MSTP Mentors

Biochemistry

Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
Kaixiang Cao, PhD Biochemistry     Elucidating mechanisms underlying stem cell differentiation and mammalian development with genetic, epigenetic, and genomic approaches
J. Alan Diehl, PhD Biochemistry     Discovery of molecular mechanisms that contribute to uncontrolled cell proliferation and decreased cell death. The first area of focus is cell survival and lipid signaling pathways that are utilized during tumorigenesis.  The second area of focus is on the elucidation of mechanisms whereby growth signaling pathways regulate the cell division. 
Thomas Gerken, PhD Biochemistry     Protein structure and dynamics; NMR techniques; molecular modeling of glycoproteins and mucins
Eckhard Jankowsky, PhD Biochemistry Nischay Rege  Sarah Venus, Soon Yi Single-molecule enzymology (RNA helicases) & single molecule studies of ribonucleoprotein machinery (HCV replication and pre-mRNA splicing)
 
Hung-Ying Kao, PhD Biochemistry    

Mechanisms of the transcriptional control by diverse signaling pathways; molecular basis of human diseases related to transcriptional regulation

Focco van den Akker, PhD Biochemistry Nischay Rege   Structural biology; infectious diseases/antibiotic resistance; cardiovascular diseases; small-molecule therapeutics design; cell signaling
 

Biomedical Engineering

Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
A. Bolu Ajiboye, PhD Biomedical Engineering Morgan McGrath Anisha Rastogi Development and control of brain- computer- interface (BCI) technologies for restoring function to individuals who have experienced severely debilitating injuries to the nervous system, such as spinal cord injury and stroke
Jeffrey Capadona, PhD Biomedical Engineering   Sydney Song Developing materials to assimilate within the neural tissue to facilitate molecular level connections with individual neurons 
Dominique Durand, PhD Biomedical Engineering, Neuroscience, Physiology & Biophysics Max Freeberg, Kabilar Gunalan, Bryan Benson, Sydney Song (Tom Ladas, Sheela Toprani, Daniel Levanthal, Bill Stacey) Neural engineering, neural prostheses, magnetic and electric stimulation of the nervous system, electrophysiology of epilepsy, computational neuroscience.
Robert Kirsch, PhD Biomedical Engineering Anisha Rastogi   Mechanics and control of human movement
 
Zheng-Rong Lu, PhD Biomedical Engineering    Peter Qiao Drug delivery and molecular imaging; novel targeted imaging agents for molecular imaging; novel MRI contrast agents; image-guided therapy and drug delivery; polymeric drug delivery systems; multi-functional delivery systems for nucleic acids
Dan Ma, PhD Biomedical Engineering     Fast MR acquisition and reconstruction, MR Fingerprinting,  Quantitative MR imaging, Computational Modeling, Novel MR Imaging Technology for Neurological Diseases. 
Anant Madabhushi, PhD Biomedical Engineering Awuri Asuru,  Jessica Scarborough   Quantitative image analysis; Multi-modal, multi-scale correlation of massive data sets for disease diagnostics, prognostics, theragnostics: cancer applications.
Cameron McIntyre, PhD Biomedical Engineering   Kabilar Gunalan (Tom Foutz, Svjetlana Miocinovic) Deep brain stimulation (DBS) for the treatment of movement disorders and effective application of DBS to new clinical arenas
Andrew Rollins, PhD Biomedical Engineering      Development and application of advanced optics and photonics technologies for imaging and characterization of biological samples, detection of early disease, and monitoring of therapy in human tissues; and investigating embryonic development
Anirban Sen Gupta, PhD Biomedical Engineering, Pathology, Pathology/ Immunology   DaShawn Hickman, Michelle Cruz, Michaela Cooley   Our principal research focus is on mechanistic understanding of biological and pathological phenomena at the cellular, sub-cellular and biomolecular levels in hemostasis, thrombosis, thromboinflammation and cancer, and utilization of this knowledge to create bioinspired therapeutic and diagnostic technologies to interrogate, leverage, or treat these various phenomena
Samuel Senyo, PhD Biomedical Engineering     The Senyo group investigates cellular crosstalk in cardiovascular disease to understand disease progression such as in diabetes and to reverse or repair the injured heart. We model the cellular niche using tissue engineering principles and microfabrication. Dr. Senyo performs comparative studies using mammalian model systems, including human stem cells.
Horst von Recum, PhD Biomedical Engineering Anna Czapar, Anna Henry, Evelyn Ojo   Novel platforms for the delivery of molecules and cells
Satish Viswanath, PhD Biomedical Engineering     Developing medical image analysis and machine learning tools for imaging data, through spatial correlation and cross-linking against pathology or molecular data
David Wilson, PhD Biomedical Engineering Christian Anderson, Charlie Wang, Brian Fort (Roee Lazebnik) Clinical and preclinical detection and characterization of cardiovascular disease, ophthalmological conditions, and cancer using biomedical image analysis and learning systems. Techniques used include segmentation, machine learning, registration, etc., as applied to multiple modalities (e.g., OCT, MRI, CT)
Xin Yu*, ScD Biomedical Engineering Christian Anderson (Didi Goodnough, Charlie Wang)
 * Not currently accepting MSTP students for rotation or PhD placement
 

