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Benigno Rodriguez, M.D.

Associate Professor of Medicine, Case Western Reserve University

Division of Infectious Diseases & HIV Medicine

Email : rodriguez.benigno@clevelandactu.org
Office Phone : 216.844.2057
Fax : 216.844.5523
Appointments : 216.844.7890


  • M.D. : Javeriana University School of Medicine, Bogata, Columbia, 1990
  • Residency : Internal Medicine, San Ignacio University Hospital, Bogata, Columbia 1995
  • M.S. : Tropical & Parasitic Diseases, University of Valencia, Valencia , Spain, 1996
  • Fellowship, Infectious Diseases, University Hospitals of Cleveland, 2000-2004

Clinical Interests


Research Interests


Selected References

  • Conry SJ, Meng Q, Hardy G, Yonkers NL, Sugalski JM, Hirsch A, Davitkov P, Compan A, Falck-Ytter Y, Blanton RE, Rodriguez B, Harding CV, Anthony DD; Genetically Associated CD16+56- Natural Killer Cell Interferon (IFN)-αR Expression Regulates Signaling and Is Implicated in IFN-α-Induced Hepatitis C Virus Decline. J Infect Dis. 2012 Apr;205(7):1131-41. Epub 2012 Feb 20.
  • Manion M, Rodriguez B, Medvik K, Hardy G, Harding CV, Schooley RT, Pollard R, Asmuth D, Murphy R, Barker E, Brady KE, Landay A, Funderburg N, Sieg SF, Lederman MM. Interferon-alpha administration enhances CD8+ T cell activation in HIV infection. PLoS One. 2012;7(1):e30306. Epub 2012 Jan 24.
  • Silverberg MJ, Lau B, Justice AC, Engels E, Gill MJ, Goedert JJ, Kirk GD, D'Souza G, Bosch RJ, Brooks JT, Napravnik S, Hessol NA, Jacobson LP, Kitahata MM, Klein MB, Moore RD, Rodriguez B, Rourke SB, Saag MS, Sterling TR, Gebo KA, Press N, Martin JN, Dubrow R; the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of IeDEA. Risk of Anal Cancer in HIV-Infected and HIV-Uninfected Individuals in North America. Clin Infect Dis. 2012 Feb 13. [Epub ahead of print]
  • Mayne E, Funderburg NT, Sieg SF, Asaad R, Kalinowska M, Rodriguez B, Schmaier AH, Stevens W, Lederman MM. Increased platelet and microparticle activation in HIV infection: upregulation of P-selectin and tissue factor expression. J Acquir Immune Defic Syndr. 2011 Dec 9.
  • Affandi JS, Aghafar ZK, Rodriguez B, Lederman MM, Burrows S, Senitzer D, Price P. Can immune-related genotypes illuminate the immunopathogenesis of cytomegalovirus disease in human immunodeficiency virus-infected patients? Hum Immunol. 2012 Feb;73(2):168-74. Epub
  • Bark CM, Traboulsi RS, Honda K, Starnes AM, Jacobs MR, Rodriguez B. Disseminated Mycobacterium chelonae infection in a patient receiving an epidermal growth factor receptor inhibitor for advanced head and neck cancer. J Clin Microbiol. 2012 Jan;50(1):194-5. Epub 2011 Oct 26.
  • Lederman MM, Calabrese L, Funderburg NT, Clagett B, Medvik K, Bonilla H, Gripshover B, Salata RA, Taege A, Lisgaris M, McComsey GA, Kirchner E, Baum J, Shive C, Asaad R, Kalayjian RC, Sieg SF, Rodriguez B. Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells. J Infect Dis. 2011 Oct 15;204(8):1217-26.
  • Poon AF, Aldous JL, Mathews WC, Kitahata M, Kahn JS, Saag MS, Rodríguez B, Boswell SL, Frost SD, Haubrich RH. Transmitted drug resistance in the CFAR network of integrated clinical systems cohort: prevalence and effects on pre-therapy CD4 and viral load. PLoS One. 2011;6(6):e21189. Epub 2011 Jun 20.
  • Mehlotra RK, Cheruvu VK, Blood Zikursh MJ, Benish RL, Lederman MM, Salata RA, Gripshover B, McComsey GA, Lisgaris MV, Fulton S, Subauste CS, Jurevic RJ, Guillemette C, Zimmerman PA, Rodriguez B. Chemokine (C-C motif) receptor 5 -2459 genotype in patients receiving highly active antiretroviral therapy: race-specific influence on virologic success. J Infect Dis. 2011 Jul 15;204(2):291-8. PMID: 21673041
  • Rodriguez B, Bazdar DA, Funderburg N, Asaad R, Luciano AA, Yadavalli G, Kalayjian RC, Lederman MM, Sieg SF. Frequencies of FoxP3+ naive T cells are related to both viral load and naive T cell proliferation responses in HIV disease. J Leukoc Biol. 2011 Sep;90(3):621-8. Epub 2011 Jun 7. PMID: 21653240
  • Weber J, Vazquez AC, Winner D, Rose JD, Wylie D, Rhea AM, Henry K, Pappas J, Wright A, Mohamed N, Gibson R, Rodriguez B, Soriano V, King K, Arts EJ, Olivo PD, Quiñones-Mateu ME. Novel method for simultaneous quantification of phenotypic resistance to maturation, protease, reverse transcriptase, and integrase HIV inhibitors based on 3'Gag(p2/p7/p1/p6)/PR/RT/INT-recombinant viruses: a useful tool in the multitarget era of antiretroviral therapy. Antimicrob Agents Chemother. 2011 Aug;55(8):3729-42. Epub 2011 May 31. PMID: 21628544
  • Vernon LT, Babineau DC, Demko CA, Lederman MM, Wang X, Toossi Z, Weinberg A, Rodriguez B. A prospective cohort study of periodontal disease measures and cardiovascular disease markers in HIV-infected adults. AIDS Res Hum Retroviruses. 2011 Nov;27(11):1157-66. Epub 2011 May 9. PMID: 21443451
  • Yonkers NL, Sieg S, Rodriguez B, Anthony DD. Reduced naive CD4 T cell numbers and impaired induction of CD27 in response to T cell receptor stimulation reflect a state of immune activation in chronic hepatitis C virus infection. J Infect Dis. 2011 Mar 1;203(5):635-45. Epub 2011 Jan 10. PMID: 21220773