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Progressive Multifocal Leukoencephalopathy - Case 2

A 29-year-old man with clinical AIDS developed progressive confusion and behavioral changes.

Show the White Matter Lesions

Progressive Multifocal Leukoencephalopathy (PML): Flair axial MRIs. Note the prominent lesion affecting the white matter in the right parietal and occipital areas. Also note the absence of any mass effect. 

PML is a demyelinating disease that results from an opportunistic infection due to the JC virus (named after the initials of the patient in whom it was first discovered), and occurs in AIDS and other immunocompromised patients. It is recognized on imaging studies as a progressive, subacute process affecting the white matter without enhancement or mass effect. There is no known cure. Treatment is supportive and symptomatic.

Revised 11/29/06
Copyrighted 2006. David C Preston