Cardiovascular Research Institute

Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
Mukesh Jain, MD Physiology & Biophysics, Pathology Anna Henry, Hana Russo, Jennings Luu, Michaela Cooley, Erik Koritzinsky Nelson Hsieh, David Sweet, Liyan Fan Transcriptional mechanisms governing cellular differentiation and function
 
Ganapati Mahabaleshwar, PhD Pathology     Molecular role of novel transcriptional regulators in the pathogenesis of human chronic and acute inflammatory disease conditions

Center for Clinical Investigation

Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
Satya Sahoo, PhD Epidemiology & Biostatistics     (Biomedical Informatics and Brain Connectivity in Neurological Disorders) We study the underlying mechanisms of neurological disorders such as Epilepsy and Movement Disorder (PD) using computational and mathematical models of brain structural and functional networks as they evolve during disease progression.  We are also interested in understanding how clinical events in neurological disorders affect higher order brain functions such as consciousness state and memory. In addition to theoretical models, we have developed Big Data analytic techniques such as Apache Spark libraries to process and analyze large scale data. 
 
James Spilsbury*, PhD, MPH  Epidemiology & Biostatistics, Clinical Translational Science     * Not currently accepting MSTP students for rotation or PhD placement

Center for Global Health & Diseases

Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
James Kazura, MD Pathology/ Immunology Emily Hannon   Immunoregulatory mechanisms of pathogenesis; acquired resistance to infection; malaria
 
Christopher L King, MD, PhD Pathology/ Immunology Gloria Tavera   T cell differentiation, Malaria Schistosomiasis, Filariasis Neonatal immunity, IgE regulation Mechanisms of acquired immunity
 

Center for Proteomics & Bioinformatics

Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
Mark Chance, PhD Genetics, Systems Biology & Bioinformatics, Pathology/  Immunology Dan Jindal Awuri Asuru (Danica Wiredja) Systems Biology, Protein Structure/Function, Cancer, Diabetes
 
John Tilton, MD Molecular Virology     NanoPOD platform for in vivo delivery of protein and RNA therapeutics; HIV-related research using nanoscale flow cytometry to understand viral heterogeneity and its impact on disease; unraveling the mechanisms through which extracellular vesicles fuse with host cells and deliver internal cargos

Center for RNA Molecular Biology

Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
Kristian Baker, PhD Biochemistry, Genetics & Genome Sciences Joel Sax   Mechanisms of nonsense-medated mRNA decay; Mechanisms of mRNA quality control; translation regulation; post transcriptional gene expression
Donny Licatalosi, PhD Biochemistry, Systems Biology & Bioinformatics Susie Suh,    Xinrui Zhang   Understanding how different RBPs regulate gene expression during mouse spermatogenesis, using genetic, bioinformatic, biochemical, and high throughput methods

Chemistry

Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
Blanton Tolbert, PhD Molecular Virology Erin Cohn   Understanding the molecular mechanisms RNA viruses use to express their genomes

Cleveland Clinic Lerner Research Institute

Mentors PhD Programs MSTP Student Rotations MSTP students (and alumni) Research Description
Jay Alberts, PhD Biomedical Engineering  Bryan Benson Morgan McGrath How the brain controls skilled movements, how changes in brain function affect movement performance; Parkinson's disease, stroke, and concussion; improving movement and cognitive performance; concussion and mild dramatic brain injury
Cornelia Bergmann, PhD       Immune responses to viral infections in the central nervous system
Charis Eng, MD, PhD Genetics & Genome Sciences, Pathology/  Molecular and Cellular Basis of Disease, Pathology/ Cancer Biology Ryan Gimple (Emily Nizialek) Cancer genomic medicine translational research; characterization of disease risks in inherited predisposition to cancer; intracytoplasmic trafficking of PTEN and oxidative stress in cancer
Robert Fairchild, PhD Pathology/ Immunology Alex Tong, Claire Mazahery, Otis Pinkard (Tarek El Sawy, Chuck Su, Austin Schenk, Josh Rosenblum, David Yao) T-lymphocyte tolerance, transplantation immunology; T-cell mediated responses in the skin
Emina Huang, MD Pathology/ Cancer Biology    

The development of cancer in the face of chronic inflammation

Stanley Hazen, MD, PhD Cell Biology, Pathology, Systems Biology & Bioinformatics Awuri Asuru Marc Ferrell (Arundhait Undurti, Bob Koeth) Inflammation biology, atherosclerosis, gut floraHDL structure/function, internal medicine, preventive cardiology.
A long term goal of the Hazen laboratory is to understand mechanisms through which inflammation contributes to diseases like atherosclerosis and other chronic degenerative diseases. A major area of interest: the role of intestinal microbiota in the pathogenesis of cardiometabolic diseases, and the pharmacological targeting of metaorganismal pathways in its treatment and prevention. A second research program: the role of nitric oxide and reactive oxidant pathways in inflammatory diseases in vivo, with emphasis on cardiovascular diseases. A final area: HDL structure and function. All research projects rely on multidisciplinary approaches that focus on structural, biochemical, genetic and analytical methods to identify specific reactions/products or pathways, their mechanisms of formation, and involvement in diseases. Research efforts in each program span from bench-to-bedside, including basic/genetic, cellular, animal model, and human clinical investigations
Justin Lathia, PhD

