Department of Medicine
School of Medicine
Cardiovascular Research Institute
School of Medicine
Center for RNA Science and Therapeutics
School of Medicine
- Metabolism, specifically lipolytic pathways, within the adipose was the focus of my early scientific life. Postdoctoral work at OSU cultivated my interest in the role of visceral adipose inflammation in the etiology and progression of metabolic disease in human disease. An early project hypothesized that anti-inflammatory T-regulatory (Treg) cell populations play an important role, and I set about studying them in the context of the visceral adipose. My findings showed that Treg cells were abundant in normal chow-fed, lean mice as well as in humans with a normal body mass. In high-fat diet feeding in mice, the total and relative number of Treg cells dramatically decreased within the visceral adipose in mice. Similarly, markers for Treg cells in obese humans were lower than in a lean cohort. These findings led to further experimentation concerning the role of co-stimulatory molecules on antigen presenting cells in the adipose. While studying Tregs in human and mouse adipose, I discovered that miR-223 was dramatically upregulated in visceral adipose macrophages from obese insulin resistant patients vs. a lean cohort. I confirmed this in murine, diet-induced and genetic models of obesity and insulin resistance in mice. These findings led to the funding of a K01 by the NIDDK and publications on the topic of microRNAs (a non-protein-coding RNA species) in human and murine obesity and metabolic disease.
- Faculty-related research aims have expanded to study human cardiometabolic disease by examining tissues and fluids from healthy and disease patients using the most up-to-date high throughput techniques (e.g. RNASeq) and bioinformatic approaches to identify pathway abnormalities. Furthermore, the use of isotope-labeled substrates to determine microRNA-mediated changes in innate immune cell metabolism, often called metabolomics, is a method of primary interest. Innate immune cells include monocytes, macrophages, and dendritic cells (myeloid cells), are resident in nearly all human tissues, and are pivotal to potentiating and resolving tissue inflammation.
Awards and Honors
K01 Career Development Awardee - NIH NIDDK
University of Maryland Baltimore and Case Western Reserve University
Assistant Professor, Department of Medicine
University of Maryland Baltimore
Dorothy Davis Heart and Lung Research Institute, OSU Medical Center
For a complete list of publications.
Articles with over 100 citations:
- Deiuliis JA. MicroRNAs as regulators of metabolic disease: pathophysiologic significance and emerging role as biomarkers and therapeutics. Int J Obes. Nature Publishing Group; 2016 Jan;40(1):88–101. PMID: 26311337
- Deiuliis J, Shah Z, Shah N, Needleman B, Mikami D, Narula V, Perry K, Hazey J, Kampfrath T, Kollengode M, Sun Q, Satoskar AR, Lumeng C, Moffatt-Bruce S, Rajagopalan S. Visceral adipose inflammation in obesity is associated with critical alterations in T regulatory cell numbers. PLoS One. 2011;6(1):e16376. PMID: 21298111 PMCID: 3027666.
- Shah Z, Kampfrath T, Deiuliis JA, Zhong J, Pineda C, Ying Z, Xu X, Lu B, Moffatt-Bruce S, Durairaj R, Sun Q, Mihai G, Maiseyeu A, Rajagopalan S. Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis. Circulation. 2011;124(21):2338-49. PMID: 22007077.
- Kampfrath T, Maiseyeu A, Ying Z, Shah Z, Deiuliis JA, Xu X, Kherada N, Brook RD, Reddy KM, Padture NP, Parthasarathy S, Chen LC, Moffatt-Bruce S, Sun Q, Morawietz H, Rajagopalan S. Chronic fine particulate matter exposure induces systemic vascular dysfunction via NADPH oxidase and TLR4 pathways. Circ Res. 2011;108(6):716-26. PMID: 21273555 PMCID: 3085907.
- Shah Z, Pineda C, Kampfrath T, Maiseyeu A, Ying Z, Racoma I, Deiuliis J, Xu X, Sun Q, Moffatt-Bruce S, Villamena F, Rajagopalan S. Acute DPP-4 inhibition modulates vascular tone through GLP-1 independent pathways. Vascular pharmacology. 2011; 55(1-3):2-9. PMID:21397040
- Sun QH, Yue P, Deiuliis JA, Lumeng CN, Kampfrath T, Mikolaj MB, Cai Y, Ostrowski MC, Lu B, Parthasarathy S, Brook RD, Moffatt-Bruce SD, Chen LC, Rajagopalan S. Ambient Air Pollution Exaggerates Adipose Inflammation and Insulin Resistance in a Mouse Model of Diet-Induced Obesity. Circulation. 2009;119(4):538-U91. PMID: 1915326
Book Chapter Published:
- Syed, RM, Deiuliis JA. (2019) Chapter 2: Role of MicroRNAs in Metabolic Diseases. MicroRNAs in Diseases and Disorders: Emerging Therapeutic Targets; Drug Discovery Series. Royal Society of Chemistry Books, London. View Here
Doctor of Philosophy
Nutrition and Molecular Biology
The Ohio State University
Bachelor of Arts
Microbiology and Genetics
Ohio Wesleyan University
Residencies, Internships and Fellowships
Center for Clinical and Translational Science: The Ohio State University
Postdoctoral Researcher, Research Scientist
Davis Heart and Lung Research Institute, The Ohio State University
- 2013-2016: Assistant Professor, Department of Medicine, University of Maryland Baltimore
- 2012-2013: Research Scientist, Dorothy Davis Heart and Lung Research Institute, OSU medical center