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Michael M. Lederman, M.D.

Scott R. Inkley Professor of Medicine

Co-Director, Center for AIDS Research

Principal Investigator, AIDS Clinical Trials Unit

Email : mxl6@case.edu
Office Phone : 216.844.8786
Fax : 216.844.5523
Outpatient Clinic : Special Immunology Unit


  • B.A. : Biology, Brandeis University, 1966-1970
  • M.D. : Mount Sinai School of Medicine, 1970-1974
  • Intern : Internal Medicine, University Hospitals of Cleveland, 1974-1975
  • Junior Assistant Resident: Internal Medicine, Mount Sinai Hospital, 1975-1976
  • Resident : Internal Medicine, University Hospitals of Cleveland, 1976-1977
  • Chief Resident : Internal Medicine, Louis Stokes Cleveland VA Medical Center, 1977-1978
  • Fellowship, Infectious Diseases, University Hospitals of Cleveland, 1978-1980

Research Interests

Mechanisms of immune deficiency and enhancing immune function in HIV-1 infection.

Dr. Lederman has served as intern, resident, chief resident in Medicine and fellow in Infectious Diseases at Case Western Reserve University where he joined the faculty in 1980. He is a member of the American Association of Immunologists, the Infectious Diseases Society of America, the HIV Medicine Association and is a councilor of the Clinical Immunology Society. He is on the editorial boards of AIDS, the Journal of AIDS and Clinical Immunology.

Selected References

  • Imamichi H, DeGray G, Asmuth DM, Fischl MA, Landay AL, Lederman MM, Sereti I. HIV-1 quasispecies detected during transient HIV viremia following IL-7 administration are similar to the viral quasispecies present before and after IL-7 therapy. AIDS 2011 Jan 14;25(2):159-64.
  • Pilch-Cooper HA, Sieg SF, Hope TJ, Koons A, Offord R, Veazey RS, Mosier DE, Clagett B, Medvik K, Jadlowski JK, Chance MR, Kiselar JG, Hoxie JA, Collman RG, Riddick NE, Hartley O, Lederman MM. Circulating human CD4 and CD8 T cells do not have large intracellular pools of CCR5. Blood 2011 Jul 28;118(4):1015-9. Epub 2010 Nov 10.
  • Crane HM, Grunfeld C, Willig J, Mugavero MJ, Van Rompaey S, Moore R, Rodriguez B, Lederman MM, Kitahata MM. Impact of nucleoside reverse transcriptase inhibitors on changes in lipid levels among a large HIV-infected cohort initiating antiretroviral therapy in routine clinical care settings across the United States. AIDS 2011 Jan 14;25(2):185-95.
  • Li JZ, Brumme ZL, Brumme C, Wang H, Spritzler J, Robertson M, Lederman MM, Carrington M, Walker BD, Schooley RT, Kuritzkes DR. Factors Associated with Viral Rebound in HIV-Infected Individuals Enrolled in a Therapeutic HIV-1 gag Vaccine Trial. J. Infect Dis 2011 Apr;203(7):976-983.
  • Jiang W, Lederman MM, Harding CV, Sieg SF. Presentation of soluble antigens to CD8+ T cells by CpG ODN-primed na├»ve B cells. J Immunol 2011 Feb 15;186(4):2080-6.
  • Anthony DD, Umbleja T, Aberg JA, Kang M, Medvik K, Lederman MM, Peters MG, Koziel MJ and Overton ET. Lower peripheral blood CD14+ monocyte frequency and higher CD34+ progenitor cell frequency are associated with HBV vaccine induced response in HIV infected individuals. Vaccine 2011 Apr 27;29(19):3558-63. Epub 2011 Mar 11.