Pathology/ Cancer Biology

  Adam Lauko Our main focus is how stem cell programs drive tumor progression and therapeutic resistance. To achieve this goal, we have active projects in cell adhesion mechanisms, cell-cell communication, and the interaction between tumor cell and the immune system. We also are developing new methods to track the stem cell state in real time and single-cell cell-fate decisions. We work mainly in malignant brain tumors and have leveraged the lessons learned in these tumors to other tumor types including breast and ovarian.
Xiaoxia Li, PhD Pathology/ Immunology Leo Kim, Joseph Rathkey, Susie Suh, Brendan Barton, Muta Abiff, Vanessa Salazar Willie Miller-Little (Brad Martin, Ling Wu) Signal transduction in innate and adaptive immunity
Laura Nagy, PhD Cell Biology, Nutrition, Pathology/ Molecular and Cellular Basis of Disease     Innate immune contributions to alcohol and non-alcoholic induced liver injury, mechanisms of hepatocyte cell death, adipose-gut-liver interactions in alcoholic liver disease, genetic contributions to ALD
Jacob Scott, MD, DPhil Systems Biology & Bioinformatics Eshan King Jessica Scarborough, Davis Weaver * Not currently accepting MSTP students for rotation or PhD placement
Ganes Sen, PhD Biochemistry, Molecular Virology, Pathology/ Immunology Nelson Hsieh (Lenette Lu, Chris Elco) Molecular Virology, Mechanism of Interferon Action, Recombinant DNA Technology, Genetic Regulation of Hypertension
Nima Sharifi, MD Pharmacology     Metabolic and molecular mechanisms of resistance to hormonal therapy in advanced prostate cancer
Jonathan Smith, PhD Pathology     Cell/molecular biology, biochemistry, and genetics/genomics studies of three areas related to cardiovascular disease: atherosclerosis reverse cholesterol transport, and atrial fibrillation
Jennifer Yu, MD, PhD Pathology/ Cancer Biology      Understanding mechanisms underlying key Glioma stem cell (GSC) tumorigenic properties; uncovering potential therapeutic targets

Computer Science and Engineering

Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
Mehmet Koyutürk, PhD Systems Biology & Bioinformatics Danica Wiredja, Stevephen Hung   Bioinformatics and computational biology, network biology, analysis of high-throughput biological data

Family Medicine and Community Health

Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
Kurt Stange, MD, PhD Epidemiology & Biostatistics, Clinical Translational Science   Uriel Kim   The generalist function, primary care practice, practice-based research, cancer prevention and early detection, multi-method research, health promotion, disability prevention, preventive service delivery in primary medical care

General Medical Sciences (Oncology)

Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
Jill Barnholtz-Sloan, PhD Epidemiology & Biostatistics   Peter Liao Cancer genetic/ molecular epidemiology, biostatistics, bioinformatics, systems biology, brain tumors
Seth Field, MD PhD Pathology/Cancer Biology     Cell biology of cancer, including elucidation of fundamental mechanisms of membrane trafficking at atomic and molecular resolution; discovery of signal transduction pathways that regulate the secretory pathway; and their contribution to oncogenic transformation. We have an ongoing program to develop small molecule inhibitors of Golgi vesicle budding to produce leads for novel cancer therapeutics. Many of our findings are also relevant to understanding viral and metabolic diseases.
William Schiemann, PhD Pathology/ Cancer Biology, Pharmacology   Alex Gooding, Nathaniel Robinson The primary goal of our research is to solve the "TGF-β Paradox" and its relationship to the initiation of epithelial-mesenchymal transition, which couples TGF-β to breast cancer metastasis, and to the selection, expansion, and chemoresistance of breast cancer stem cells.

