Training and educating graduate students in the biomedical sciences is a complex process that continually evolves based on the rapid progression of scientific discovery and ever expanding technological landscape. Graduate programs must continually modify their approaches to meet these modern-day needs. Students are expected to master their overall discipline, become experts in their field of research, as well as gain expertise in a diverse, but interrelated professional skill set. That skill set should be clearly defined, widely communicated and integrated across all PhD disciplines at CWRU SOM. Moreover, a set of common principles or goals for educating all graduate students in the SOM helps to guide our programs in course or curriculum development. The School of Medicine Graduate Education Office, in collaboration with the graduate program directors, developed a formal set of Guiding Principles for the education and training of all Ph.D. students in order to help accomplish these important goals.