Major research programs in the Division of Infectious Diseases & HIV Medicine (ID) focus on basic and translational research in antimicrobial resistance, HIV/AIDS and tuberculosis. The research involves biochemistry, immunology, microbiology and human genetics in the context of epidemiological and observational studies, and clinical trials in these 3 focus areas. The Division has long-standing international research activities in TB and HIV/AIDS with Uganda as primary site. In addition to their individual research programs, ID faculty are involved with or lead major University-wide infectious disease programs including the AIDS Clinical Trials Unit (ACTU), Center for AIDS Research (CFAR), Center for Global Health and Diseases, CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology Studies (Case VA CARES), Geriatric Research Education and Clinical Center (GRECC), Tuberculosis Research Unit (TBRU) and Visual Sciences Research Center (VSRC). Postdoctoral research training in ID is supported by a Training grant from NIH and the GRECC.

The following centers are based in or lead by ID:

AIDS Clinical Trials Unit (ACTU)

ACTUThe Case ACTU (Drs. Lederman and Rodriguez, Co-Directors), supported by NIH and industry, has been in operation since 1987 and is a leader in clinical treatment trials for the management of HIV infection. The ACTU is one of 33 units that comprise the national Adult AIDS Clinical Trials Group (AACTG). Faculty and staff maintain the ACTU, and participate in the design and implementation of new treatment trials for HIV infections and its complications, with an emphasis on trials designed to explore key questions in HIV pathogenesis and the Cure agenda. The ACTU is closely associated with Case’s Center for AIDS Research (CFAR) and its research cores.

Center for Antimicrobial Resistance and Epidemiology Studies (Case VA CARES)

CARESCARES (Dr. Bonomo, Director), supported by NIH, industry, VA and School of Medicine, focuses on the molecular biology and biochemistry of antimicrobial resistance, as well as clinical epidemiology of the spread of antimicrobial resistance and nosocomial infections. CARES bridges research groups based at the VA and School of Medicine.

Geriatric Research Education and Clinical Center (GRECC)

GRECCGRECC (Dr. Bonomo PI; Dr. Canaday Research Director) supported by VA, NIH and industry, focuses on infectious diseases and antibiotic resistance, immunology of aging and treatment of chronic viral infections (HIV, HCV), influenza and varicella zoster virus (VZV) and dementia care.

Tuberculosis Research Unit at CWRU (TBRU)

TBRU (Dr. Boom, Director) supported by NIH, CDC and Bill & Melinda Gates Foundation performs multi-disciplinary research combining epidemiologic studies and clinical trials in TB endemic countries with microbiology, immunology, and human genetics in Uganda and S. Africa. TBRU investigator Dr. Johnson leads Case’s unit of CDC’s TB Trials Consortium (TBTC). TBTC conducts programmatically relevant clinical, laboratory and epidemiologic research concerning the diagnosis, clinical management, and prevention of Mycobacterium tuberculosis infection and disease. Case’s Uganda site is TBTC’s top clinical trial’s site in the world.

Uganda-CWRU Research Collaboration (UCRC)

UCRC (Leadership: Drs. Boom, Johnson, Salata), supported by CDC, NIH and B&MGF, will celebrate its 30th year in 2018 and is the center through which all research in Uganda is organized and administered. UCRC supports 3 labs. (HIV Virology, Immunology, Mycobacteriology) and a clinical studies infrastructure in Uganda for clinical research. The focus has been primarily TB and HIV related research but the scope has been expanded in the last few years to include cardiovascular disease and oncology.

The following centers have ID faculty leadership and participation but are not based in ID:

Center for AIDS Research (CFAR)

Since its foundation in 1994, the Case Western Reserve University Center for AIDS Research (Case CFAR) has been a center of excellence for both clinical and basic AIDS research. CFAR supports basic and translational research in HIV pathogenesis and cure, HIV-TB and HIV-related malignancy. As the first CFAR to make a major investment in international research, CFAR has expanded a highly productive and long-standing scientific relationship with Makerere University, Joint Clinical Research Center (JCRC) and Mulago Hospital, Kampala, Uganda. Participating ID faculty: Drs. Boom, Canaday, Lederman, Salata, Sieg.

Center for Global Health and Diseases

The Center for Global Health was formed in 2002 as a result of a merger between the Center for International Health and the Division of Geographic Medicine. The Center is located in the Biomedical Research Building of Case’s School of Medicine. The Center provides a coordinating structure that links numerous international health resources of the University, its affiliated institutions, and the Northern Ohio community in a multidisciplinary program of research, training and clinical application related to global health. Participating ID faculty: Drs. Boom, Johnson.

Infectious Diseases Clinical Trial’s Unit (IDCTU)

IDCTU (Dr. Salata PI), supported by NIH, is based in the Dept. of Medicine and performs Phase I clinical trials of new antimicrobials. Participating ID faculty: Drs. Fulton, Johnson.

Visual Sciences Research Center (VSRC)

VSCR, supported by NIH, promotes the study of basic and clinical problems of the eye and visual system that may lead to improvements in the prevention and treatment of major blinding disorders worldwide. Through a multidisciplinary research program in vision and ophthalmology involving basic and clinical departments the VSRC seeks to advance the visual sciences at Case. Participating ID faculty: Dr. Subauste.