Genetics & Genome Sciences

Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
Drew Adams, PhD Genetics & Genome Sciences, Pharmacology Joel Sax, Yi-Fan Chen, Hannah Kondolf Zita Hubler High-throughput screening and other chemical biology approaches to identify and optimize new drug candidates in neurodegenerative diseases, cancer, and other diseases
Ann Harris, PhD Genetics & Genome Sciences Anniya Gu   Tissue-specific and temporal regulation of gene expression; analysis of cis-regulatory elements and the role of 3D chromatin structure and modifications in regulating transcription; functional genomics of epithelial cells with a focus on cystic fibrosis
Peter Harte, PhD Genetics & Genome Sciences     Epigenetic regulation of chromatin structure and transcription, histone modifying enzymes, Polycomb silencing, genetic control of lifespan and aging
Thomas LaFramboise, PhD Genetics & Genome Sciences, Systems Biology & Bioinformatics Andrea Cohen, Evelyn Ojo, Danica Wiredja, Kathleen Plona, Andrew Morton   Developing and applying computational tools to identify molecular variants, both inherited and somatic, that contribute to cancer and related diseases in humans
Yan Li, PhD Genetics & Genome Sciences Anniya Gu   Single cell genomics and functions of non-coding cis-regulatory elements (such as enhancers) in development and complex diseases, especially related to diabetic conditions 
Hua Lou, PhD Genetics & Genome Sciences     Alternative RNA processing and its role in cancer development
Helen Miranda, PhD Genetics & Genome Sciences     Cell autonomous and non-cell autonomous molecular events involved in spinal bulbar muscular atrophy and amyotrophic lateral sclerosis using induced pluripotent stem cell (iPSC) models
Peter Scacheri, PhD   Genetics & Genome Sciences, Pathology/ Cancer Biology Steve Chirieleison, Stevephen Hung, Ellen Hong Andrew Morton (Andrea Cohen, James Morrow) Investigation of the epigenetic code in human health and disease
Ashleigh Schaffer, PhD Genetics & Genome Sciences Soon Yi, Erin Cohn   Understanding the unique functions of ubiquitously expressed proteins in human brain development and pediatric neurological disease
Paul Tesar, PhD Genetics & Genome Sciences Sarah Taylor, Kevin Allan Matt Ellitt, Kevin Allan (Tyler Miller, Zach Nevin) Stem cell pluripotency and differentiation; developmental neurobiology; developmental genetics
Zhenghe John Wang, PhD Genetics & Genome Sciences, Pathology/Cancer George Luo     Identifying novel genetic alterations, such as somatic mutations, gene amplifications and deletions, which alter critical gene functions involved in development of colon and gastric cancers
Anthony Wynshaw-Boris, MD, PhD Genetics & Genome Sciences Avery Sears, Michael Babinchak, Zita Hubler, Kathleen Plona   Understanding genetic and biochemical pathways important for the development and function of the mammalian central nervous system, using mouse models 

Mechanical & Aerospace Engineering

Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
Umut Gurkan, PhD Biomedical Engineering Will Wulftange   Micro-and nano-scale technologies, biomanufacturing, cell mechanics, and microfluidics

Medicine (Cardiovascular Medicine)

Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
Andrei Maiseyeu, PhD Biomedical Engineering     Our research team develops nanotechnology tools to better understand cardiometabolic diseases such as atherosclerosis, type 2 diabetes, and obesity. We engineer, make, and test new imaging probes, drug delivery vehicles, and sensors that help diagnose and treat these conditions.
Aaron Proweller, MD, PhD Cell Biology Alex Gooding, Colin Stomberski   Molecular pathways regulating vascular development and morphogenesis including the role of Notch signaling in patterning, maturation and contractile function of the arterial vasculature
Diana Ramírez-Bergeron, PhD Genetics & Genome Sciences, Pathology     Anna Henry Borton Adaptive responses to changes in oxygen tension and the effect on blood cells and vessels; influence of hypoxic responses on the generation of cardiovascular stem/progenitor cells and their differentiation into various cardiovascular cell lineages; hypoxia and bone marrow stem cell niches
Jonathan Stamler, MD Biochemistry Steve Chirieleison, Zack Grimmett Colin Stomberski Our focus is on molecular, cellular and physiological aspects of nitric oxide biology, with a major emphasis on the functions of nitric oxide in cellular signaling that are mediated by the ubiquitous post-translational modification of proteins S-nitrosylation, and the role of dysregulated S-nitrosylation in human disease, from heart failure to Alzheimers disease and cancer.

Medicine (Gastroenterology and Hepatology)

Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
Fabio Cominelli, MD, PhD Pathology   Adrian Gomez- Nguyen Crohn's Disease, General GI, Inflammatory Bowel Disease, Ulcerative Colitis

Medicine (Hematology and Oncology)

Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
Afshin Dowlati, MD Biochemistry     Interested in the biology and clinical management of thoracic malignancies, with particular emphasis on translational aspects of drug development. Major focus on small cell lung cancer (SCLC), which comprises ~15% of all lung cancers.
Sanford Markowitz, MD, PhD Molecular Biology & Microbiology, Genetics & Genome Sciences, Pathology/ Cancer Biology Alexandra McMillan, Michal Jandzinski (Josh Friedman, Ryan Fecteau) Colon cancer genetics
Shigemi Matsuyama, DVM, PhD Pharmacology, Pathology/ Cancer Biology Alex Tong    Cancer Cell Biology, Cell Death Regulation, Cell Penetrating Peptide
Reshmi Parameswaran, PhD  Pathology/ Immunology, Cancer Biology   Yorleny Vicioso Novel therapeutic approaches for cancer; activating natural killer cells for adoptive therapy of pediatric cancers; developing therapeutic tools combining immunology with glycobiology; exploiting the cancer cell-specific immune receptors and glycan expression patterns
Stanton Gerson, MD Pathology/ Cancer Biology Kevin Allan  (Lachelle Weeks) Transgenic mice and carcinogenesis, retroviral gene therapy, DNA repair, hematopoietic stem cells

Medicine (Infectious Diseases)

Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
Robert Bonomo, MD Pharmacology, Molecular Biology & Microbiology, Pathology/ Immunology Emma Schroder, Nick Venetos (Jodi Thomson, Sarah Drawz, Marisa Winkler) Structure-function studies of beta-lactamases; enzymological factors that permit evolution of beta-lactamases in the clinic; development of immunological tools to study beta-lactamase expression in enteric bacilli; application of molecular diagnostics to the rapid diagnosis of infectious diseases; testing and development of novel beta-lactams and beta-lactamase inhibitors
W. Henry Boom, MD Pathology/ Immunology, Molecular Biology & Microbiology   (Mursalin Anis, Erika Noss) T cell biology, tuberculosis, immune evasion, pulmonary host defense, antigen processing, anti-microbial immunity, basic and translational TB research
David Canaday, MD Pathology/ Immunology Heather Clark, Gloria Tavera   Immunology of infectious diseases; study of HIV-TB interaction; cellular interactions resulting in loss of control of M. tuberculosis; understanding immune defects that develop with aging
Atul Chopra, MD, PhD Pathology/ Immunology Brendan Boylan, Brian Kim   Energy homeostasis and metabolic disease
Carlos Subauste, MD Pathology/ Immunology     Immunology, autophagy in host-pathogen interactions, Toxoplasma gondii, selective blockade of CD40 signaling to control inflammatory disorders (microvascular complications of diabetes, inflammatory bowel disease).

Molecular Biology & Microbiology

Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
Susann Brady-Kalnay, PhD Molecular Biology & Microbiology, Neurosciences, Cell Biology, Pathology/ Cancer Biology    (Adam Burgoyne, Julia Rosdahl) * Not currently accepting MSTP students for rotation or PhD placement
Jonathan Karn, PhD Molecular Biology & Microbiology     Control of Gene Expression in HIV
Alan Levine, PhD Molecular Biology & Microbiology, Cell Biology, Molecular Virology, Pharmacology, Pathology/Immunology James Ignatz-Hoover, Ryan Stultz Claire Mazahery (Robin Jump, Brenda Rivera-Reyes, Charlotte Chung, Andrew Schade) Role of the microbiome, T lymphocyte, and epithelial cell in intestine immunity
Liem Nguyen, PhD Molecular Biology & Microbiology     Host-mycobacterial interactions; virulence factors of Mycobacterium tuberculosis; antibiotic resistance and cell biology of mycobacteria
Arne Rietsch, PhD Molecular Biology & Microbiology Josie Trichka EmmaM  Schroder Primary virulence factor of P. aeruginosa, a type III secretion system; understanding how this nanomachine works, as well as how the injected effector proteins prevent clearance of the bacterium by the patient’s immune system
Jacek Skowronski, MD, PhD Molecular Biology & Microbiology Abner Murray   Identifying cellular co-factors of HIV/SIV-encoded proteins and selected cellular proteins that can block HIV replication

Neurosciences

Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
Heather Broihier, PhD Neurosciences   Dan Jindal Developmental neurobiology; Molecular mechanisms of synaptic development and plasticity
Evan Deneris, PhD Neurosciences   (Meredith Whitney) Molecular genetics of the brain serotonergic transmitter system
Lin Mei, MD, PhD Neurosciences     Mechanisms of synapse formation, neurotransmission, and synaptic plasticity

 

Pola Philippidou, PhD Neurosciences   Alicia Vagnozzi Molecular mechanisms of neural circuit assembly during development, genetic control of phrenic motor neuron identity; synaptic specificity in respiratory circuits; Hox genes
Jerry Silver, PhD Neurosciences Paul Cheng-Hathaway, Sydney Song, Elliot Choi (Teresa Evans, Michael Fitch) Role of glial cells in development and regeneration of neural circuits, nerve regeneration, glia, axon guidance
Ben Strowbridge, PhD Neurosciences   (Phil Larimer, Robert Hyde, Elisa Chiang, Ramani Balu) Synaptic Physiology, hippocampus, olfactory bulb, Computational Neuroscience
Wen-Cheng Xiong, PhD Neurosciences     Molecular mechanisms underlying neural development, neuro-degeneration, and bone homeostasis
Richard Zigmond, PhD Neurosciences Xinrui Zhang, Willie Miller-Little Aaron Talsma Study of the plasticity in the adult nervous system. We are interested in the ways in which the chemistry of the adult nervous system can change and the functional consequences of such changes. We focus particularly on alterations that occur in response to neural damage whether produced by trauma or disease, with particular interest in neuro-immune interactions that occur in response to injury, using molecular, biochemical, immunological, histochemical, and cell culture approaches

Nutrition

Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
Danny Manor, PhD Nutrition, Pharmacology, Pathology, Cancer Biology Kirkland Wilson   * Not currently accepting MSTP students for rotation or PhD placement

 

Ophthalmology & Visual Sciences

Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
Paul Park, PhD Pharmacology     Mechanism of action of rhodopsin and other G protein-coupled receptors
Irina Pikuleva, PhD Pharmacology Jennings Luu   The two major areas of research in this laboratory are studies of cholesterol maintenance in the retina and brain. The ultimate goal of these studies is to delineate the importance of cholesterol-related pathways for retinal and brain functions and whether pharmacologic modulation of these pathways could lead to disease-modifying treatments for retinal and brain disorders. There is an on-going clinical trial at UH now, which is based on the findings obtained as a result of our research

