Adam Burgener, PhD

Professor
Department of Pathology
Center for Global Health and Diseases
School of Medicine

Research Information

Research Interests

Our laboratory specializes in mass spectrometry based proteomics and systems biology to study host immunity, the microbiome, and interactions in infectious diseases. A central focus of our research has been to study host and microbial factors at mucosal surfaces that underlie of the acquisition and pathogenesis of HIV. The goal is to apply this knowledge to develop novel preventative, diagnostic, and therapeutic strategies. Our program works in close collaboration and partnership with many domestic and international institutions and clinical cohorts from Africa, United States, Sweden, and Canada.

Website: burgenerlab.com

Publications

For an up to date link to publications from Dr. Burgener please click here

1. Klatt NR, Cheu R, Birse K, Zevin AS, Perner M, Noël-Romas L, Grobler A, Westmacott G, Xie IY, Butler J, Mansoor L, McKinnon LR, Passmore JS, Abdool Karim Q, Abdool Karim SS, Burgener AD. Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women. Science (New York, N.Y.). 2017; 356(6341):938-945. PubMed [journal] PMID: 28572388
 
2. Birse KD, Romas LM, Guthrie BL, Nilsson P, Bosire R, Kiarie J, Farquhar C, Broliden K, Burgener AD. Genital Injury Signatures and Microbiome Alterations Associated With Depot Medroxyprogesterone Acetate Usage and Intravaginal Drying Practices. The Journal of infectious diseases. 2017; 215(4):590-598. PubMed [journal] PMID: 28011908, PMCID: PMC5388302
 
3. Zevin AS, Xie IY, Birse K, Arnold K, Romas L, Westmacott G, Novak RM, McCorrister S, McKinnon LR, Cohen CR, Mackelprang R, Lingappa J, Lauffenburger DA, Klatt NR, Burgener AD. Microbiome Composition and Function Drives Wound-Healing Impairment in the Female Genital Tract. PLoS pathogens. 2016; 12(9):e1005889. PubMed [journal] PMID: 27656899, PMCID: PMC5033340
 
4. Romas L, Birse K, Mayer KH, Abou M, Westmacott G, Giguere R, Febo I, Cranston RD, Carballo-Diéguez A, McGowan I, Burgener A. Rectal 1% Tenofovir Gel Use Associates with Altered Epidermal Protein Expression. AIDS research and human retroviruses. 2016; 32(10-11):1005-1015. PubMed [journal] PMID: 27316778, PMCID: PMC5067863
 
5. Fulcher JA, Romas L, Hoffman JC, Elliott J, Saunders T, Burgener A, Anton PA, Yang OO. Highly HIV-Exposed Seronegative Men Have Lower Mucosal Innate Immune Reactivity. AIDS research and human retroviruses. 2017; PubMed [journal] PMID:
28503933

6. Reeves RK, Burgener A, Klatt NR. Targeting the gastrointestinal tract to develop novel therapies for HIV. Clinical pharmacology and therapeutics. 2015; 98(4):381-6. PubMed [journal] PMID: 26179624

7. Burgener A, McGowan I, Klatt NR. HIV and mucosal barrier interactions: consequences for transmission and pathogenesis. Current opinion in immunology. 2015; 36:22-30. PubMed [journal] PMID: 26151777

8. Arnold KB, Burgener A, Birse K, Romas L, Dunphy LJ, et al. Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins, and an influx of HIV-susceptible target cells. Mucosal immunology. 2015; PubMed [journal] PMID: 26104913

9. Birse KD, Cole AL, Hirbod T, McKinnon L, Ball TB, et al. Non-Cationic Proteins Are Associated with HIV Neutralizing Activity in Genital Secretions of Female Sex Workers. PloS one. 2015; 10(6):e0130404. PubMed [journal] PMID: 26090884, PMCID: PMC4475052

10. Birse K, Arnold KB, Novak RM, McCorrister S, Shaw S, et al. Molecular Signatures of Immune Activation and Epithelial Barrier Remodeling Are Enhanced during the Luteal Phase of the Menstrual Cycle: Implications for HIV Susceptibility. Journal of virology. 2015; 89(17):8793-805. PubMed [journal] PMID: 26085144, PMCID: PMC4524071

11. Hladik F, Burgener A, Ballweber L, Gottardo R, Vojtech L, et al. Correction: Musosal effects for tenofovir 1% gel. eLife. 2015; 4. PubMed [journal] PMID: 25803485, PMCID: PMC4371375

12. Ellegård R, Crisci E, Burgener A, Sjöwall C, Birse K, et al. Complement opsonization of HIV-1 results in decreased antiviral and inflammatory responses in immature dendritic cells via CR3. Journal of immunology (Baltimore, Md. : 1950). 2014; 193(9):4590-601. PubMed [journal] PMID: 25252956, PMCID: PMC4201991

13. Romas LM, Hasselrot K, Aboud LG, Birse KD, Ball TB, et al. A comparative proteomic analysis of the soluble immune factor environment of rectal and oral mucosa. PloS one. 2014; 9(6):e100820. PubMed [journal] PMID: 24978053, PMCID: PMC4076261

14. Aboud L, Ball TB, Tjernlund A, Burgener A. The role of serpin and cystatin antiproteases in mucosal innate immunity and their defense against HIV. American journal of reproductive immunology (New York, N.Y. : 1989). 2014; 71(1):12-23. PubMed [journal] PMID: 24325760

15. Birse KM, Burgener A, Westmacott GR, McCorrister S, Novak RM, et al. Unbiased proteomics analysis demonstrates significant variability in mucosal immune factor expression depending on the site and method of collection. PloS one. 2013; 8(11):e79505. PubMed [journal] PMID: 24244515, PMCID: PMC3828359

16. Tjomsland V, Ellegård R, Burgener A, Mogk K, Che KF, et al. Complement opsonization of HIV-1 results in a different intracellular processing pattern and enhanced MHC class I presentation by dendritic cells. European journal of immunology. 2013; 43(6):1470-83. PubMed [journal] PMID: 23526630, PMCID: PMC3738931

17. Burgener A, Tjernlund A, Kaldensjo T, Abou M, McCorrister S, et al. A systems biology examination of the human female genital tract shows compartmentalization of immune factor expression. Journal of virology. 2013; 87(9):5141-50. PubMed [journal] PMID: 23449785, PMCID: PMC3624310

18. Stein DR, Burgener A, Ball TB. Proteomics as a novel HIV immune monitoring tool. Current opinion in HIV and AIDS. 2013; 8(2):140-6. PubMed [journal] PMID: 23380655

19. Rahman S, Rabbani R, Wachihi C, Kimani J, Plummer FA, et al. Mucosal serpin A1 and A3 levels in HIV highly exposed sero-negative women are affected by the menstrual cycle and hormonal contraceptives but are independent of epidemiological confounders. American journal of reproductive immunology (New York, N.Y. : 1989). 2013; 69(1):64-72. PubMed [journal] PMID: 22971020

Education

Doctor of Philosophy
Microbiology
University of Manitoba
2005