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Primary CNS Lymphoma - Axial Scans

A 72 year-old woman on chronic steroids and immunosuppressants for rheumatoid arthritis developed confusion, poor memory and a left hemiparesis over 3 weeks.

Show the Gadolinium Enhancement                          Show the Vasogenic Edema  

Primary CNS Lymphoma: (Left and Middle) T1-weighted with gadolinium axial MRIs; (Right) T2-weighted axial MRI. Note the large enhancing mass involving the right frontal lobe and the basal ganglia (especially the caudate) with surrounding edema. Biopsy demonstrated lymphoma.

Primary central nervous system lymphoma is a rare brain tumor, primarily seen in immunocompromised patients (e.g., AIDS, organ transplantation). Patients present with headaches, seizures, or focal neurological deficits. The tumor can involve the deep white matter, the meninges, and the eye. If it involves the deep white matter, it may spread across the corpus callosum, similar to the pattern seen in glioblastoma multiforme.


Revised 11/28/06.
Copyrighted 2006. David C Preston