Orthopedics

Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
Ronald Triolo, PhD Biomedical Engineering Bryan Benson, Peter Liao Max Freeberg Rehabilitation engineering, neural control of motion, lower-extremity neuroprostheses, orthopaedic biomechanics, and prosthetic/orthotic design

Otolaryngology

Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
Brian McDermott, PhD Genetics & Genome Sciences, Neurosciences, Biology Jiayang Li, Kathleen Plona, Jeanette Wat   Sensory Neurobiology, Hearing and Deafness, Zebrafish Genetics, Mechanotransduction, Synapse development, Translational Neuroscience
Qing Zheng, MD Genetics & Genome Sciences     Genes, molecular pathways and drug discovery involved in disease processes in mouse models of human deafness, including Otitis Media (OM) and Usher syndrome

Pathology

 
Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
Derek Abbott, MD, PhD Pathology/ Immunology, Pathology/Cancer Biology Michelle Cruz, Otis Pinkard Bowen Zhou, Joseph Rathkey, Hannah Kondolf (Steven Chirieleison) Inflammatory diseases and innate immune signaling pathways
Stanley Adoro, PhD

Pathology/Cancer Biology, Pathology/ Immunology

 

    Hematopoiesis, hematopoietic stem cells, acute myeloid leukemia, T-cell homeostasis, and autoimmunity
Brian Cobb, PhD Pathology/ Immunology Ling Wu, Heather Clark, Claire Mazahery   Antigen processing and presentation of carbohydrate antigens
Clifford Harding, MD, PhD Pathology/ Immunology Leo Kim, Claire Mazahery, David Sweet (Alyssa Johnsen, Michael Drage, Rose Chu-Beck, Steve Potter, Aaron Tobian, Tom Richardson, Nicole Pecora, Daimon Simmons) Immunology, major histocompatibility complex (MHC) molecules, antigen processing, function of antigen presenting cells and T cells, Toll-like receptors, vaccine adjuvants, Cell Biology, phagocytosis, endocytosis, subcellular fractionation, Infectious Disease, mycobacteria, tuberculosis
Stanley Huang, PhD Pathology/ Immunology Alex Lesser   Understanding the interplay between cellular signaling and metabolic regulation that dictates immune cell activation during inflammation
Mark Jackson, PhD Pathology/ Cancer Biology   (Courtney Bartel) Genetic events that contribute to breast hyperplasia
Qingzhong Kong, PhD Pathology     Prion diseases, functions of cellular prion protein in biology and diseases, muscle stem cells, and gene therapy
Allison Kraus, PhD Pathology/         Molecular and Cellular Basis of Disease     Misfolded proteins and self-propagating protein seeds of neurodegenerative diseases including Alzheimer’s, chronic traumatic encephalopathy, and prion diseases. 
Kenneth Matreyek, PhD Pathology/ Immunology     Understanding how protein sequence variants contribute to disease, and discovering rationally engineered proteins able to fight them. Development and deployment of new multiplex genetic biotechnologies capable of assessing the impacts of protein sequence changes, focusing on genes that modulate immunity or predispose individuals to autoimmunity.
M. Edward Medof, MD, PhD    
 
Pathology     Intrinsic cell surface regulators: the decay-accelerating factor (DAF or CD55), membrane cofactor protein (MCP or CD46), and membrane inhibitor of reactive lysis (MIRL or CD59)
Vincent Monnier, MD Pathology, Biochemistry         Molecular mechanisms of protein aging, oxidative stress, complications of diabetes and aging, cataractogenesis, microbial enzyme technology
Andrew Pieper, MD, PhD Pathology/ Molecular and Cellular Basis of Disease, Neurosciences     Discovery and development of new therapeutic opportunities in neurodegeneration
Parameswaran Ramakrishnan, PhD  Pathology/ Immunology Brendan Barton, Willie Miller-Little    Autoimmune diabetes, chronic inflammation and inflammatory bowel disease, Leukemia, O-GlcNAcylation, Cell signaling and identification of novel therapeutic targets
Jiri Safar, MD Pathology     Prion, Alzheimer, and other neurodegenerative diseases caused by protein misfolding; Prion, amyloid, and tau strains; molecular basis and structural biology of neurodegeneration; translational medicine of age-related dementias.
Thaddeus Stappenbeck, MD, PhD Pathology/ Immunology    

The Stappenbeck lab is interested in discovering host and environmental factors that impact inflammation and wound repair at mucosal surfaces, with the focal point often being the intestinal epithelial barrier.  They use combinations of studies using human cells and tissues as well as mouse and in vitro models to approach these problems.   

