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Federico Perez, M.D.

Assistant Professor of Medicine, Case Western Reserve University

Director, Fellowship Program,

  Division of Infectious Diseases & HIV Medicine

Infectious Diseases, Louis Stokes Cleveland VA Medical Center

Email : federico.perez@va.gov
Office Phone : 216.791.3800
Fax : 216.229.2403
Office : louis Stokes Cleveland VA Medical Center


  • M.D., Universidad del Valle School of Medicine, Cali, Colombia, 2001
  • Internal Medicine Residency, University Hospitals Cleveland Medical Center, 2006
  • Infectious Diseases Fellowship, University Hospitals Cleveland Medical Center, 2009

Research Interests

Molecular epidemiology, clinical impact and transmission dynamics of multidrug resistant Gram-negative bacteria

Selected References

  • Perez F, Hujer AM, Hujer KM, Decker BK, Rather PN, et al. Global challenge of multidrug-resistant Acinetobacter baumannii. Antimicrob Agents Chemother. 2007 Oct;51(10):3471-84. PubMed PMID: 17646423; PubMed Central PMCID: PMC2043292.
  • Perez F, Endimiani A, Hujer KM, Bonomo RA. The continuing challenge of ESBLs. Curr Opin Pharmacol. 2007 Oct;7(5):459-69. PubMed PMID: 17875405; PubMed Central PMCID: PMC2235939.
  • Perez F, Salata RA, Bonomo RA. Current and novel antibiotics against resistant Gram-positive bacteria. Infect Drug Resist. 2008;1:27-44. PubMed PMID: 21694878; PubMed Central PMCID: PMC3108725.
  • Perez F, Endimiani A, Bonomo RA. Why are we afraid of Acinetobacter baumannii?. Expert Rev Anti Infect Ther. 2008 Jun;6(3):269-71. PubMed PMID: 18588489; PubMed Central PMCID: PMC4085750.
  • Perez F, Hujer AM, Hulten EA, Fishbain J, Hujer KM, et al. Antibiotic resistance determinants in Acinetobacter spp and clinical outcomes in patients from a major military treatment facility. Am J Infect Control. 2010 Feb;38(1):63-5. PubMed PMID: 19783325; PubMed Central PMCID: PMC4085753.
  • Perez F, Endimiani A, Ray AJ, Decker BK, Wallace CJ, et al. Carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae across a hospital system: impact of post-acute care facilities on dissemination. J Antimicrob Chemother. 2010 Aug;65(8):1807-18. PubMed PMID: 20513702; PubMed Central PMCID: PMC2904665.
  • Perez F, Ponce-Terashima R, Adams MD, Bonomo RA. Are we closing in on an "elusive enemy"? The current status of our battle with Acinetobacter baumannii. Virulence. 2011 Mar-Apr;2(2):86-90. PubMed PMID: 21499025.
  • Perez F, Pultz MJ, Endimiani A, Bonomo RA, Donskey CJ. Effect of antibiotic treatment on establishment and elimination of intestinal colonization by KPC-producing Klebsiella pneumoniae in mice. Antimicrob Agents Chemother. 2011 Jun;55(6):2585-9. PubMed PMID: 21422202; PubMed Central PMCID: PMC3101444.
  • Decker BK, Perez F, Hujer AM, Hujer KM, Hall GS, et al. Longitudinal analysis of the temporal evolution of Acinetobacter baumannii strains in Ohio, USA, by using rapid automated typing methods. PLoS One. 2012;7(4):e33443. PubMed PMID: 22511922; PubMed Central PMCID: PMC3325217.
  • Perez F, Bonomo RA. Can we really use ß-lactam/ß-lactam inhibitor combinations for the treatment of infections caused by extended-spectrum ß-lactamase-producing bacteria?. Clin Infect Dis. 2012 Jan 15;54(2):175-7. PubMed PMID: 22057699.
  • Perez F, Van Duin D. Carbapenem-resistant Enterobacteriaceae: a menace to our most vulnerable patients. Cleve Clin J Med. 2013 Apr;80(4):225-33. PubMed PMID: 23547093; PubMed Central PMCID: PMC3960994.
  • Perez F, Rudin SD, Marshall SH, Coakley P, Chen L, et al. OqxAB, a quinolone and olaquindox efflux pump, is widely distributed among multidrug-resistant Klebsiella pneumoniae isolates of human origin. Antimicrob Agents Chemother. 2013 Sep;57(9):4602-3. PubMed PMID: 23817374; PubMed Central PMCID: PMC3754307.
  • Wright MS, Haft DH, Harkins DM, Perez F, Hujer KM, et al. New insights into dissemination and variation of the health care-associated pathogen Acinetobacter baumannii from genomic analysis. MBio. 2014 Jan 21;5(1):e00963-13. PubMed PMID: 24449752; PubMed Central PMCID: PMC3903280.
  • Perez F, Deshpande A, Kundrapu S, Hujer AM, Bonomo RA, et al. Pseudo-outbreak of Klebsiella oxytoca spontaneous bacterial peritonitis attributed to contamination of multidose vials of culture medium supplement. Infect Control Hosp Epidemiol. 2014 Feb;35(2):139-43. PubMed PMID: 24442075; PubMed Central PMCID: PMC3957413.
  • Perez F, Bonomo RA. Vaccines for Acinetobacter baumannii: thinking "out of the box". Vaccine. 2014 May 7;32(22):2537-9. PubMed PMID: 24662709; PubMed Central PMCID: PMC4028134.
  • van Duin D, Perez F, Rudin SD, Cober E, Hanrahan J, et al. Surveillance of carbapenem-resistant Klebsiella pneumoniae: tracking molecular epidemiology and outcomes through a regional network. Antimicrob Agents Chemother. 2014 Jul;58(7):4035-41. PubMed PMID: 24798270; PubMed Central PMCID: PMC4068524.
  • Wright MS, Perez F, Brinkac L, Jacobs MR, Kaye K, et al. Population structure of KPC-producing Klebsiella pneumoniae isolates from midwestern U.S. hospitals. Antimicrob Agents Chemother. 2014 Aug;58(8):4961-5. PubMed PMID: 24913165; PubMed Central PMCID: PMC4136011.
  • Perez F, Hujer AM, Marshall SH, Ray AJ, Rather PN, et al. Extensively drug-resistant pseudomonas aeruginosa isolates containing blaVIM-2 and elements of Salmonella genomic island 2: a new genetic resistance determinant in Northeast Ohio. Antimicrob Agents Chemother. 2014 Oct;58(10):5929-35. PubMed PMID: 25070102; PubMed Central PMCID: PMC4187935.
  • Perez F, Adachi J, Bonomo RA. Antibiotic-resistant gram-negative bacterial infections in patients with cancer. Clin Infect Dis. 2014 Nov 15;59 Suppl 5:S335-9. PubMed PMID: 25352627; PubMed Central PMCID: PMC4303050.
  • Perez F, Bonomo RA. Bloodstream Infection Caused by Extended-Spectrum β-Lactamase-Producing Gram-Negative Bacteria: How to Define the Best Treatment Regimen?. Clin Infect Dis. 2015 Jan 13;PubMed PMID: 25586684.