Jeffrey Deiuliis, PhD

Assistant Professor
Department of Medicine
School of Medicine
Assistant Professor
Cardiovascular Research Institute
School of Medicine
Assistant Professor
Center for RNA Science and Therapeutics
School of Medicine

Research Information

Research Projects

  1. Metabolism, specifically lipolytic pathways, within the adipose was the focus of my early scientific life.  Postdoctoral work at OSU cultivated my interest in the role of visceral adipose inflammation in the etiology and progression of metabolic disease in human disease. An early project hypothesized that anti-inflammatory T-regulatory (Treg) cell populations play an important role, and I set about studying them in the context of the visceral adipose. My findings showed that Treg cells were abundant in normal chow-fed, lean mice as well as in humans with a normal body mass. In high-fat diet feeding in mice, the total and relative number of Treg cells dramatically decreased within the visceral adipose in mice. Similarly, markers for Treg cells in obese humans were lower than in a lean cohort. These findings led to further experimentation concerning the role of co-stimulatory molecules on antigen presenting cells in the adipose. While studying Tregs in human and mouse adipose, I discovered that miR-223 was dramatically upregulated in visceral adipose macrophages from obese insulin resistant patients vs. a lean cohort. I confirmed this in murine, diet-induced and genetic models of obesity and insulin resistance in mice. These findings led to the funding of a K01 by the NIDDK and publications on the topic of microRNAs (a non-protein-coding RNA species) in human and murine obesity and metabolic disease.
  2. Faculty-related research aims have expanded to study human cardiometabolic disease by examining tissues and fluids from healthy and disease patients using the most up-to-date high throughput techniques (e.g. RNASeq) and bioinformatic approaches to identify pathway abnormalities. Furthermore, the use of isotope-labeled substrates to determine microRNA-mediated changes in innate immune cell metabolism, often called metabolomics, is a method of primary interest. Innate immune cells include monocytes, macrophages, and dendritic cells (myeloid cells), are resident in nearly all human tissues, and are pivotal to potentiating and resolving tissue inflammation.

Awards and Honors

K01 Career Development Awardee - NIH NIDDK
University of Maryland Baltimore and Case Western Reserve University

External Appointments

Assistant Professor, Department of Medicine
University of Maryland Baltimore
2013
2016
Research Scientist
Dorothy Davis Heart and Lung Research Institute, OSU Medical Center
2012
2013

Publications

For a complete list of publications.

Articles with over 100 citations:

Book Chapter Published:

Education

Doctor of Philosophy
Nutrition and Molecular Biology
The Ohio State University
2007
Bachelor of Arts
Microbiology and Genetics
Ohio Wesleyan University
2000

Residencies, Internships and Fellowships

KL2 Fellow
Center for Clinical and Translational Science: The Ohio State University
Postdoctoral Researcher, Research Scientist
Davis Heart and Lung Research Institute, The Ohio State University

Additional Information

  • 2013-2016: Assistant Professor, Department of Medicine, University of Maryland Baltimore
  • 2012-2013: Research Scientist, Dorothy Davis Heart and Lung Research Institute, OSU medical center