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McIntyre Lab



Cameron McIntyre, PhD – Principal Investigator

Cameron McIntyre headshot.Cameron McIntyre, PhD, was born in Marietta, OH in 1974. He received his BS and PhD in Biomedical Engineering from Case Western Reserve University in 1997 and 2001, respectively. His doctoral research focused on the biophysics of the interaction between electric fields and neurons. From 2001 to 2003, he performed postdoctoral training at Johns Hopkins University and Emory University where he studied deep brain stimulation (DBS). In 2003 he joined the faculty at the Cleveland Clinic Foundation and maintained a laboratory there until 2012. In 2013, the McIntyre lab moved to Case Western Reserve University to create the Case Neuromodulation Center.

Cameron is currently appointed as the Tilles-Weidenthal Professor in the School of Medicine Department of Biomedical Engineering. Financial support for the lab has been primarily derived from multiple National Institutes of Health research grants that focus on the neurophysiological effects and engineering design of DBS systems. The fundamental goal of the research program is to use knowledge on the therapeutic mechanisms of DBS to better engineer the next generation of DBS technology. Of particular note, the McIntyre lab invented the GUIDE DBS clinical programming system which was commercialized by the spin-off company IntElect Medical Inc., then acquired by Boston Scientific Neuromodulation Corp and now has CE Mark approval in Europe.

Angela Noecker, BS – Research Associate

Angela Noecker‌Angela is an engineer from Cleveland, OH who writes software and provides support for other members of the McIntyre lab. She graduated from Nebraska Wesleyan University with a BA in Physics, Washington University – St. Louis with a BS in Mechanical Engineering and has 10 years of experience developing medical devices in industry. Her work involves creating software packages that allow patient-specific 3D visualization of MRI and CT brain images, stereotaxic frame data, electrode models, nuclei atlases and neurophysiological microelectrode recording data in a common frame of reference.

Bryan Howell, PhD – Postdoctoral Fellow

Bryan Howell headshotBryan is a postdoctoral fellow originally from San Antonio, Texas, the home of los Spurs. Bryan received his BS degree in biomedical engineering with a Minor in mathematics from The University of Michigan (Ann Arbor, MI) in 2009 and obtained his PhD in biomedical engineering at Duke University (Durham, NC) in 2015. Bryan is currently conducting research on deep brain stimulation for the treatment of refractory depression; his bigger career aspiration is to help develop technologies that scientists and clinicians can use to better treat neurological and psychiatric disorders.

AmirAli Farokhniaee, PhD – Postdoctoral Fellow

AmirAli FarokhniaeeAmirAli is a postdoctoral fellow originally from Tehran, Iran. AmirAli received his BS degree in Atomic-Molecular Physics from University of Tehran in 2009. He graduated from Florida Atlantic University with a MS in Physics and obtained his PhD in Physics at University of Connecticut (Storrs, CT) in 2016. AmirAli is currently doing research on developing network oscillation models within the context of the motor cortex microcircuit. The ultimate goal is to understand the fundamentals and mechanism of neural networks activities under normal, Parkinsonian and deep brain stimulation conditions.

Sinem Balta Beylergil, PhD – Postdoctoral Fellow

Sinem is a postdoctoral fellow originally from Turkey. She graduated from Bogazici University in Istanbul, Turkey, with a BS in Electrical and Electronics Engineering (with a specialization in Control Systems) and a MS in Biomedical Engineering. After a five-year experience as a biomedical engineer in several healthcare companies including GE Healthcare, she decided to pursue a PhD in neuroscience. She obtained her PhD degree in computational neuroscience at the Technical University of Berlin in Germany.  In her PhD dissertation, she used reinforcement learning models and functional magnetic resonance imaging to understand reward-based learning and decision making impairments in alcohol use disorder. Sinem joined our lab in the fall of 2016. Her research focuses on developing a clinical decision support system that uses machine learning and assists clinicians to provide individualized treatment for Parkinson’s patients.

Kelsey Bower, BS – Graduate Student

Kelsey Bower headshotKelsey is a PhD candidate in Biomedical Engineering from Shawnee, PA. She graduated from Johns Hopkins with a BS in Biomedical Engineering. Her research focuses on using fiber tractography and neural activation models to identify white matter pathways responsible for the therapeutic benefits and side effects of DBS. The ultimate goal of her work is to advance our understanding of the neural circuitry involved in STN DBS to improve patient specific DBS targeting.

Anneke Gilbert, MS – Graduate Student

Anneke Frankemölle headshotAnneke is a PhD candidate in Biomedical Engineering from the Netherlands. She graduated from Delft University of Technology with a BS in Mechanical Engineering and an MS in Biomedical Engineering. Her research focuses on optimizing the therapeutic benefits of subthalamic DBS while minimizing DBS-induced side effects in patients with Parkinson’s disease. Her current project will couple fiber tractography with electric field modeling to identify inadvertently stimulated neural pathways resulting in dysarthria.

Kabi Gunalan, PhD – Postdoctoral Fellow

Kabi Gunalan headshotKabi is a postdoctoral fellow from Salt Lake City, UT. He graduated from Johns Hopkins with a BS in Biomedical Engineering and the University of Utah with a MS in Bioengineering. He earned his Ph.D at Case Western Reserve University. His work involves developing software tools to understand how stimulation activates white matter pathways in the brain. The ultimate goal is to enhance our understanding of the specific pathways responsible for therapeutic benefit from DBS.

Suraj Thyagaraj, PhD – Research Associate

Suraj Thyagaraj, PhDSuraj is a research associate from Kerala, India. He graduated from the University of Kerala with a Bachelor's and Southern Illinois University Carbondale with a MS in Mechanical Engineering. He obtained his PhD in Mechanical Engineering from the University of Akron where his dissertation focused on building experimental models for validating phase contrast MRI sequences. His current research focuses on using diffusion weighted imaging and tractography for identifying a biomarker for DBS targeting in type I bipolar disorder (BDI).

Notable Lab Alumni

  • Chris Butson, PhD – University of Utah
  • Michael Moffitt, PhD – Boston Scientific Neuromodulation
  • Matt Johnson, PhD – University of Minnesota
  • Svjetlana Miocinovic, MD, PhD – Emory University
  • Luis Lujan, PhD – Mayo Clinic
  • Ashu Chaturvedi, PhD – Medtronic Neuromodulation
  • Scott Lempka, PhD – University of Michigan
  • Tom Foutz, MD PhD – University of Washington
  • Reuben Shamir, PhD – Surgical Information Sciences
  • Nick Maling, PhD - Boston Scientific