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Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma

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The overall objectives of the Case Western Reserve University BETRNet Research Center are:

  1. To conduct a rigorous, integrated spectrum of transdisciplinary human research in Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC);
  2. To increase the biological understanding of key observations made by our clinical researchers;
  3. To translate knowledge derived from genetic, epigenetic and transcriptome research to solving clinical dilemmas in detection, prognosis, prevention and therapy of BE in order to prevent EAC and improve the outcomes of EAC;
  4. To foster a transdisciplinary and translational research culture and to effectively expand and enhance scientific research focused on BE and EAC;
  5. To evaluate research and transdisciplinary programs and to continuously improve research, productivity and enhance translational implementation.

These objectives build and synergize on existing multi-institutional collaborative networks and the considerable clinical, basic science and translational expertise available at our institutions, focusing on improving the outcomes of patients with BE and EAC.

The overarching organizational framework for this Research Center is 1) to focus laboratory research on understanding the genetic susceptibility, genomic and epigenetic changes that influence the development of BE and EAC; and 2) to then translate laboratory discoveries into clinical applications for effective detection, molecular risk stratification, and prevention of progression from BE to EAC.

What is Barrett’s Esophagus?  Learn more on the NIH website.

What is Esophageal Adenocarcinoma?  Find out more on

A picture of the researchers talking in a lab

Our BETRNet Research Center as described on this website is supported by the National Cancer Institute of the National Institutes of Health under Award Number U54CA163060. The content of this website is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.