Lindsey Anstine, PhD

Lindsey Anstine

Postdoctoral Researcher

lja32@case.edu

216.368.5924 (o)

I grew up in the rural area outside of Alliance, Ohio and attended Kent State University where I found my passion for molecular biology. My undergraduate research project inspired me to pursue graduate school at The Ohio State University where I obtained my Ph.D in Dr. Joy Lincoln’s lab, studying heart valve disease and development. I joined the Keri lab as a postdoc in order to broaden my training into the cancer field and further develop my expertise in developmental and mechanistic biology.  I enjoy being outdoors and spending time with my family and friends.

Current Research Activities

  • My ongoing postdoctoral research in Dr. Ruth Keri's lab focuses on the identification of novel factors and pathways that can drive the differentiation of highly aggressive basal-like breast cancers. My work has identified a protein that is critical for the maintenance of luminal breast cancer phenotypes. Using a variety of in vitro and in vivo methods, I am currently investigating the mechanism underlying how this protein drives luminal differentiation and represses basal breast cancer phenotypes. This work will be essential for the development of novel therapeutics aimed at improving breast cancer patient survival.

Professional/Volunteer Activities

  • 2007-2011: BS Biology, Honors College, Kent State University
  • 2011-2016: Ph.D. Molecular, Cellular, and Developmental Biology (MCDB) Graduate Program at The Ohio State University. Center for Cardiovascular and Pulmonary Research, The Research Institute at Nationwide Children’s Hospital
  • 2012-2013: MCDB Student Government: Career Day Chair
  • 2013-2014: MCDB Graduate Program Student President
  • 2014-2015: Nationwide Children’s Hospital Graduate Student Research Award Recipient
  • 2014-2016: American Heart Association Predoctoral Fellowship Recipient
  • 2014-2015: NCH Research Institute’s Trainee Association Center Representative 
  • 2015-2016: NCH Research Institute’s Trainee Association Outreach Committee Member
  • 2017-Present: Postdoctoral Scholar, Case Western Reserve University

Awards and Funding

  • 2018: Outstanding Oral Presentation Award; Department of Pharmacology Research Symposium, Case Western Reserve University
  • 2018: Runner-up winning entry in the Art of Science Contest; Case Western Reserve University Graduate Education Office and the School of Medicine
  • 2018-2021: Breast Cancer Breakthrough Fellowship Award; Department of Defense

Publications

  • Alexia Hulin, Lindsey J. Anstine, Andrew J Kim, Sarah J Potter, Tony de Falco, Joy Lincoln and Katherine E. Yutzey. Macrophage transitions in heart valve development and myxomatous valve disease. ATVB. 2018.
  • Lindsey J. Anstine, Tori Horne, Edwin M Horwitz and Joy Lincoln. The contribution of extra-cardiac cells in murine heart valves is age dependent. JAHA. 2017.
  • Lindsey J. Anstine, Chris Bobba, Samir Ghadiali, and Joy Lincoln. Growth and maturation of heart valves leads to decreased endothelial cell distribution, impaired function, metabolism and reduced cell proliferation. JMCC. 2016.
  • Tori E. Horne, Matthew VandeKopple, Kimberly Sauls, Sara N. Koenig, Lindsey J. Anstine, Vidu Garg, Russell A. Norris, and Joy Lincoln.  Dynamic Heterogeneity of the heart valve interstitial cell population in mitral valve health and disease.  JCDD 2015, 2(3), 214-232.
  • Lindsey J. Anstine and Joy Lincoln. Advances in Heart Valve Biomechanics: The Role of Mechanics in Valvular Physiology, Mechanobiology, and the Bioengineering of Repair and Replacement. Molecular and Cellular Developments in Heart Valve Development and Disease. Springer Publication. 2015.
  • Miller, L. J., Lincoln, J. Isolation of Murine Valve Endothelial Cells (2014). J. Vis. Exp. (90), e51860. doi:10.3791/51860
  • Tao, G., Miller, L. J. and Lincoln, J. (2013). Snai1 is important for avian epicardial cell transformation and motility. Dev. Dyn.,242: 699–708. doi: 10.1002/dvdy.23967