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David H. Canaday, M.D.

Associate Professor of Medicine, Case Western Reserve University

Associate Director, Geriatric, Research, Education and Clinical Center
 (GRECC), Louis Stokes Cleveland VA Medical Center

Division of Infectious Diseases & HIV Medicine,
 University Hospitals Cleveland Medical Center


Email : dxc44@case.edu
Office Phone : 216.368.8901
Lab Phone : 216.368.0344
Fax : 216.368.2034

Education

  • B.A : University of Pennsylvania , 1984-1988
  • M.D. : Washington University School of Medicine, 1988-1992
  • Residency : Internal Medicine, University of Minnesota, 1992-1995
  • Fellowship, Infectious Diseases, University Hospitals of Cleveland, 1995-1999

Research Interests

The main focus of the lab is understanding changes in the human immune system that occur with aging. Primarily we do this through study of vaccine responses in older individuals with a focus on influenza and shingles vaccines. 

A second interest of the lab is understanding the mechanisms of increased pathogenesis during HIV/TB co-infection.

Selected References

  • Canaday DH, Ziebold C, Noss E, Chervenak KA, Harding CV, Boom WH. Activation of human CD8+ ab+ TCR+ T cells by M. tuberculosis via an alternate class I MHC antigen processing pathway. Journal of Immunology. 162:372-9, 1999.  PMID: 9886409
  • Canaday DH, Wilkinson RJ , Li Q, Clifford V Harding CV, Silver RF, WH Boom. CD4+ and CD8+ T cells kill intracellular M. tuberculosis by a perforin and FAS/FASL independent mechanism.  Journal of Immunology.  167:2734-2742, 2001.  PMID: 11509617
  • Canaday DH, Beigi R, Silver RF, Harding CV, Boom WH, Dubyak GR.  ATP and Control of Intracellular Growth of Mycobacteria by T Cells.  Infection and Immunity.  70: 6456-6459, 2002.  PMCID: PMC130300
  • Canaday DH, Gehring A, Leonard EG, Eilertson B, Schreiber JR, Harding CV, Boom WH. T cell hybridomas from HLA-transgenic mice as tools for analysis of human antigen processing. Journal of Immunological Methods.  281: 129-142, 2003. PMID: 14580887
  • Tobian AR, Harding CV*, Canaday DH*.   Mycobacterium tuberculosis heat shock protein enhances class I MHC cross processing and presentation by B lymphocytes.  Journal of Immunology. 174: 5209-5214. 2005.  PMID: 15843516
  • Jones LJ, McDonald DM, Canaday DH.  Rapid MHC-II antigen presentation of HIV-1 by dendritic cells.  AIDS research and Human Retroviruses. AIDS Research and Human Retroviruses. 23:812-6. 2007.  PMID: 17604545
  • Woc-Colburn L, Smultea L, Ramachandra L, Canaday DH. Preserved MHC class II antigen processing in monocytes from HIV-infected individuals. PLoS One. 2010 Mar 3;5(3):e9491. PMCID: PMC2831061
  • Canaday DH, Amponsah NA, Jones L, Tisch DJ. Hornick TR, Ramachandra L. Influenza-induced production of interferon-alpha is defective in geriatric individuals.  Journal Clinical Immunology. 2010. May;30(3):373-83. PMCID: PMC2875067
  • Reuter M, Canaday DH, McDonald D. Mycobacterium tuberculosis promotes HIV trans-infection and suppresses antigen processing by dendritic cells. Journal of Virology, 84:8549-60. 2010.  PMCID: PMC2919047
  • Canaday DH, Burant C, Jones L, Aung H, Woc-Colburn L, Anthony DD.  Antigen processing and presentation preserved in myeloid dendritic cells and monocytes from HCV-infected individuals.  Cellular Immunology. 266:187-91. 2011. PMCID: PMC3005840
  • El Fenniri L, Toossi Z, Aung H, El Iraki G, Bourkkadi J, Benamor J, Laskri A, Berrada N,  Benjouad A, Mayanja-Kizza H, Betts MR, El Aouad R, Canaday DH*.  Polyfunctional M. tuberculosis-specific effector memory CD4+ T cells at sites of pleural TB.  Tuberculosis. 91:224-30. 2011. PMCID: PMC3306579
  • Clark HL, Banks, R, Jones L, Hornick TR, Higgins PA, Burant C, Canaday DH. Characterization of MHC-II antigen presentation by B cells and monocytes from older individuals. Clinical Immunology. 2012 Aug;144(2):172-7. PMCID: PMC3466105
  • Herati RS, Reuter MA, Dolfi DV, Mansfield KD, Aung H, Badwan OZ, Kurupati RK, Kannan S, Ertl H, Schmader KE, Betts MR, Canaday DH*, Wherry EJ. Circulating CXCR5+PD-1+ response predicts influenza vaccine antibody responses in young adults but not elderly adults. Journal of Immunology, 2014, Oct 1;193(7):3528-3. PMCID: PMC4170011
  • Van Epps P, Banks R, Aung H, Betts MR, Canaday DH. Age-related differences in polyfunctional T cell Responses. Immunity & Ageing. 2014 Oct 23;11:14. doi: 10.1186/1742-4933-11-14. eCollection 2014.  PMID: 25512758
