic activity directed at HCV is associated with liver inflammation, African American Race, IL28B genotype and response to PegIFN/RBV therapy(J. Infectious Dis, May 15;209(10):1591-601. doi: 10.1093/infdis/jit677. PMID: 24302757