Alan Tartakoff, PhD   Pathology Kathleen Plona, Bowen Zhou (Serendipity Rinonos, Jerold Turner) * Not currently accepting MSTP students for rotation or PhD placement
David Wald, MD, PhD Pathology/ Cancer Biology, Pathology/ Immunology Ryan Gimple Evelyn Ojo, (James Ignatz- Hoover) Identification and development of novel therapeutic strategies for cancer with a particular focus on Acute myeloid leukemia (AML) and colon cancer. Preclinical and clinical studies of novel cell therapies for cancer including CAR-T  cells and NK cell therapies
Xinglong Wang, PhD Pathology     Mechanism(s) underlying neuronal death in various major neurodegenerative diseases, with a focus on Alzheimer’s disease, Frontotemporal dementia, and Amyotrophic lateral sclerosis Frontotemporal dementia
T. Sam Xiao, PhD Pathology     Structural and biochemical studies of important immune receptors; understanding and modulating their functions for diagnostic and therapeutic applications
Lan Zhou, MD, PhD Pathology/ Cancer Biology Peter Qiao, Yorleny Vicioso   Notch-dependent regulation of hematopoietic stem cell proliferation, differentiation, and niche location; leukemia microenvironment regulation; Notch signaling in solid tumor progression; fucosylated glycans in hematopoiesis and cancer biology
Xiongwei Zhu, PhD Neuroscience, Pathology Aaron Talsma, Muta Abiff Sirui Jiang Neurodegenerative mechanisms underlying Alzheimer disease and other neurodegenerative diseases

Pediatrics

Mentors PhD Programs MSTP Student Rotations  MSTP Students (and alumni) Research Description
Mitchell Drumm, PhD Genetics & Genome Sciences Kathleen Plona   How variants in the genome influence the course of disease for CF patients and how the CF genome adapts to the disease
Alex Huang, MD, PhD     Pathology/ Cancer Biology, Immunology Ryan Stultz, Derek Wong, Ellen Hong Bryan Benson, Muta Abiff, (Dixon Dorand, Alex Tong) Tumor immunology; Intravital two-photon laser scanning microscopy; T cell and chemokine receptor biology; cellular trafficking, migration and interaction in inflammation, cancer and autoimmunity
John Letterio, MD Biochemistry Brendan Barton George Luo Discovery of the critical roles of TGF-ß in hematopoietic and immune cell function

Pharmacology

Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
Chris Dealwis, PhD Pharmacology     The main focus of my lab involves understanding
the structural organization requirements by multiple protein
assemblies to facilitate biological function, and to rationally
design small molecule inhibitors as drugs against target
molecules responsible for disease states. Our approach is to use a multidisciplinary cycle to study the structure-function
relationship of proteins and drug design. Currently our lab is
designing small molecule drugs against cancer and in the past we have develop therapeutic agents against Alzheimer’s
disease. Biophysical tools such as x-ray; neutron
crystallography, molecular modeling, CD, MS, fluorescence
spectroscopy and ultracentrifugation are the techniques used in our lab. 
Maria Hatzoglou, PhD Nutrition, Pharmacology   Syrena Bracey   Arginine metabolism, gene regulation, viral receptors and gene therapy
Ruth Keri, PhD Pharmacology, Pathology/Cancer Biology Syrena Bracey Bryan Webb, Katrina Piemonte (Jonathan Mosley, Marjorie Montanez-Wiscovich)  Hormonal control of mammary gland development and construction of transgenic mouse models of breast cancer; functional genomics of mammary gland development and cancer
Jason Mears, PhD Pathology, Pharmacology Sirui Jiang     Molecular machinery associated with mitochondrial division in yeast and mammalian cells; understanding the relationship between mitochondrial dynamics and disease
Marvin Nieman, PhD Pharmacology, Cell Biology      Platelet signaling in thrombosis and cancer.
Phoebe Stewart, PhD  Pharmacology     Applying cryo-EM structural methods to a variety of biological complexes including viruses, viral/host factor complexes, engineered adenovirus-based vaccines, membrane proteins and nanoparticles
Derek Taylor, PhD Pharmacology Sirui Jiang, Raza Haider   Computational Biology, Macromolecular Structure Determination, Drug Design. My laboratory defines the molecular mechanisms associated with disease and develops new strategies and therapies for cancer treatment
Edward Yu, PhD Pharmacology     Molecular mechanisms of bacterial efflux transporters that mediate antimicrobial resistance

Physiology & Biophysics

Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
Walter Boron, MD, PhD Biochemistry, Physiology & Biophysics     Regulation of intracellular pH, molecular mechanism and physiological role of bicarbonate transporters and of gas channels
Matthias Buck, PhD Physiology & Biophysics     Molecular Biophysics of small GTPase-protein interactions in neuronal, cardiovascular, and cancer cell signaling; molecular biology, NMR and X-ray spectroscopy, and thermodynamic measurements to determine the basic mechanisms by which proteins transmit signals in cells
Sudha Chakrapani, PhD Physiology & Biophysics, Neurosciences     Role of structure and dynamics in the functioning of ion channels
George Dubyak, PhD Physiology & Biophysics, Pharmacology, Pathology/ Immunology Brian Fort (Hana Russo, Phil Verhoef, Andrew Blum, Michael Katsnelson, Michelle Kahlenberg, Ben Humphreys) Inflammatory and apoptotic signal transduction; Signaling by receptors for extracellular ATP in innate immunity, cardiovascular disease, and cancer
Xin Qi, PhD Physiology & Biophysics Nicholas Venetos, Lucie Ahn   Regulation of mitochondrial dysfunction in neurodegenerative diseases; development of therapeutic approach for the treatment of diseases; cellular and molecular mechanism on mitochondrial quality control and immunometabolism; brain lipid metabolism in neurodegenerative disease
Corey Smith, PhD Physiology & Biophysics     Regulation of the sympatho-adrenal stress response
Julian Stelzer, PhD Physiology & Biophysics   Jiayang Li Cardiac contractility, heart failure, hypertrophic cardiomyopathy, cardiac muscle diseases, cardiac gene therapy, small molecule drug delivery, computational modeling of heart function
Witold Surewicz, PhD Physiology & Biophysics, Pathology   Michael Babinchak, Raza Haider Molecular basis of neurodegenerative diseases associated with protein misfolding and aggregation; The role of liquid-liquid phase separation in neurodegenerative diseases