  • Canaday DH, Sridaran S, Van Epps P, Aung H, Burant CJ, Nserko M, Mayanja-Kizza H, Betts MR, Toossi Z.  CD4+ T cell polyfunctional profile in HIV-TB coinfection are similar between individuals with latent and active TB infection. Tuberculosis. 2015 Jul;95(4):470-5. PMID:25956974
  • Van Epps P, Sridaran S, Aung H, Wilson B,  Burant CJ, Nsereko M, Mayanja-Kizza H, Betts MR, Toossi Z, Canaday DH. CD4 T cell cytokine correlates of diagnostic tests for latent TB in HIV-1-infected subjects. International Journal of Tuberculosis and Lung Disease. 19:927-935. 2015.  PMID: 26162359
  • Younes SA, Freeman ML, Mudd JC, Shive CL, Reynaldi A, Panigrahi S, Estes JD, Deleage C, Lucero C, Anderson J, Schacker TW, Davenport MP, McCune JM, Hunt PW, Lee SA, Serrano-Villar S, Debernardo RL, Jacobson JM, Canaday DH, Sekaly RP, Rodriguez B, Sieg SF, Lederman MM.  IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection. Journal of Clinical Investigation. 2016 Jul 1;126(7):2745-56. PMID:  27322062
  • Van Epps P, Oswald D, Higgins PA, Hornick TR, Aung H, Banks RE, Wilson BM, Burant C, Gravenstein S, Canaday DH.  Frailty has a stronger association with inflammation than age in older veterans. Immunity & Ageing 2016, 13 :27 (19 October 2016).  PMID: 27777599
  • Van Epps P, Tumpey T, Pearce MB, Golding HH, Higgins P, Hornick T,  Burant C, Wilson BW, Banks R, Gravenstein S, Canaday DH.  Preexisting Immunity Not Frailty Phenotype Predicts Influenza Post Vaccination Titers Among Older Veterans. Clinical and Vaccine Immunology, 2017 Mar 6;24(3). pii: e00498-16. doi: 10.1128/CVI.00498-16. Print 2017 Mar. PMID: 28100496
  • Knox JJ, Buggert M, Kardava L, Seaton KE, Eller MA, Canaday DH, Robb ML, Ostrowski MA, Deeks SG, Slifka MK, Tomaras GD, Moir S, Moody MA, Betts MR.  T-bet+ B cells are induced by human viral infections and dominate the HIV gp140 response.  JCI Insight. 2017 Apr 20;2(8). pii: 92943. doi: 10.1172/jci.insight.92943. PMID: 28422752
  • Reuter MA. Del Rio Estrada PM, Buggert M, Ferrando-Martinez S, Son Nguyen S, Alberto Sada Japp AS, Ablanedo-Terrazas Y, Rivero-Arrieta A, Kuri-Cervantes L, Gunzelman HM, Gostick E, Price DA, Koup RA, Naji A, Canaday DH, Reyes-Tera G, Betts MR. HIV-Specific CD8 T Cells Exhibit Reduced and Differentially Regulated Cytolytic Activity in Lymphoid Tissue. Cell Reports. 2017 Dec 19;21(12):3458-3470. doi: 10.1016/j.celrep.2017.11.075. PMID: 29262326
  • Nipper AJ, Smithey MJ, Shah RC, Canaday DH, Landay AL. Diminished antibody response to influenza vaccination is characterized by expansion of an age-associated B-cell population with low PAX5.  Clinical Immunology. 2018 Feb 6. pii: S1521-6616(17)30813-6. PMID: 29425852
  • Buggert M, Nguyen S, McLane LM, Steblyanko M, Anikeeva N, Paquin-Proulx D, Del Rio Estrada PM, Ablanedo-Terrazas Y, Noyan K, Reuter MA, Demers K, Sandberg J, Eller MA, Streeck H, Jansson M, Nowak P, Sönnerborg A, Canaday DH, Naji A, Wherry EJ, Robb M, Deeks SG, Reyes-Teran G, Sykulev Y, Karlsson AC, Betts MR.  Limited immune surveillance in lymphoid tissue by cytolytic CD4+ T cells during health and HIV disease. PLoS Pathogens. 2018 Apr 13;14(4):e1006973. doi: 10.1371/journal.ppat.1006973. PMID: 29652923
  • Sayin I, Radtke AR, Vella LA, Jin W, Wherry EJ, Buggert M, Betts MR, Herati RS, Germain RN, Canaday DH. Spatial distribution and function of T follicular regulatory cells in human lymph nodes. Journal of Experimental Medicine. 2018 May 16. pii: jem.20171940. doi: 10.1084/jem.20171940. PMID: 29769249. Cover Photo and paper both.
  • Buggert M, Nguyen S, Salgado-Montes de Oca G, Bengsch B, Darko S, Ransier A, Roberts ER, Del Alcazar D, Brody IB, Vella LA, Beura L, Wijeyesinghe S, Herati RS, Del Rio Estrada PM, Ablanedo-Terrazas Y, Kuri-Cervantes L, Sada Japp A, Manne S, Vartanian S, Huffman A, Sandberg JK, Gostick E, Nadolski G, Silvestri G, Canaday DH, Price DA, Petrovas C, Su LF, Vahedi G, Dori Y, Frank I, Itkin MG, Wherry EJ, Deeks SG, Naji A, Reyes-Terán G, Masopust D, Douek DC, Betts MR.  Identification and characterization of HIV-specific resident memory CD8+ T cells in human lymphoid tissue.  Science Immunology. 2018 Jun 1;3(24). PMID: 29858286
  • Sahmoudi K, Hasan Abbassi H, Bouklata N, El Alami MN, Sadak A, Burant C, Boom WH, El Aouad R, David H. Canaday DH*, Seghrouchni F*. Immune Activation and Regulatory T Cells in Mycobacterium tuberculosis Infected Lymph Nodes. BMC Immunology. 2018 Nov 8;19(1):33. PMID: 30409122
  • * shared senior author