<% strPathPics = Session("strPathPicsL") imgBg = strPathPics + Session("strMedia") %> pica aneurysm

Posterior Inferior Cerebellar Artery Aneurysm

A 22 year-old man developed the abrupt onset of a severe headache followed by nausea and vomiting.

Outline the Aneurysm

Subarachnoid Hemorrhage - Posterior Inferior Cerebellar Artery Aneurysm. Cerebral angiogram, Left vertebral artery injection, Lateral view. Note the aneurysm arising from the posterior inferior cerebellar artery. This is an uncommon location for a cerebral aneurysm. PICA = posterior inferior cerebellar artery, AICA = anterior inferior cerebellar artery, SCA = superior cerebellar artery, PCA = posterior cerebral artery.

Subarachnoid hemorrhage (SAH) is the extravasation of blood into the subarachnoid space between the pial and arachnoid membranes. The most common causes of spontaneous SAH are rupture of a saccular (berry) aneurysm (80%) and rupture of an arteriovenous malformation (AVM) (10%). Aneurysm formation is also seen in the setting of mycotic aneurysms, as well as in association with some congenital disorders, including coarctation of the aorta, Marfan's syndrome, Ehlers-Danlos syndrome, fibromuscular dysplasia, and polycystic kidney disease. Causes of non-aneurysmal SAH include amyloid angiopathy, blood dyscrasias, fibromuscular dysplasia, Moyamoya disease, and vasculitis (10%).

Aneurysms are usually located in the intracranial arteries which lack an external elastic lamina and have a very thin adventitia. They lie unsupported in the subarachnoid space. The early precursors of aneurysms are small outpouchings through defects in the media of the arteries. These defects expand as a result of hydrostatic pressure from pulsatile blood flow and blood turbulence. The probability of rupture is related to the tension on the aneurysm wall. From the Law of La Place, the tension on the wall is proportional to the diameter. Thus, the rate of rupture is directly related to the size of the aneurysm.. Aneurysms usually occur at arterial bifurcations and mostly arise from the anterior circulation of the Circle of Willis (85%). The most common sites of aneurysms include:

• Posterior communicating artery
• Anterior communicating artery
• Middle cerebral artery bifurcation

Sentinel, or "warning" leaks that produce minor blood leakage are reported to occur in 30-50% of cases. Sentinel bleeds produce sudden focal or generalized head pain that may be severe. They also result in nausea, vomiting, photophobia, malaise, or, less commonly, neck pain. Sentinel bleeds precede aneurysm rupture by a few hours to a few months, with a reported mean of two weeks prior to discovery of the SAH.

Aneurysms can present with a variety of symptoms and signs, the following being the most common:

• A sudden onset of severe headache ("thunderclap headache"), often described as the “worst headache of my life"
• Nuchal pain and rigidity
• A sudden loss of consciousness (occurs in half of patients at bleeding onset; it is usually transient)
• Nausea and/or vomiting
• Photophobia and/or visual disturbances
• Seizures in 10-25% of patients, usually in the first few minutes after bleeding onset
• An expanding aneurysm can present with focal neurological signs from mass effect. The most classic is an ipsilateral 3rd nerve palsy due to an
  expanding posterior communicating artery aneurysm.

Revised 11/30/06.
Copyrighted 2006. David C Preston