Population and Quantitative Health Sciences

Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
William Bush, PhD Epidemiology & Biostatistics, Systems Biology & Bioinformatics, Genetics & Genome Sciences     Genomics research on Alzheimer’s disease
Dana Crawford, PhD     Epidemiology & Biostatistics       Applying genetic variation data to large-scale epidemiologic and clinical cohorts to better understand human genotype-phenotype associations, with an emphasis on diverse populations
Darcy Freedman, PhD, MPH Epidemiology & Biostatistics Uriel Kim     Substantive Topic Areas of Interest:  Food Access Interventions (e.g., farmers’ markets, community gardens, food policy); Community-engagement and Civic Participation; Public Health Literacy; Primary Prevention of Chronic Disease (e.g., Obesity, diabetes, cancer); Nutrition and Food Security
Jonathan Haines, PhD Epidemiology & Biostatistics, Genetics & Genome Sciences Zita Hubler, Michael McHenry   Genomic and computational approaches to understand the pathophysiology of human disease
Sudha Iyengar, PhD Epidemiology & Biostatistics, Genetics & Genome Sciences, Systems Biology & Bioinformatics Andrea Cohen, Pam Marcott (Laura Kopplin)  Genetics of complex diseases in humans (ocular genetics/epidemiology, renal genetics, speech sound disorder/epidemiology, genetic methods)
Nora Nock, PhD Epidemiology & Biostatistics, Systems Biology & Bioinformatics     Using various "-omics" and neuroimaging approaches to better understand the genetic, environmental, behavioral and neural determinants of obesity and cancer; innovative lifestyle interventions in overweight and obese cancer survivors
Fredrick Schumacher, PhD Epidemiology & Biostatistics       Deciphering the inherited genetic architecture of complex traits, particularly cancers of the prostate, colon and breast; studies using quantitative and population sciences, particularly molecular and genetic epidemiology, to elucidate the genetic architecture of complex phenotypes
Catherine Stein, PhD Epidemiology & Biostatistics, Systems Biology & Bioinformatics, Clinical and Translational Science   Michael McHenry  Genetic and environmental susceptibility to tuberculosis and other infectious diseases, and multivariate methods for analyzing complex diseases
Daniel Tisch, PhD, MPH Epidemiology & Biostatistics      Epidemiology of lymphatic filariasis, malaria, and schistosomiasis. Meta-analysis and mathematical modeling of parasite control strategies. Evaluation of integrated parasite control programs
Scott Williams, PhD Epidemiology & Biostatistics, Genetics & Genome Sciences   Gloria Tavera  Distribution of genetic variation among human populations and the role that differences in patterns of variation play in disparity of disease among populations; diversity among African and African descent populations; multiple diseases that are either more common in these populations, such as hypertension and preterm birth, or less common, such as gastric cancer
Xiaofeng Zhu, PhD Epidemiology & Biostatistics     Genetic mapping studies of hypertension, obesity; development of statistical methods for association studies avoiding the effect of population stratification; admixture mapping; bioinformatics

Radiology

Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
Agata A Exner, PhD Biomedical Engineering, Pathology/ Cancer Biology Michael Glidden Michaela Cooley (Ravi Patel)  Minimally invasive methods of cancer treatment including: ultrasound-modulated, image-guided drug delivery, thermosensitizers for focused hyperthermia, and vasomodulation for improved local ablation and treatment follow-up
Christopher Flask, PhD Biomedical Engineering   Christian Anderson   Quantitative MRI Assessments of Cystic Fibrosis, Diabetic Nephropathy, Sickle Cell Disease, Pyelonephritis, Polycystic Kidney Disease, and Non-Alcoholic fatty Liver Disease

Rammelkamp Center for Research, MetroHealth Hospital

Mentors PhD Programs MSTP Student Rotations MSTP Students (and alumni) Research Description
Bing-Cheng Wang, PhD Pathology/ Cancer Biology, Pharmacology, Physiology & Biophysics  Courtney Bartel    Molecular mechanisms of tumor initiation and maligant progression of prostate cancer and brain tumor, Tumor immunotherapy, Structure-function relationship of receptort tyrosine kianses, Development of small molecule therapeutics for metastatic cancer