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Glioblastoma - Frontal Lobe - Case 3

A 33 year-old woman presented with a blunted affect and depression.

Outline the Tumor on T2                     Show the Gadolinium Enhancement                    Note the Blood on the GE Image

Glioblastoma Multiforme (Frontal Lobe). (Left) T2-weighted axial MRI; (Middle) T1-weighted with gadolinium axial MRI; (Right) Gradient echo (GE) axial MRI. Note the large enhancing mass in the frontal lobes. This pattern of a frontal tumor crossing over the midline to the contralateral frontal lobe via the corpus callosum is known as a "butterfly" pattern. On the gradient echo image, the dark signal signifies old blood. Biopsy showed glioblastoma multiforme.

Glioblastoma multiforme (GBM), also referred to as a Grade IV astrocytoma, is the most common type of primary brain tumor. It is a malignant tumor that carries a very poor prognosis, and typically results in death in 2 years. On CT and MRI imaging, the tumor is often large, irregular and infiltrative, and located in the white matter with surrounding edema. Histologically, the tumor is highly cellular and anaplastic with necrosis. Associated hemorrhage is not uncommon.

Clinically, patients present with slowly progressive focal neurological signs, and signs of increased intracranial pressure (i.e., headache, nausea, and vomiting). Seizures may be an initial presentation or may occur later in the course.

Revised 11/25/06.
Copyrighted 2006. David C Preston